AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein-specific Th1 response with a diverse TCR repertoire

Autor: Swanson, PA, Padilla, M, Hoyland, W, McGlinchey, K, Fields, PA, Bibi, S, Faust, SN, McDermott, AB, Lambe, T, Pollard, AJ, Durham, NM, Kelly, EJ, AstraZeneca/Oxford/VRC Study Group, Adlou, S, Aley, PK, Angus, B, Anslow, R, Baker, P, Bansal, H, Beveridge, A, Bridges-Webb, A, Ching, S, Cicconi, P, Clutterbuck, EA, Collins, AM, Darton, TC, Demissie, T, Dinesh, T, Douglas, AD, Duncan, CJA, Ewer, KJ, Felle, S, Ferreira, DM, Folegatti, PM, Fuskova, M, Gaudinski, M, Gilbert, SC, Goodman, AL, Gordon, I, Green, CA, Harbolick, E, Hayes, S, Hill, AVS, Hill, H, Jenkin, D, Jepson, BM, Kasanyinga, M, Libri, V, Lillie, PJ, McGregor, AC, Minassian, AM, Mujadidi, YF, Novik, L, Payne, R, Pilataxi, F, Plested, E, Provstgaard-Morys, S, Ramasamy, M, Robinson, H, Sanders, K, Smith, A, Snape, MD, Song, R, Sutherland, RK, Thomson, EC, Toshner, M, Turner, DPJ, Voysey, M, Widge, AT, Williams, CJ

AZD1222 (ChAdOx1 nCoV-19), a replication-deficient simian adenovirus-vectored vaccine, has demonstrated safety, efficacy, and immunogenicity against coronavirus disease 2019 (COVID-19) in clinical trials and real-world studies. We characterized CD4+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::993e6e80c4502ef8c2b6b487068309ee
https://eprints.whiterose.ac.uk/178925/1/scitranslmed.abj7211.pdf

HIV-associated late seminal vesicle ‘BCGosis’ following intravesical bacille Calmette-Guérin therapy.

Autor: Eyre, DW, Mankia, KS, Sutherland, RK, Turner, GD, Conlon, C

Publikováno v: Journal of Clinical Urology; Jan2013, Vol. 6 Issue 1, p20-21, 2p

Comparing Conservative and Early Surgical Treatments for Pyogenic Spondylodiskitis: An International Propensity Score-Matched Retrospective Outcome Analysis.

Autor: Neuhoff J; Center for Spinal Surgery and Neurotraumatology, Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Frankfurt am Main, Germany.; Spondylodiscitis Study Group, EANS Spine Section, Brussels, Belgium., Kramer A; Department of Neurosurgery, University Medical Center Mainz, Mainz, Germany.; Spondylodiscitis Study Group, EANS Spine Section, Brussels, Belgium., Thavarajasingam SG; Department of Neurosurgery, University Medical Center Mainz, Mainz, Germany.; Imperial Brain & Spine Initiative, Imperial College London, London, UK.; Spondylodiscitis Study Group, EANS Spine Section, Brussels, Belgium., Sutherland RK; Department of Infectious Diseases, Western General Hospital, Edinburgh, UK., McCaughan H; Department of Infectious Diseases, Western General Hospital, Edinburgh, UK., Joerger AK; Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany., Wostrack M; Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany., Lyell B; Medical School, University of Edinburgh, Edinburgh, UK., Berkulian O; Center for Spinal Surgery and Neurotraumatology, Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Frankfurt am Main, Germany., Ponniah HS; Medical School, University of Edinburgh, Edinburgh, UK.; Faculty of Medicine, Imperial College London, London, UK.; Imperial Brain & Spine Initiative, Imperial College London, London, UK., Ramsay DSC; Medical School, University of Edinburgh, Edinburgh, UK.; Faculty of Medicine, Imperial College London, London, UK.; Imperial Brain & Spine Initiative, Imperial College London, London, UK., Meyer B; Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany., Kandziora F; Center for Spinal Surgery and Neurotraumatology, Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Frankfurt am Main, Germany., Shiban E; Department of Neurosurgery, Universitätsklinikum Augsburg, Augsburg, Germany.; Spondylodiscitis Study Group, EANS Spine Section, Brussels, Belgium., Davies B; Department of Academic Neurosurgery, Addenbroke's Hospital, Cambridge University Hospital NHS Healthcare Trust, Cambridge, UK.; Spondylodiscitis Study Group, EANS Spine Section, Brussels, Belgium., Demetriades AK; Edinburgh Spinal Surgery Outcome Studies Group, Department of Neurosurgery, Royal Infirmary Edinburgh, NHS Lothian, Edinburgh, UK.; Spondylodiscitis Study Group, EANS Spine Section, Brussels, Belgium., Ringel F; Department of Neurosurgery, University Medical Center Mainz, Mainz, Germany.; Spondylodiscitis Study Group, EANS Spine Section, Brussels, Belgium.

Publikováno v: Neurosurgery [Neurosurgery] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.

Lenacapavir and the novel HIV-1 capsid inhibitors: an emerging therapy in the management of multidrug-resistant HIV-1 virus.

Autor: Lee NE; Clinical Infection Research Group, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, UK., Sutherland RK

Publikováno v: Current opinion in infectious diseases [Curr Opin Infect Dis] 2023 Feb 01; Vol. 36 (1), pp. 15-19.

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.

Autor: Voysey M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Costa Clemens SA; Institute of Global Health, University of Siena, Siena, Italy; Department of Paediatrics, University of Oxford, Oxford, UK., Madhi SA; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa., Weckx LY; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil., Folegatti PM; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Aley PK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Angus B; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Baillie VL; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa., Barnabas SL; Family Centre for Research with Ubuntu, Department of Paediatrics, University of Stellenbosch, Cape Town, South Africa., Bhorat QE; Soweto Clinical Trials Centre, Soweto, South Africa., Bibi S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Briner C; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Cicconi P; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Collins AM; Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Cutland CL; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa., Darton TC; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK; Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Dheda K; Division of Pulmonology, Groote Schuur Hospital and the University of Cape Town, Cape Town, South Africa; Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK., Dold C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Duncan CJA; Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Immunity and Inflammation Theme, Newcastle University, Newcastle upon Tyne, UK., Emary KRW; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Ewer KJ; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Flaxman A; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Fairlie L; Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Feng S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Ferreira DM; Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Finn A; School of Population Health Sciences, University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust, UK., Galiza E; St George's Vaccine Institute, St George's, University of London, London, UK., Goodman AL; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK; MRC Clinical Trials Unit, University College London, London, UK., Green CM; Clinical BioManufacturing Facility, University of Oxford, Oxford, UK., Green CA; NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Greenland M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Hill C; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa., Hill HC; Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Hirsch I; AstraZeneca BioPharmaceuticals, Cambridge, UK., Izu A; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa., Jenkin D; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Joe CCD; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kerridge S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Koen A; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa., Kwatra G; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa., Lazarus R; Severn Pathology, North Bristol NHS Trust, Bristol, UK., Libri V; NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, London, UK., Lillie PJ; Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, UK., Marchevsky NG; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Marshall RP; AstraZeneca BioPharmaceuticals, Cambridge, UK., Mendes AVA; Escola Bahiana de Medicina e Saúde Pública, Salvador, Braziland Hospital São Rafael, Salvador, Brazil; Instituto D'Or, Salvador, Brazil., Milan EP; Universidade Federal do Rio Grande do Norte, Natal, Brazil., Minassian AM; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., McGregor A; London Northwest University Healthcare, Harrow, UK., Mujadidi YF; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Nana A; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Padayachee SD; Setshaba Research Centre, Pretoria, South Africa., Phillips DJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Pittella A; Hospital Quinta D'Or, Rede D'Or, Rio De Janeiro, Brazil., Plested E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Pollock KM; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Ramasamy MN; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Ritchie AJ; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Robinson H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Schwarzbold AV; Clinical Research Unit, Department of Clinical Medicine, Universidade Federal de Santa Maria, Santa Maria, Brazil., Smith A; College of Medical, Veterinary & Life Sciences, Glasgow Dental Hospital & School, University of Glasgow, Glasgow, UK., Song R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Snape MD; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Sprinz E; Infectious Diseases Service, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Sutherland RK; Clinical Infection Research Group, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, UK., Thomson EC; MRC-University of Glasgow Centre for Virus Research & Department of Infectious Diseases, Queen Elizabeth University Hospital, Glasgow, UK., Török ME; Department of Medicine, University of Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Toshner M; Heart Lung Research Institute, Dept of Medicine, University of Cambridge and NIHR Cambridge Clinical Research Facility, Cambridge University Hospital and Royal Papworth NHS Foundation Trusts, Cambridge, UK., Turner DPJ; University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK., Vekemans J; AstraZeneca BioPharmaceuticals, Cambridge, UK., Villafana TL; AstraZeneca BioPharmaceuticals, Cambridge, UK., White T; AstraZeneca BioPharmaceuticals, Cambridge, UK., Williams CJ; Public Health Wales, Cardiff, Wales; Aneurin Bevan University Health Board, Newport, Wales., Douglas AD; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hill AVS; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lambe T; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Gilbert SC; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. Electronic address: andrew.pollard@paediatrics.ox.ac.uk.

Publikováno v: Lancet (London, England) [Lancet] 2021 Mar 06; Vol. 397 (10277), pp. 881-891. Date of Electronic Publication: 2021 Feb 19.