Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Suvi T. M. Orr"'
Autor:
Hao Sun, David W Piotrowski, Suvi T M Orr, Joseph S Warmus, Angela C Wolford, Steven B Coffey, Kentaro Futatsugi, Yinsheng Zhang, Alfin D N Vaz
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206279 (2018)
Two chemotypes were examined in vitro with CYPs 3A4 and 2C19 by molecular docking, metabolic profiles, and intrinsic clearance deuterium isotope effects with specifically deuterated form to assess the potential for enhancement of pharmacokinetic para
Externí odkaz:
https://doaj.org/article/5eb59c1e4e2740a591ed41a6ec90eaa8
Autor:
Chengyi Zhang, Sujin Cho-Schultz, Tran Khanh Tuan, Manli Shi, Rose Ann Ferre, Sherry Niessen, Sajiv Krishnan Nair, Douglas Carl Behenna, Dac M. Dinh, Elaine E. Tseng, Theodore O. Johnson, Cheng Hengmiao, Ru Zhou, Michael Zientek, T. Eric Ballard, Brion W. Murray, Suvi T. M. Orr, James Solowiej, Jennifer Lafontaine, Jean Joo Matthews, Scott L. Weinrich, Paolo Vicini, Deal Judith G, Longqing Liu, John Charles Kath, Pairish Mason Alan, Simon Paul Planken, Louise Bernier, Deepak Dalvie, Yiqin Luo, Martin Paul Edwards, Asako Nagata, Hong Shen, Neal W. Sach, Yuli Wang, Ketan S. Gajiwala, Shuibo Xin, Simon Bailey, Chau Almaden, Robert Steven Kania, Michelle Hemkens
Publikováno v:
Journal of Medicinal Chemistry. 60:3002-3019
Mutant epidermal growth factor receptor (EGFR) is a major driver of non-small-cell lung cancer (NSCLC). Marketed first generation inhibitors, such as erlotinib, effect a transient beneficial response in EGFR mutant NSCLC patients before resistance me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b35c90cb7e71bbfee825479df1f470d5
https://doi.org/10.1021/acs.jmedchem.6b01894
https://doi.org/10.1021/acs.jmedchem.6b01894
Autor:
Dilinie P. Fernando, Gary Erik Aspnes, Sophie Y. Lavergne, Daniel W. Kung, Michael Herr, I. D. Pardo, Qifang Li, Norimitsu Shirai, Bryan Goodwin, Suvi T. M. Orr, Jun Zhou, Julie Purkal, Matthew S. Dowling, Kentaro Futatsugi, R. J. Barnes, Declan Flynn, Ahmed M. Shoieb, David Hepworth, T. J. Schmahai, Mark Niosi, W. P. Gorczyca, Kim Huard, John C. Pettersen, Sylvie Perez, Shawn Cabral, James R. Gosset, Theunis C. Goosen
Publikováno v:
MedChemComm. 8:771-779
Small molecule DGAT2 inhibitors have shown promise for the treatment of metabolic diseases in preclinical models. Herein, we report the first toxicological evaluation of imidazopyridine-based DGAT2 inhibitors and show that the arteriopathy associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343a6e4a5a0b00a3db0ba47eb2198e13
https://doi.org/10.1039/c6md00564k
https://doi.org/10.1039/c6md00564k
Autor:
Marlena Walls, Tod Smeal, Suvi T. M. Orr, Zhengyu Liu, Cheng Hengmiao, Shuiwang Wang, Kephart Susan Elizabeth, Jean Joo Matthews, Rose Ann Ferre, Neal W. Sach, Scott L. Weinrich, Doug Behenna, Sherry Niessen, Sangita M. Baxi, Deepak Dalvie, Sujin Cho-Schultz, Dac M. Dinh, Kevin Ryan, Jim Solowiej, Elaine E. Tseng, Simon Paul Planken, Sajiv Krishnan Nair, Brion W. Murray, Jun Li Feng, Jennifer Lafontaine, Pairish Mason Alan, Shijian Ren, Michelle Hemkens, Shuibo Xin, Mehran Jalaie, Tran Khanh Tuan, Robert Steven Kania, Sutton Scott Channing, William F. Vernier, Kevin K.-C. Liu, Amy Jackson-Fisher, Beth Lunney, Min-Jean Yin, Ketan S. Gajiwala, Asako Nagata, Haiwei Xu, Michael Zientek, Ru Zhou, Daniel Tyler Richter, Simon Bailey, Martin Paul Edwards, Martha A. Ornelas, Chau Almaden, John Charles Kath, Hong Shen, Theodore O. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 59:2005-2024
First generation EGFR TKIs (gefitinib, erlotinib) provide significant clinical benefit for NSCLC cancer patients with oncogenic EGFR mutations. Ultimately, these patients’ disease progresses, often driven by a second-site mutation in the EGFR kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd650965ee5ecc3e2b378a7f2542e1b
https://doi.org/10.1021/acs.jmedchem.5b01633
https://doi.org/10.1021/acs.jmedchem.5b01633
Autor:
Steven B. Coffey, Kentaro Futatsugi, Hao Sun, Angela Wolford, Yinsheng Zhang, David W. Piotrowski, Alfin D. N. Vaz, Joseph S. Warmus, Suvi T. M. Orr
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206279 (2018)
PLoS ONE
PLoS ONE
Two chemotypes were examined in vitro with CYPs 3A4 and 2C19 by molecular docking, metabolic profiles, and intrinsic clearance deuterium isotope effects with specifically deuterated form to assess the potential for enhancement of pharmacokinetic para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406e000971086e85e45b7bbdcd248f8f
http://europepmc.org/articles/PMC6235261?pdf=render
http://europepmc.org/articles/PMC6235261?pdf=render
Autor:
Angela Wolford, Heather Eng, Yanwei Zhang, Suvi T. M. Orr, Kay Ahn, Daniel W. Widlicka, Carlin Okerberg, Amit S. Kalgutkar, Yingmei Qi, Samantha N. Spath, Paul D. Bonin, Dilinie P. Fernando, Aaron C. Smith, Tim F. Ryder, Karen Walters, Yan Zhang, David Hepworth, Wenhua Jiao, Joseph S. Warmus, Benjamin N. Rocke, Tristan S. Maurer, Daniel Merritt Bowles, Daniel W. Kung, Scott W. Bagley, Philip A. Carpino, Roger B. Ruggeri, Gang Xing, Leonard Buckbinder, Edward L. Conn, Matthew S. Dowling, Raman Sharma
Publikováno v:
Journal of Medicinal Chemistry. 58:8513-8528
Myeloperoxidase (MPO) is a heme peroxidase that catalyzes the production of hypochlorous acid. Clinical evidence suggests a causal role for MPO in various autoimmune and inflammatory disorders including vasculitis and cardiovascular and Parkinson's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac30d6c8fa4af6183864fd024f9b6af
https://doi.org/10.1021/acs.jmedchem.5b00963
https://doi.org/10.1021/acs.jmedchem.5b00963
Autor:
Anthony Carlo, Matthew S. Dowling, Michael John Munchhof, Robert L. Dow, David Price, Aaron C. Smith, Donna N. Petersen, Athanasia Skoura, Christian Cortes, Allyn T. Londregan, Leonard Buckbinder, Jian Wang, Shenping Liu, Kristen Ford, Samit Kumar Bhattacharya, Paula M. Loria, David Hepworth, Cristiano Ruch Werneck Guimarães, Mark Ammirati, Alan M. Mathiowetz, Wenhua Jiao, Jennifer L. LaPerle, Scott W. Bagley, Ayman El-Kattan, Suvi T. M. Orr, Rebecca Conrad
Publikováno v:
ACS Medicinal Chemistry Letters. 6:1128-1133
Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, a tool compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c7dc48671313aa67336c68fdaefade
https://doi.org/10.1021/acsmedchemlett.5b00215
https://doi.org/10.1021/acsmedchemlett.5b00215
Autor:
Shawn Cabral, Ronald W. Clark, Philip A. Carpino, Csilla C. Jorgensen, Wenhua Jiao, Julie Purkal, Matthew S. Dowling, Suvi T. M. Orr, David Hepworth, Steven B. Coffey, Mark Niosi, Gary Erik Aspnes, Michael Herr, James R. Gosset, Kentaro Futatsugi, Theunis C. Goosen, Derek M. Erion, Bryan Goodwin, Kou Kou, Kay Ahn, Qifang Li, John C. Pettersen, Sylvie Perez, Sophie Y. Lavergne, Brandon Pabst, Daniel W. Kung, Scott Bader, Jeffrey A. Pfefferkorn, Kyuha Lee, Jianwei Bian, Markus Boehm
Publikováno v:
Journal of Medicinal Chemistry. 58:7173-7185
The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described. A screening hit 1 with low lipophilic efficiency (LipE) was optimized through two key structural modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658effc9f945cdc7324e33a364d6f1c4
https://doi.org/10.1021/acs.jmedchem.5b01006
https://doi.org/10.1021/acs.jmedchem.5b01006
Autor:
Colin R. Rose, Dilinie P. Fernando, James Saenz, Kimberly Lapham, Suvi T. M. Orr, Paula M. Loria, Maria von Volkenburg, Beveridge Ramsay, Samit Kumar Bhattacharya, Kimberly O. Cameron, Margaret V. Jackson, Steven B. Coffey, Jun Xiao, Gregory Storer, Vishal Khot, Jigna D. Patel, Ingrid A. Stock, Yingxin Zhang, Kim F. McClure, Derek Vrieze, David Hepworth, Guoqiang Wang, Rachel E. Kosa
Publikováno v:
ACS Medicinal Chemistry Letters. 6:156-161
Several polar heteroaromatic acetic acids and their piperidine amides were synthesized and evaluated as ghrelin or type 1a growth hormone secretagogue receptor (GHS-R1a) inverse agonists. Efforts to improve pharmacokinetic and safety profile was achi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a587643223bea6fb54bae0cbc86036bf
https://doi.org/10.1021/ml500414n
https://doi.org/10.1021/ml500414n
Autor:
Simon, Planken, Douglas C, Behenna, Sajiv K, Nair, Theodore O, Johnson, Asako, Nagata, Chau, Almaden, Simon, Bailey, T Eric, Ballard, Louise, Bernier, Hengmiao, Cheng, Sujin, Cho-Schultz, Deepak, Dalvie, Judith G, Deal, Dac M, Dinh, Martin P, Edwards, Rose Ann, Ferre, Ketan S, Gajiwala, Michelle, Hemkens, Robert S, Kania, John C, Kath, Jean, Matthews, Brion W, Murray, Sherry, Niessen, Suvi T M, Orr, Mason, Pairish, Neal W, Sach, Hong, Shen, Manli, Shi, James, Solowiej, Khanh, Tran, Elaine, Tseng, Paolo, Vicini, Yuli, Wang, Scott L, Weinrich, Ru, Zhou, Michael, Zientek, Longqing, Liu, Yiqin, Luo, Shuibo, Xin, Chengyi, Zhang, Jennifer, Lafontaine
Publikováno v:
Journal of medicinal chemistry. 60(7)
Mutant epidermal growth factor receptor (EGFR) is a major driver of non-small-cell lung cancer (NSCLC). Marketed first generation inhibitors, such as erlotinib, effect a transient beneficial response in EGFR mutant NSCLC patients before resistance me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::424669cfffca599d5b525ea1e0d9fe2e
https://pubmed.ncbi.nlm.nih.gov/28287730
https://pubmed.ncbi.nlm.nih.gov/28287730