Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Suvarnamala Pushkaran"'
Autor:
Theodosia A. Kalfa, Suvarnamala Pushkaran, Xiaoling Zhang, James F. Johnson, Dao Pan, Deidre Daria, Hartmut Geiger, Jose A. Cancelas, David A. Williams, Yi Zheng
Publikováno v:
Haematologica, Vol 95, Iss 1 (2010)
Background The small Rho GTPases Rac1 and Rac2 have both overlapping and distinct roles in actin organization, cell survival, and proliferation in various hematopoietic cell lineages. The role of these Rac GTPases in erythropoiesis has not yet been f
Externí odkaz:
https://doaj.org/article/43fee03f0e5944ea9030eabf357a3ef0
Autor:
Alex George, Diamantis G. Konstantinidis, Sebastian Koochaki, Narla Mohandas, Yi Zheng, Suvarnamala Pushkaran, Theodosia A. Kalfa, Punam Malik, Clinton H. Joiner
Publikováno v:
Blood. 121:2099-2107
Chronic inflammation has emerged as an important pathogenic mechanism in sickle cell disease (SCD). One component of this inflammatory response is oxidant stress mediated by reactive oxygen species (ROS) generated by leukocytes, endothelial cells, pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3792dff64b2c8c43a2f60e017326e5
https://doi.org/10.1182/blood-2012-07-441188
https://doi.org/10.1182/blood-2012-07-441188
Autor:
David A. Williams, Xun Shang, Linda Yang, Theodosia A. Kalfa, Yi Zheng, Jose A. Cancelas, Jun Mo, Suvarnamala Pushkaran, Lei Wang
Publikováno v:
Blood. 110:3853-3861
The Rho GTPase Cdc42 regulates adhesion, migration, and homing, as well as cell cycle progression, of hematopoietic stem cells, but its role in multilineage blood development remains unclear. We report here that inducible deletion of cdc42 in cdc42-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c2576c30fda8825f5cc8e852997d27
https://doi.org/10.1182/blood-2007-03-079582
https://doi.org/10.1182/blood-2007-03-079582
Autor:
Theodosia A. Kalfa, Jeffery D. Molkentin, Diedre Daria, Suvarnamala Pushkaran, Andrew G. Koesters, Benjamin T. Spike, Gerald W. Dorn, Kay F. Macleod, Hartmut Geiger, Abhinav Diwan, Bruce J. Aronow, Anil G. Jegga, Amy M. Odley, Christopher P. Baines
Publikováno v:
Proceedings of the National Academy of Sciences. 104:6794-6799
Normal production of RBCs requires that the antiapoptotic protein Bcl-xl be induced at end stages of differentiation in response to erythropoietin (Epo) signaling. The critical proapoptotic pathways inhibited by Bcl-xl in erythroblasts are unknown. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba1dec1c01811094491213decd3a2ac
https://doi.org/10.1073/pnas.0610666104
https://doi.org/10.1073/pnas.0610666104
Autor:
Ursula Klingmüller, Suvarnamala Pushkaran, Mary Risinger, Diamantis G. Konstantinidis, Satwica Yerneni, James Palis, Theodosia A. Kalfa, Ping Zhou, Yi Zheng, Phillip J. Dexheimer, Paul R. Andreassen, Katie M. Giger
Publikováno v:
Blood. 126(12)
RhoA GTPase has been shown in vitro in cell lines and in vivo in nonmammalian organisms to regulate cell division, particularly during cytokinesis and abscission, when 2 daughter cells partition through coordinated actomyosin and microtubule machiner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052ee516c90eb287fd614eb346f99d15
https://pubmed.ncbi.nlm.nih.gov/26228485
https://pubmed.ncbi.nlm.nih.gov/26228485
Autor:
Suvarnamala Pushkaran, Diamantis G. Konstantinidis, Katie M. Giger, Yi Zheng, Stefanos Manganaris, Theodosia A. Kalfa
Erythropoiesis in mammals concludes with the dramatic process of enucleation that results in reticulocyte formation. The mechanism of enucleation has not yet been fully elucidated. A common problem encountered when studying the localization of key pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8f148196e36aad4ce3981863feec03
https://europepmc.org/articles/PMC4186719/
https://europepmc.org/articles/PMC4186719/
Autor:
Benjamin Mizukawa, KarenAnn Kalinyak, James E. Heubi, Alex George, Lana Weckbach, Suvarnamala Pushkaran, Theodosia A. Kalfa
Publikováno v:
Pediatric Blood & Cancer. 56:840-842
We report a novel glucose-6-phosphate dehydrogenase (G6PD) mutation, which we propose to name G6PD Cincinnati (c.1037A>T, p.N346I), found in combination with G6PD Gastonia (c.637G>T, p.V213L) in an infant who presented with neonatal cholestasis. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b709be4ba89391eed2bf6c272964ff
https://doi.org/10.1002/pbc.22744
https://doi.org/10.1002/pbc.22744
Autor:
Jose A. Cancelas, James F. Johnson, Suvarnamala Pushkaran, Stefanos Manganaris, David A. Williams, Theodosia A. Kalfa, Yi Zheng, Chad E. Harris, Diamantis G. Konstantinidis
To understand the role of cytoskeleton and membrane signaling molecules in erythroblast enucleation, we developed a novel analysis protocol of multiparameter high-speed cell imaging in flow. This protocol enabled us to observe F-actin and phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c516081fd0422232f2cbac1e64164cac
https://europepmc.org/articles/PMC3383020/
https://europepmc.org/articles/PMC3383020/
Autor:
Alex George, Narla Mohandas, Clinton H. Joiner, Suvarnamala Pushkaran, Theodosia A. Kalfa, Lina Li, Xiuli An, Yi Zheng
Publikováno v:
Blood cells, moleculesdiseases. 45(1)
The small Rho GTPases Rac1 and Rac2 regulate actin structures and mediate reactive oxygen species (ROS) production via NADPH oxidase in a variety of cells. We have demonstrated that deficiency of Rac1 and Rac2 GTPases in mice disrupts the normal hexa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a05108ca2d43dad80f38bc5d1141e87
https://pubmed.ncbi.nlm.nih.gov/20231105
https://pubmed.ncbi.nlm.nih.gov/20231105
Autor:
Jose A. Cancelas, Deidre Daria, David A. Williams, Yi Zheng, Suvarnamala Pushkaran, Hartmut Geiger, Xiaoling Zhang, Theodosia A. Kalfa, Dao Pan, James F. Johnson
Background The small Rho GTPases Rac1 and Rac2 have both overlapping and distinct roles in actin organization, cell survival, and proliferation in various hematopoietic cell lineages. The role of these Rac GTPases in erythropoiesis has not yet been f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f316e25deabf6164ab2c5be85a1e6a52
https://europepmc.org/articles/PMC2805739/
https://europepmc.org/articles/PMC2805739/