Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Suxing Jin"'
Autor:
Minglun Liu, Yuncong Chen, Yan Guo, Hao Yuan, Tongxiao Cui, Shankun Yao, Suxing Jin, Huanhuan Fan, Chengjun Wang, Ran Xie, Weijiang He, Zijian Guo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Aggregation induced emission luminogen (AIEgen) based photosensitizers (PSs) have been developed for photodynamic cancer therapy. Here the authors report a series of AIEgen-based PSs that selectively target the Golgi apparatus, showing enhanced singl
Externí odkaz:
https://doaj.org/article/a3bffb64d9ab4b52b901d16c0788e8d8
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 133 (2021)
Platinum-based anticancer drugs represented by cisplatin play important roles in the treatment of various solid tumors. However, their applications are largely compromised by drug resistance and side effects. Much effort has been made to circumvent t
Externí odkaz:
https://doaj.org/article/0f43b455040d47c3b6f3bb729a7e2115
Publikováno v:
Journal of Medicinal Chemistry. 65:520-530
Mitophagy is a selective autophagic process that degrades dysfunctional mitochondria. Monofunctional platinum(II) complexes are candidates for anticancer drugs with the potential to circumvent the drug resistance and side effects of cisplatin and its
Publikováno v:
Chemical science. 13(10)
Alzheimer's disease (AD) is a neurodegenerative illness accompanied by severe memory loss, cognitive disorders and impaired behavioral ability. Amyloid β-peptide (Aβ) aggregation and nucleotide-binding oligomerization domain (NOD)-like receptor pro
Autor:
Yan Guo, Suxing Jin, Dongfan Song, Tao Yang, Jiyong Hu, Xiaowei Hu, Qingqing Han, Jin'an Zhao, Zijian Guo, Xiaoyong Wang
Publikováno v:
European Journal of Medicinal Chemistry. 242:114691
Platinum(IV) prodrugs c,c,t-[PtCl
Autor:
Minglun Liu, Yuncong Chen, Yan Guo, Hao Yuan, Tongxiao Cui, Shankun Yao, Suxing Jin, Huanhuan Fan, Chengjun Wang, Ran Xie, Weijiang He, Zijian Guo
Publikováno v:
Nature communications. 13(1)
Golgi apparatus (GA) oxidative stress induced by in situ reactive oxygen species (ROS) could severely damage the morphology and function of GA, which may open up an avenue for effective photodynamic therapy (PDT). However, due to the lack of effectiv
Autor:
Suxing, Jin, Xiaoyong, Wang
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2276
Platinum-based antitumor drugs play important roles in the clinical treatment of various tumors. Nevertheless, some deficiencies such as poor targeting ability, low bioavailability, in vivo deactivation, drug resistance, and side effects undermine th
Autor:
Xiaoyong Wang, Suxing Jin, Dongfan Song, Zijian Guo, Yan Guo, Zhenzhu Zhu, Tao Yang, Zhenqin Zhang, Yuewen Sun
Publikováno v:
Inorganic Chemistry. 58:6507-6516
Cancer is characterized by abnormal cellular energy metabolism, which preferentially switches to aerobic glycolysis rather than oxidative phosphorylation as a means of glucose metabolism. Many key enzymes involved in the abnormal glycolysis are poten
Alleviation of symptoms of Alzheimer's disease by diminishing Aβ neurotoxicity and neuroinflammation
Autor:
Suxing Jin, Enmao Yin, Yanqing Wang, Zijian Guo, Changli Zhang, Xiaoyong Wang, Hao Yuan, Zhenzhu Zhu, Hongmei Zhang, Tao Yang
Publikováno v:
Chemical Science. 10:10149-10158
Alzheimer's disease (AD) is one of the most prevailing neurodegenerative illnesses in the elderly. Accumulation of amyloid-β peptide (Aβ) and inflammation play critical roles in the pathogenesis and development of AD. Multi-target drugs may interdi
Publikováno v:
Dalton Transactions. 48:3571-3575
A PtIV prodrug bearing a vascular disrupting agent demonstrates antiangiogenic and antimetastatic potentialities against metastatic triple-negative breast cancer cells.