Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Suyash Deodhar"'
Autor:
Suyash Deodhar, Brady Sillman, Aditya N. Bade, Sean N. Avedissian, Anthony T. Podany, JoEllyn M. McMillan, Nagsen Gautam, Brandon Hanson, Bhagya L. Dyavar Shetty, Adam Szlachetka, Morgan Johnston, Michellie Thurman, Daniel J. Munt, Alekha K. Dash, Milica Markovic, Arik Dahan, Yazen Alnouti, Alborz Yazdi, Bhavesh D. Kevadiya, Siddappa N. Byrareddy, Samuel M. Cohen, Benson Edagwa, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, using animal models, Deodhar et al. single parenteral dose of dolutegravir (DTG) prodrug nanocrystals sustains drug protein-adjusted 90% inhibitory concentration for up to a year, without injection site reactions or systemic toxicities.
Externí odkaz:
https://doaj.org/article/0e6c6ddce7834d67b915c46f752da67f
Autor:
Denise A. Cobb, Nathan Smith, Suyash Deodhar, Aditya N. Bade, Nagsen Gautam, Bhagya Laxmi Dyavar Shetty, JoEllyn McMillan, Yazen Alnouti, Samuel M. Cohen, Howard E. Gendelman, Benson Edagwa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Antiretroviral therapy (ART) for the treatment of HIV-1 requires life-long daily adherence to supress viral replication, and nucleoside reverse transcriptase inhibitors that are commonly used in ART have not been converted into long-acting agents. He
Externí odkaz:
https://doaj.org/article/e78ef827a6654617b246aed85af2acee
Publikováno v:
BioTech, Vol 12, Iss 2, p 34 (2023)
There have been significant collaborative efforts over the past three years to develop therapies against COVID-19. During this journey, there has also been a lot of focus on understanding at-risk groups of patients who either have pre-existing condit
Externí odkaz:
https://doaj.org/article/8194a01d4fee4fb6a35b72a066eaf8c1
Publikováno v:
BioTech, Vol 11, Iss 1, p 6 (2022)
The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful approval of non-viral nucleic acid therapy products. Despite these developments, nucleic acid t
Externí odkaz:
https://doaj.org/article/1ec080cd44d04264bb03a32e5ed60b71
Autor:
Milica Markovic, Suyash Deodhar, Jatin Machhi, Pravin Yeapuri, Maamoon Saleh, Benson J. Edagwa, Rodney Lee Mosley, Howard E. Gendelman
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 518 (2022)
Prodrugs are bioreversible drug derivatives which are metabolized into a pharmacologically active drug following chemical or enzymatic modification. This approach is designed to overcome several obstacles that are faced by the parent drug in physiolo
Externí odkaz:
https://doaj.org/article/313a5c43035e41a9918848063032bdf1
There have been significant collaborative efforts over the past three years to develop therapies against COVID-19. During this journey, there has also been a lot of focus on understanding at-risk groups of patients who either have pre-existing condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d1053f709ffd1f441a115c1370ba82
Publikováno v:
NeuroImmune Pharmacology and Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5725a67456c7e9c64bdef95b72a3e726
https://doi.org/10.1515/nipt-2023-0001
https://doi.org/10.1515/nipt-2023-0001
Autor:
Aditya N. Bade, Benson J Edagwa, Denise A. Cobb, Samuel M. Cohen, JoEllyn M McMillan, Nathan Smith, Nagsen Gautam, Yazen Alnouti, Suyash Deodhar, Bhagya Laxmi Dyavar Shetty, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Treatment and prevention of human immunodeficiency virus type one (HIV-1) infection was transformed through widespread use of antiretroviral therapy (ART). However, ART has limitations in requiring life-long daily adherence. Such limitations have led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70cf01b79f0883888ebe8b886fef1d0
https://doaj.org/article/e78ef827a6654617b246aed85af2acee
https://doaj.org/article/e78ef827a6654617b246aed85af2acee
The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the successful approval of non-viral gene therapy products in recent times. Despite these developments, gene therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37a26287fd20fc3cdeaa10a8c8ce536
https://doi.org/10.20944/preprints202201.0372.v1
https://doi.org/10.20944/preprints202201.0372.v1
Autor:
Suyash Deodhar, Alekha K. Dash
Publikováno v:
Therapeutic delivery. 9(12)
The poor pharmacokinetic parameters and low solubility of many anticancer therapeutics have warranted the use of drug-delivery systems such as liposomes. Overcoming some drawbacks of the conventional liposomes, targeted liposomal delivery by longer c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a25f3d5862563190a7cae49e759ff5b
https://pubmed.ncbi.nlm.nih.gov/30444455
https://pubmed.ncbi.nlm.nih.gov/30444455