The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

Autor: Pablo Tristán-Ramos, Alejandro Rubio-Roldan, Guillermo Peris, Laura Sánchez, Suyapa Amador-Cubero, Sebastien Viollet, Gael Cristofari, Sara R. Heras

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Human Long INterspersed Element class 1 (LINE-1) elements are expressed and mobilized in many types of cancer, contributing to malignancy. Here the authors show that the tumor suppressor microRNA let-7 targets the LINE-1 mRNA and reduces LINE-1 mobil

Externí odkaz: https://doaj.org/article/92f12109ce524c348a62859af39c4dc9

Engineered LINE-1 retrotransposition in nondividing human neurons

Autor: Jose L. Garcia-Perez, Philip Ng, Alejandro Rubio, Laura Sánchez, Javier García-Castro, Sara R. Heras, John L. Goodier, Angela Macia, Eva Blanco-Jimenez, Martin Muñoz-Lopez, Alysson R. Muotri, Meriem Benkaddour-Boumzaouad, Thomas J. Widmann, Verónica Ayllón, Suyapa Amador-Cubero, Pablo Menendez

Publikováno v: Genome research, vol 27, iss 3
Digibug. Repositorio Institucional de la Universidad de Granada
Consejo Superior de Investigaciones Científicas (CSIC)
Genome Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Macia, A, Widmann, T J, Heras, S R, Ayllon, V, Sanchez, L, Benkaddour-Boumzaouad, M, Muñoz-Lopez, M, Rubio, A, Amador-Cubero, S, Blanco-Jimenez, E, Garcia-Castro, J, Menendez, P, Ng, P, Muotri, A R, Goodier, J L & Garcia-Perez, J L 2017, ' Engineered LINE-1 retrotransposition in nondividing human neurons ', Genome Research, vol. 27, no. 3, pp. 335-348 . https://doi.org/10.1101/gr.206805.116

Half the human genome is made of transposable elements (TEs), whose ongoing activity continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon in the human genome, comprising 17% of its genomic mass and containing an ave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e4a2cc68490e7f36d7c1ef2b3de675
https://doi.org/10.1101/gr.206805.116

Characterization of Engineered L1 Retrotransposition Events: The Recovery Method

Autor: Andres J Pulgarin, David Cano, Santiago Morell, Suyapa Amador, Jose L. Garcia-Perez

Publikováno v: Methods in Molecular Biology ISBN: 9781493933709
Transposons and Retrotransposons

Long Interspersed Element class 1 retrotransposons (LINE-1 or L1) are abundant Transposable Elements in mammalian genomes and their mobility continues to impact the human genome. The development of engineered retrotransposition assays has been instru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40674dc30e6c16d71c84ee408d1dc419
https://doi.org/10.1007/978-1-4939-3372-3_12

Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2

Autor: Estefanía, Martino-Echarri, Rubén, Fernández-Rodríguez, Francisco Javier, Rodríguez-Baena, Antonio, Barrientos-Durán, Antoni X, Torres-Collado, María del Carmen, Plaza-Calonge, Suyapa, Amador-Cubero, Javier, Cortés, Louise E, Reynolds, Kairbaan M, Hodivala-Dilke, Juan Carlos, Rodríguez-Manzaneque

Publikováno v: International journal of cancer. 133(10)

The extracellular protease ADAMTS1 (A disintegrin and metalloprotease with thrombospondin repeats 1) has been described as an anti-angiogenic molecule and its role as a putative tumor protective molecule has also been suggested. Here, we have used a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9346f1849f49fd25e10a0641e443e28c
https://pubmed.ncbi.nlm.nih.gov/23681936