The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

Autor: Pablo Tristán-Ramos, Alejandro Rubio-Roldan, Guillermo Peris, Laura Sánchez, Suyapa Amador-Cubero, Sebastien Viollet, Gael Cristofari, Sara R. Heras

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Human Long INterspersed Element class 1 (LINE-1) elements are expressed and mobilized in many types of cancer, contributing to malignancy. Here the authors show that the tumor suppressor microRNA let-7 targets the LINE-1 mRNA and reduces LINE-1 mobil

Externí odkaz: https://doaj.org/article/92f12109ce524c348a62859af39c4dc9

Engineered LINE-1 retrotransposition in nondividing human neurons

Autor: Jose L. Garcia-Perez, Philip Ng, Alejandro Rubio, Laura Sánchez, Javier García-Castro, Sara R. Heras, John L. Goodier, Angela Macia, Eva Blanco-Jimenez, Martin Muñoz-Lopez, Alysson R. Muotri, Meriem Benkaddour-Boumzaouad, Thomas J. Widmann, Verónica Ayllón, Suyapa Amador-Cubero, Pablo Menendez

Publikováno v: Genome research, vol 27, iss 3
Digibug. Repositorio Institucional de la Universidad de Granada
Consejo Superior de Investigaciones Científicas (CSIC)
Genome Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Macia, A, Widmann, T J, Heras, S R, Ayllon, V, Sanchez, L, Benkaddour-Boumzaouad, M, Muñoz-Lopez, M, Rubio, A, Amador-Cubero, S, Blanco-Jimenez, E, Garcia-Castro, J, Menendez, P, Ng, P, Muotri, A R, Goodier, J L & Garcia-Perez, J L 2017, ' Engineered LINE-1 retrotransposition in nondividing human neurons ', Genome Research, vol. 27, no. 3, pp. 335-348 . https://doi.org/10.1101/gr.206805.116

Half the human genome is made of transposable elements (TEs), whose ongoing activity continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon in the human genome, comprising 17% of its genomic mass and containing an ave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e4a2cc68490e7f36d7c1ef2b3de675
https://doi.org/10.1101/gr.206805.116

Localization of a bacterial group II intron-encoded protein in human cells

Autor: Fernando M. García-Rodríguez, José García Pérez, Mercedes Reinoso-Colacio, Suyapa Amador-Cubero, Marta García-Cañadas, Nicolás Toro

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Reinoso-Colacio, M, García-Rodríguez, F M, García-Cañadas, M, Amador-Cubero, S, García Pérez, J L & Toro, N 2015, ' Localization of a bacterial group II intron-encoded protein in human cells ', Scientific Reports, vol. 5, pp. 12716 . https://doi.org/10.1038/srep12716
Scientific Reports

Group II introns are mobile retroelements that self-splice from precursor RNAs to form ribonucleoparticles (RNP), which can invade new specific genomic DNA sites. This specificity can be reprogrammed, for insertion into any desired DNA site, making t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66252a9a162b53c5d275ee328e6ddc68
http://hdl.handle.net/10261/167449