Emergence of methicillin resistance predates the clinical use of antibiotics

Autor: Jesper Larsen, Claire L. Raisen, Xiaoliang Ba, Nicholas J. Sadgrove, Guillermo F. Padilla-González, Monique S. J. Simmonds, Igor Loncaric, Heidrun Kerschner, Petra Apfalter, Rainer Hartl, Ariane Deplano, Stien Vandendriessche, Barbora Černá Bolfíková, Pavel Hulva, Maiken C. Arendrup, Rasmus K. Hare, Céline Barnadas, Marc Stegger, Raphael N. Sieber, Robert L. Skov, Andreas Petersen, Øystein Angen, Sophie L. Rasmussen, Carmen Espinosa-Gongora, Frank M. Aarestrup, Laura J. Lindholm, Suvi M. Nykäsenoja, Frederic Laurent, Karsten Becker, Birgit Walther, Corinna Kehrenberg, Christiane Cuny, Franziska Layer, Guido Werner, Wolfgang Witte, Ivonne Stamm, Paolo Moroni, Hannah J. Jørgensen, Hermínia de Lencastre, Emilia Cercenado, Fernando García-Garrote, Stefan Börjesson, Sara Hæggman, Vincent Perreten, Christopher J. Teale, Andrew S. Waller, Bruno Pichon, Martin D. Curran, Matthew J. Ellington, John J. Welch, Sharon J. Peacock, David J. Seilly, Fiona J. E. Morgan, Julian Parkhill, Nazreen F. Hadjirin, Jodi A. Lindsay, Matthew T. G. Holden, Giles F. Edwards, Geoffrey Foster, Gavin K. Paterson, Xavier Didelot, Mark A. Holmes, Ewan M. Harrison, Anders R. Larsen

Publikováno v: Larsen, Jesper; Raisen, Claire L; Ba, Xiaoliang; Sadgrove, Nicholas J; Padilla-González, Guillermo F; Simmonds, Monique S J; Loncaric, Igor; Kerschner, Heidrun; Apfalter, Petra; Hartl, Rainer; Deplano, Ariane; Vandendriessche, Stien; Černá Bolfíková, Barbora; Hulva, Pavel; Arendrup, Maiken C; Hare, Rasmus K; Barnadas, Céline; Stegger, Marc; Sieber, Raphael N; Skov, Robert L; ... (2022). Emergence of methicillin resistance predates the clinical use of antibiotics. Nature, 602(7895), pp. 135-141. Springer Nature Limited 10.1038/s41586-021-04265-w
Larsen, J, Raisen, C L, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Ariane Deplano, A, Vandendriessche, S, Bolfíková, B Č, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L, Nykäsenoja, S, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, J. Teale, C, Waller, A, Pichon, B, Curran, M, Ellington, M, Welch, J, Peacock, S, Seilly, D, Morgan, F, Parkhill, J, Hadjirin, N, Lindsay, J, Holden, M T G, Edwards, G F, Foster, G, Paterson, G, Didelot, X, Holmes, M, Harrison, E & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, no. 7895, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-w
Larsen, J, Raisen, C L, Ba, X, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Deplano, A, Vandendriessche, S, Černá Bolfíková, B, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L J, Nykäsenoja, S M, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H J, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, Teale, C J, Waller, A S, Pichon, B, Curran, M D, Ellington, M J, Welch, J J, Peacock, S J, Seilly, D J, Morgan, F J E, Parkhill, J, Hadjirin, N F, Lindsay, J A, Holden, M T G, Edwards, G F, Foster, G, Paterson, G K, Didelot, X, Holmes, M A, Harrison, E M & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135–141 . https://doi.org/10.1038/s41586-021-04265-w
Paterson, G K 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-w

X.D. was funded by a grant from the National Institute for Health Research (NIHR) Health Protection Research Unit in Genomics and Enabling Data (no. NIHR200892). M.A.H. was supported by grants from the Medical Research Council (nos. G1001787/1, MR/N0

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