G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits

Autor: Elk Kossatz, Rebeca Diez-Alarcia, Supriya A. Gaitonde, Carla Ramon-Duaso, Tomasz Maciej Stepniewski, David Aranda-Garcia, Itziar Muneta-Arrate, Elodie Tepaz, Suwipa Saen-Oon, Robert Soliva, Aida Shahraki, David Moreira, Jose Brea, Maria Isabel Loza, Rafael de la Torre, Peter Kolb, Michel Bouvier, J. Javier Meana, Patricia Robledo, Jana Selent

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific t

Externí odkaz: https://doaj.org/article/455c7d7ebe814812996e6683dd1c4a42

Δ9‐Tetrahydrocannabinolic acid alleviates collagen‐induced arthritis: Role of PPARγ and CB1receptors

Autor: Giovanni Appendino, Suwipa Saen-oon, María Gómez-Cañas, Eduardo Muñoz, Claudia Gonzalo-Consuegra, Martín Garrido‐Rodriguez, Javier Fernández-Ruiz, Juan A. Collado, Belén Palomares, Robert Soliva, Gaetano Morello, Marco A. Calzado

Publikováno v: British Journal of Pharmacology. 177:4034-4054

Background and purpose Δ9 -Tetrahydrocannabinolic acid (Δ9 -THCA-A), the precursor of Δ9 -THC, is a non-psychotropic phytocannabinoid that shows PPARγ agonist activity. Here, we investigated the ability of Δ9 -THCA-A to modulate the classic cann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cce1807d4c63fbf449a9ec5067bc9f
https://doi.org/10.1111/bph.15155

Δ

Autor: Belén, Palomares, Martín, Garrido-Rodriguez, Claudia, Gonzalo-Consuegra, María, Gómez-Cañas, Suwipa, Saen-Oon, Robert, Soliva, Juan A, Collado, Javier, Fernández-Ruiz, Gaetano, Morello, Marco A, Calzado, Giovanni, Appendino, Eduardo, Muñoz

Publikováno v: Br J Pharmacol

BACKGROUND AND PURPOSE: Δ(9)‐Tetrahydrocannabinolic acid (Δ(9)‐THCA‐A), the precursor of Δ(9)‐THC, is a non‐psychotropic phytocannabinoid that shows PPARγ agonist activity. Here, we investigated the ability of Δ(9)‐THCA‐A to modula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::732b99b7ec994cf9ff374f28ae09351b
https://pubmed.ncbi.nlm.nih.gov/32510591

Computational structure‐based drug design: Predicting target flexibility

Autor: Suwipa Saen-oon, Jelisa Iglesias, Victor Guallar, Robert Soliva

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname

The role of molecular modeling in drug design has experienced a significant revamp in the last decade. The increase in computational resources and molecular models, along with software developments, is finally introducing a competitive advantage in e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad756de845464c4a2844734f6395650
https://hdl.handle.net/2117/117352

A theoretical multiscale treatment of protein-protein electron transfer: the ferredoxin/ferredoxin-NADP+ reductase and flavodoxin/ferredoxin-NADP+ reductase systems

Autor: Milagros Medina, Suwipa Saen-oon, Israel Cabeza de Vaca, Diego Masone, Victor Guallar

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

In the photosynthetic electron transfer (ET) chain, two electrons transfer from photosystem I to the flavin-dependent ferredoxin-NADP+ reductase (FNR) via two sequential independent ferredoxin (Fd) electron carriers. In some algae and cyanobacteria (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc7ee66312d2a7839e1e737265ceaa8
https://hdl.handle.net/2117/84157