Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Suyong Re"'
Autor:
Yosui Nojima, Masahiko Aoki, Suyong Re, Hidekazu Hirano, Yuichi Abe, Ryohei Narumi, Satoshi Muraoka, Hirokazu Shoji, Kazufumi Honda, Takeshi Tomonaga, Kenji Mizuguchi, Narikazu Boku, Jun Adachi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2172-2187 (2023)
Apatinib is known to be a highly selective vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with anti-angiogenic and anti-tumor properties. In a phase III study, the objective response rate to apatinib was low. It remains unclear why
Externí odkaz:
https://doaj.org/article/96f2d6f634004bf692af38e6773e75d9
Autor:
Kento Kasahara, Suyong Re, Grzegorz Nawrocki, Hiraku Oshima, Chiemi Mishima-Tsumagari, Yukako Miyata-Yabuki, Mutsuko Kukimoto-Niino, Isseki Yu, Mikako Shirouzu, Michael Feig, Yuji Sugita
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The intracellular compartment is a crowded environment. Here, the authors use molecular dynamics (MD) simulations to assess inhibitor binding to c-Src kinase and show how ligand binding pathways differ in crowded and dilute protein solutions, highlig
Externí odkaz:
https://doaj.org/article/8d675a4370724533a2e4806e520bcb66
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Molecular dynamics (MD) simulations are increasingly used to study various biological processes such as protein folding, conformational changes, and ligand binding. These processes generally involve slow dynamics that occur on the millisecond or long
Externí odkaz:
https://doaj.org/article/a568190d785a4f1594f242f46e093e2f
Publikováno v:
eLife, Vol 11 (2022)
Spike (S) protein is the primary antigenic target for neutralization and vaccine development for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It decorates the virus surface and undergoes large motions of its receptor binding doma
Externí odkaz:
https://doaj.org/article/e6d2fba80aa44428895594606307f61d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Short, structured fragments of non-coding mRNA may act as molecular switches upon binding specific ligands, regulating the translation of proteins encoded downstream this mRNA sequence. One switch, called riboswitch N1, is regulated by aminoglycoside
Externí odkaz:
https://doaj.org/article/1f39e3f8ac554cfd90f337f7f8b86bf6
Autor:
Suyong Re, Shigehisa Watabe, Wataru Nishima, Eiro Muneyuki, Yoshiki Yamaguchi, Alexander D. MacKerell, Yuji Sugita
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Ion mobility mass spectrometry (IM-MS) is a technique capable of investigating structural changes of biomolecules based on their collision cross section (CCS). Recent advances in IM-MS allow us to separate carbohydrate isomers with subtle co
Externí odkaz:
https://doaj.org/article/a84010791c8642f5ab2dc1e8ef890152
Autor:
Yoshinobu lgarashi1, Suyong Re2, Ryosuke Kojima3, Yasushi Okuno3, Hiroshi Yamada1 h-yamada@nibiohn.go.jp
Publikováno v:
Journal of Toxicological Sciences. 2023, Vol. 48 Issue 5, p243-249. 7p.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 4/9/2024, Vol. 121 Issue 15, p1-9, 27p
Autor:
Taro Tsuji, Kayoko Hashiguchi, Mana Yoshida, Tetsu Ikeda, Yunosuke Koga, Yusaku Honda, Tsukushi Tanaka, Suyong Re, Kenji Mizuguchi, Daisuke Takahashi, Ryo Yazaki, Takashi Ohshima
Publikováno v:
Nature Synthesis. 1:304-312
Considering dynamical aspects of protein-drug binding processes is inevitable in current drug compound design. Conformational plasticity of protein kinases poses a challenge for the design of their inhibitors, and therefore, atomistic molecular dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a253062e21ed3fdf26e1c647ebb7acc
https://doi.org/10.1101/2022.10.25.513784
https://doi.org/10.1101/2022.10.25.513784