Interaction between subventricular zone microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic stroke

Autor: Suvra Nath, Jose C. Martínez Santamaría, Yu-Hsuan Chu, James S. Choi, Pasquale Conforti, Jia-Di Lin, Roman Sankowski, Lukas Amann, Christos Galanis, Kexin Wu, Sachin S. Deshpande, Andreas Vlachos, Marco Prinz, Jae K. Lee, Christian Schachtrup

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract After a stroke, the neurogenic response from the subventricular zone (SVZ) to repair the brain is limited. Microglia, as an integral part of the distinctive SVZ microenvironment, control neural stem / precursor cell (NSPC) behavior. Here, we

Externí odkaz: https://doaj.org/article/7aaae40ae2e04412a7b85444f8236258

Fibrinogen triggered signaling pathways modify stem cell behavior in central nervous system disease

Autor: Jia-Di Lin, Yu-Hsuan Chu, Suvra Nath, Christian Schachtrup

Publikováno v: Neural Regeneration Research, Vol 16, Iss 6, Pp 1196-1197 (2021)

Externí odkaz: https://doaj.org/article/bec63a46c95f46bab006194fa0702087

Fibrinogen regulates lesion border-forming reactive astrocyte properties after vascular damage

Autor: Pasquale Conforti, Szilvia Mezey, Suvra Nath, Yu‐Hsuan Chu, Subash C. Malik, Jose C. Martínez Santamaría, Sachin S. Deshpande, Lauriane Pous, Barbara Zieger, Christian Schachtrup

Publikováno v: GliaREFERENCES. 70(7)

Reactive astrocytes at the border of damaged neuronal tissue organize into a barrier surrounding the fibrotic lesion core, separating this central region of inflammation and fibrosis from healthy tissue. Astrocytes are essential to form the border an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370ef6c5c36a47f1f8c1d7fc0090acbf
https://pubmed.ncbi.nlm.nih.gov/35244976

Synthetic Polymers Provide a Robust Substrate for Functional Neuron Culture

Autor: Mark Bradley, Guy Shpak, Suvra Nath, Yichuan Zhang, Jeffrey Matray, Lidy E. Fratila-Apachitei, Chris I. De Zeeuw, Amir A. Zadpoor, Steven A. Kushner, Seshasailam Venkateswaran, Gustavo A. Higuera

Publikováno v: Advanced Healthcare Materials, 9(4)
Zhang, Y, Venkateswaran, S, Higuera, G A, Nath, S, Shpak, G, Matray, J, Fratila-apachitei, L E, Zadpoor, A A, Kushner, S A, Bradley, M & De Zeeuw, C I 2020, ' Synthetic Polymers Provide a Robust Substrate for Functional Neuron Culture ', Advanced Healthcare Materials, pp. 1901347 . https://doi.org/10.1002/adhm.201901347
Advanced healthcare materials, 9. John Wiley and Sons Ltd
Advanced healthcare materials, 9(4):e1901347. John Wiley & Sons Ltd.

Substrates for neuron culture and implantation are required to be both biocompatible and display surface compositions that support cell attachment, growth, differentiation, and neural activity. Laminin, a naturally occurring extracellular matrix prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2957ea1d5fa09abf359577a2b1c99d
http://resolver.tudelft.nl/uuid:0711096c-c47e-464b-a59a-8282bb306423

Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling

Autor: Verdon Taylor, Sebastian Schildge, Katerina Akassoglou, Francisco Fernández-Klett, Suvra Nath, Christian Bohrer, Könül Topp, Soroush Doostkam, Dietmar Pfeifer, Dennis K. Galanakis, Sachin S. Deshpande, Lauriane Pous, Subash C. Malik, Christian Schachtrup, Szilvia Mezey

Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to brain repair during CNS disease. The microenvironment within the SVZ stem cell niche controls NSPC fate. However, extracellular factors within the niche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991fd4fc927a929332a7ace2c2f60f91
https://pubmed.ncbi.nlm.nih.gov/32005867