Efficacy and safety of mepolizumab in hypereosinophilic syndrome: A phase III, randomized, placebo-controlled trial

Autor: Amy D. Klion, Florence Roufosse, Marc E. Rothenberg, Suyong Yun Kirby, Jane H Bentley, Jonathan Steinfeld, Martyn J. Gilson, Eric S. Bradford, Steven W. Yancey, Andrew J. Wardlaw, Jean-Emmanuel Kahn, Gerald J. Gleich

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2020, 146 (6), pp.1397-1405. ⟨10.1016/j.jaci.2020.08.037⟩
Journal of allergy and clinical immunology

Background: Anti–IL-5 therapy is a potential treatment for patients with hypereosinophilic syndrome (HES), although its clinical efficacy is unclear. Objective: We sought to investigate the clinical efficacy and safety of mepolizumab versus placebo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918d53754a16796502660c4683784f2a
https://doi.org/10.1016/j.jaci.2020.08.037

Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma

Autor: David A, Stempel, Stanley J, Szefler, Søren, Pedersen, Robert S, Zeiger, Anne M, Yeakey, Laurie A, Lee, Andrew H, Liu, Herman, Mitchell, Kenneth M, Kral, Ibrahim H, Raphiou, Barbara A, Prillaman, Kathleen S, Buaron, Suyong, Yun Kirby, Steven J, Pascoe, John F, Zwetchkenbaum

Publikováno v: Stempel, D A, Szefler, S J, Pedersen, S, Zeiger, R S, Yeakey, A M, Lee, L A, Liu, A H, Mitchell, H, Kral, K M, Raphiou, I H, Prillaman, B A, Buaron, K S, Yun Kirby, S Y K & Pascoe, S J 2016, ' Safety of adding salmeterol to fluticasone propionate in children with asthma ', The New England Journal of Medicine, vol. 375, no. 9, pp. 840-849 . https://doi.org/10.1056/NEJMoa1606356

BACKGROUND Long-acting beta-agonists (LABAs) have been shown to increase the risk of asthmarelated death among adults and the risk of asthma-related hospitalization among children. It is unknown whether the concomitant use of inhaled glucocorticoids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c4fb6f7c12f52b273dda5a58a04dbb
https://doi.org/10.1056/nejmoa1606356

Patient-Reported Symptoms from a Diverse Group of Subjects with Hypereosinophilic Syndrome

Autor: Amy D. Klion, Linda Nelsen, Olga Moshkovich, Jonathan Steinfeld, Suyong Yun Kirby, Paneez Khoury, Nicole Holland-Thomas, Katy Benjamin, Nicholas C. Kovacs

Publikováno v: Journal of Allergy and Clinical Immunology. 137:AB167

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43e871868ad78094d6d2ee7eaf5c8919
https://doi.org/10.1016/j.jaci.2015.12.679

Efficacy and safety of fluticasone furoate nasal spray in adult and adolescent subjects with uncomplicated acute rhinosinusitis

Autor: Paul K. Keith, Andrzej Dymek, Oliver Pfaar, Wytske Fokkens, Nazli Topors, Suyong Yun Kirby, Laurie A. Lee, Wei Wu

Publikováno v: Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Allergy, Asthma & Clinical Immunology, Vol 7, Iss Suppl 2, p A41 (2011)

Methods This randomized, double-blind, placebo-controlled, parallel-group, multicenter, 2-week treatment study evaluated FFNS 110 mcg once daily, twice daily vs. placebo in adults/ adolescents with uncomplicated ARS. Eligibility criteria reflected a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82719f9fb24a3efa92be2153ba34f4a1