Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sutip, Navankasattusas"'
Autor:
Thirupura S. Shankar, Dinesh K. A. Ramadurai, Kira Steinhorst, Salah Sommakia, Rachit Badolia, Aspasia Thodou Krokidi, Dallen Calder, Sutip Navankasattusas, Paulina Sander, Oh Sung Kwon, Aishwarya Aravamudhan, Jing Ling, Andreas Dendorfer, Changmin Xie, Ohyun Kwon, Emily H. Y. Cheng, Kevin J. Whitehead, Thomas Gudermann, Russel S. Richardson, Frank B. Sachse, Johann Schredelseker, Kenneth W. Spitzer, Dipayan Chaudhuri, Stavros G. Drakos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart f
Externí odkaz:
https://doaj.org/article/5def0b8a41bf407088eed68a7df3942d
Autor:
Yankun Lyu, Vipin K. Verma, Younjee Lee, Iosif Taleb, Rachit Badolia, Thirupura S. Shankar, Christos P. Kyriakopoulos, Craig H. Selzman, William Caine, Rami Alharethi, Sutip Navankasattusas, Thomas Seidel, Stavros G. Drakos, Frank B. Sachse
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract It is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and their differences to chronic heart failure (HF) associated remodeling remain ill-defined. Here,
Externí odkaz:
https://doaj.org/article/59c6d15fd2db497ab916c8eb213cf9df
Autor:
Tomofumi Ando, Ikue Tai-Nagara, Yuki Sugiura, Dai Kusumoto, Koji Okabayashi, Yasuaki Kido, Kohji Sato, Hideyuki Saya, Sutip Navankasattusas, Dean Y. Li, Makoto Suematsu, Yuko Kitagawa, Elena Seiradake, Satoru Yamagishi, Yoshiaki Kubota
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
Blood vessel abnormalization alters cancer cell metabolism and promotes cancer dissemination and metastasis. However, the biological features of the abnormalized blood vessels that facilitate cancer progression and whether they can be targeted therap
Externí odkaz:
https://doaj.org/article/54eb825f41ff4edeab4b2d79fc83af1a
Autor:
Junedh M. Amrute, Lulu Lai, Pan Ma, Andrew L. Koenig, Kenji Kamimoto, Andrea Bredemeyer, Thirupura S. Shankar, Christoph Kuppe, Farid F. Kadyrov, Linda J. Schulte, Dylan Stoutenburg, Benjamin J. Kopecky, Sutip Navankasattusas, Joseph Visker, Samantha A. Morris, Rafael Kramann, Florian Leuschner, Douglas L. Mann, Stavros G. Drakos, Kory J. Lavine
Publikováno v:
Nature Cardiovascular Research. 2:399-416
Autor:
Nikolaos A. Diakos, MD, PhD, Sutip Navankasattusas, PhD, E. Dale Abel, MD, PhD, Jared Rutter, PhD, Lauren McCreath, BS, Peter Ferrin, BS, Stephen H. McKellar, MD, Dylan V. Miller, MD, Song Y. Park, PhD, Russell S. Richardson, PhD, Ralph Deberardinis, MD, James E. Cox, PhD, Abdallah G. Kfoury, MD, Craig H. Selzman, MD, Josef Stehlik, MD, James C. Fang, MD, Dean Y. Li, MD, PhD, Stavros G. Drakos, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 6, Pp 432-444 (2016)
This study sought to investigate the effects of mechanical unloading on myocardial energetics and the metabolic perturbation of heart failure (HF) in an effort to identify potential new therapeutic targets that could enhance the unloading-induced car
Externí odkaz:
https://doaj.org/article/c38480f0b1d54bdf84f5dca61e6ce6da
Autor:
Salah Sommakia, Naredos H. Almaw, Sandra H. Lee, Dinesh K.A. Ramadurai, Iosif Taleb, Christos P. Kyriakopoulos, Chris J. Stubben, Jing Ling, Robert A. Campbell, Rami A. Alharethi, William T. Caine, Sutip Navankasattusas, Guillaume L. Hoareau, Anu E. Abraham, James C. Fang, Craig H. Selzman, Stavros G. Drakos, Dipayan Chaudhuri
Publikováno v:
Circ Heart Fail
Background: Extrinsic control of cardiomyocyte metabolism is poorly understood in heart failure (HF). FGF21 (Fibroblast growth factor 21), a hormonal regulator of metabolism produced mainly in the liver and adipose tissue, is a prime candidate for su
Autor:
Stavros G. Drakos, Rachit Badolia, Aman Makaju, Christos P. Kyriakopoulos, Omar Wever-Pinzon, Christopher M. Tracy, Anna Bakhtina, Ryan Bia, Timothy Parnell, Iosif Taleb, Dinesh K.A. Ramadurai, Sutip Navankasattusas, Elizabeth Dranow, Thomas C. Hanff, Eleni Tseliou, Thirupura S. Shankar, Joseph Visker, Rana Hamouche, Elizabeth L. Stauder, William T. Caine, Rami Alharethi, Craig H. Selzman, Sarah Franklin
Publikováno v:
Circulation.
Background: Extensive evidence from single-center studies indicates that a subset of patients with chronic advanced heart failure (HF) undergoing left ventricular assist device (LVAD) support show significantly improved heart function and reverse str
Autor:
Rachit Badolia, Salah Sommakia, Aishwarya Aravamudhan, Aspasia Thodou Krokidi, Dipayan Chaudhuri, Thomas Gudermann, Paulina Sander, Kira Steinhorst, Ohyun Kwon, Stavros G. Drakos, Dinesh K. A. Ramadurai, Kenneth W. Spitzer, Sutip Navankasattusas, Andreas Dendorfer, Frank B. Sachse, Jing Ling, Emily H. Cheng, Thirupura S. Shankar, Johann Schredelseker, Dallen Calder, Kevin J. Whitehead, Changmin Xie, Oh Sung Kwon, Russel S. Richardson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. Abnormalities in calcium homeostasis often leads to electrical and contractile dysfunction and can
Autor:
Junedh M. Amrute, Lulu Lai, Pan Ma, Andrew L. Koenig, Kenji Kamimoto, Andrea Bredemeyer, Thirupura S. Shankar, Christoph Kuppe, Farid F. Kadyrov, Linda J. Schulte, Dylan Stoutenburg, Benjamin J. Kopecky, Sutip Navankasattusas, Joseph Visker, Samantha A. Morris, Rafael Kramann, Florian Leuschner, Douglas L. Mann, Stavros G. Drakos, Kory J. Lavine
Recovery of cardiac function is the ultimate goal of heart failure therapy. Unfortunately, cardiac recovery remains a rare and poorly understood phemomenon. Herein, we performed single nucleus RNA-sequencing (snRNA-seq) from non-diseased donors and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20df60d0096bfa5ac527c55419ff846f
https://doi.org/10.1101/2022.09.11.507463
https://doi.org/10.1101/2022.09.11.507463
Autor:
Christos P Kyriakopoulos, Joseph R Visker, Ben J Brintz, Iosif Taleb, Rachit Badolia, Benjamin Haaland, Thirupura S Shankar, Jing Ling, Rana Hamouche, Eleni Tseliou, Konstantinos Sideris, Monte Scott, Ethan Krauspe, Sutip Navankasattusas, Omar Wever-Pinzon, Thomas C Hanff, Stephen Bailey, Steven Koenig, Rami Alharethi, Tom H Greene, Craig H Selzman, Mark S Slaughter, Manreet Kanwar, Palak Shah, Stavros G Drakos
Publikováno v:
Journal of Cardiac Failure. 29:547