Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic HepatitisSummary

Autor: Yuan Li, Joy X. Jiang, Weiguo Fan, Sarah R. Fish, Suvarthi Das, Parul Gupta, Gergely Mozes, Lorand Vancza, Sutapa Sarkar, Koshi Kunimoto, Dongning Chen, Hyesuk Park, Dahn Clemens, Alexey Tomilov, Gino Cortopassi, Natalie J. Török

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 1, Pp 197-211 (2023)

Background & Aims: Src homology and collagen (Shc) proteins are major adapters to extracellular signals, however, the regulatory role of Shc isoforms in sterile inflammatory responses in alcoholic hepatitis (AH) has not been fully investigated. We hy

Externí odkaz: https://doaj.org/article/491df578ef6a4f948fce48a5bdc6e425

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation.

Autor: Firas Alhasson, Suvarthi Das, Ratanesh Seth, Diptadip Dattaroy, Varun Chandrashekaran, Caitlin N Ryan, Luisa S Chan, Traci Testerman, James Burch, Lorne J Hofseth, Ronnie Horner, Mitzi Nagarkatti, Prakash Nagarkatti, Stephen M Lasley, Saurabh Chatterjee

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0172914 (2017)

Many of the symptoms of Gulf War Illness (GWI) that include neurological abnormalities, neuroinflammation, chronic fatigue and gastrointestinal disturbances have been traced to Gulf War chemical exposure. Though the association and subsequent evidenc

Externí odkaz: https://doaj.org/article/7a187cf52903468d946f658d5c67ac39

Nanocarrier vaccines for SARS-CoV-2

Autor: Lalitkumar K. Vora, Dhruvkumar Soni, Milankumar Patel, Srijanee Das, Caroline G. Saksena, Mahmudul Hasan, Farah Shahjin, Ryan F. Donnelly, Maxim D. Oleynikov, Bhavesh D. Kevadiya, Suvarthi Das, Preet Amol Singh, Tapan A Patel, Insiya Mukadam, Mai Mohamed Abdelmoaty, Rajashree Chakraborty, Linda Chang, Jatin Machhi, Neha Bajwa, Ashish Baldi, Raj Kumar, Pravin Yeapuri, Jacob D. Cohen, David Oupicky, Jonathan Herskovitz, Howard E. Gendelman, Kenneth S. Hettie

Publikováno v: Advanced Drug Delivery Reviews
Machhi, J, Shahjin, F, Das, S, Patel, M, Abdelmoaty, M M, Cohen, J D, Singh, P A, Baldi, A, Bajwa, N, Kumar, R, Vora, L K, Patel, T A, Oleynikov, M D, Soni, D, Yeapuri, P, Mukadam, I, Chakraborty, R, Saksena, C G, Herskovitz, J, Hasan, M, Oupicky, D, Das, S, Donnelly, R F, Hettie, K S, Chang, L, Gendelman, H E & Kevadiya, B D 2021, ' Nanocarrier Vaccines for SARS-CoV-2 ', Advanced Drug Delivery Reviews . https://doi.org/10.1016/j.addr.2021.01.002

The SARS-CoV-2 global pandemic has seen rapid spread, disease mobidities and death associated with substantive social, economic and societal impact. Treatments rely on re-purposed antivirals and immune modulatory agents focusing on attenuating the ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64edb5cc527bc03ff3c5b189d5396a6a
https://doi.org/10.1016/j.addr.2021.01.002

Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis

Autor: Yuan Li, Joy X. Jiang, Weiguo Fan, Sarah R. Fish, Suvarthi Das, Parul Gupta, Gergely Mozes, Lorand Vancza, Sutapa Sarkar, Koshi Kunimoto, Dongning Chen, Hyesuk Park, Dahn Clemens, Alexey Tomilov, Gino Cortopassi, Natalie J. Török

Publikováno v: Cellular and molecular gastroenterology and hepatology, vol 15, iss 1

Background & aimsSrc homology and collagen (Shc) proteins are major adapters to extracellular signals, however, the regulatory role of Shc isoforms in sterile inflammatory responses in alcoholic hepatitis (AH) has not been fully investigated. We hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edcffbcbf78e5ea966cf48a91d812a7
https://pubmed.ncbi.nlm.nih.gov/36122677

A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention

Autor: Jonathan Herskovitz, Srijanee Das, Ashish Baldi, Suvarthi Das, Caroline G. Saksena, Jatin Machhi, Tapan A Patel, Mahmudul Hasan, Lalitkumar K. Vora, Preet Amol Singh, Farah Shahjin, David Oupicky, Milankumar Patel, Pravin Yeapuri, Kenneth S. Hettie, Raj Kumar, Jacob D. Cohen, Dhruvkumar Soni, Linda Chang, Maxim D. Oleynikov, Bhavesh D. Kevadiya, Howard E. Gendelman, Neha Bajwa, Ryan F. Donnelly, Insiya Mukadam, Mai Mohamed Abdelmoaty, Rajashree Chakraborty

Publikováno v: Journal of Neuroimmune Pharmacology

Graphical Abstract Extracellular vesicles (EVs) are the common designation for ectosomes, microparticles and microvesicles serving dominant roles in intercellular communication. Both viable and dying cells release EVs to the extracellular environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694b04dae69a233298e41208e94f36f0
https://pubmed.ncbi.nlm.nih.gov/33544324