Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Sutherland, JD"'
Autor:
Araújo SJ, Almudi I, Bozal-Basterra L, Casares F, Casas-Tintó S, Escalante A, García-Moreno F, Losada-Pérez M, Maeso I, Marcon L, Ocaña O, Pampliega O, Rada-Iglesias Á, Rayon T, Sharpe J, Sutherland JD, Villa Del Campo C, Barrio R
The Spanish Society for Developmental Biology (SEBD) organized its 17th meeting in November 2020 (herein referred to as SEBD2020). This meeting, originally programmed to take place in the city of Bilbao, was forced onto an online format due to the SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::b31d425f9c32d45289b20d8a37c22484
https://zenodo.org/record/5572847
https://zenodo.org/record/5572847
Autor:
Kırmızıbayrak, Petek Ballar, Gözen, Oğuz, Erzurumlu, Yalçın, Barrio, R, Sutherland, JD, Rodriguez, MS
Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. The mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______9458::9417a90ad155f532ada7c63e64bf5b99
http://hdl.handle.net/11452/30992
http://hdl.handle.net/11452/30992
Since its discovery, the high affinity interaction between biotin and avidin has formed the basis of numerous tools and techniques in molecular biology and biochemistry. The post-translational modifications of cellular proteins via conjugation of ubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4050e8afb443b24898b3f68d21efe084
Autor:
Barrio, R, Sutherland, JD
Publikováno v:
Seminars in celldevelopmental biology.
It is difficult to find a biomedical review article or attend a seminar that does not depict a cellular signaling pathway, schematically drawn out to make sense of the complex interactions that underlie a particular biological process. These cartoons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca52f8c8020ad49da868ee1e8bd6e2c
https://pubmed.ncbi.nlm.nih.gov/31078679
https://pubmed.ncbi.nlm.nih.gov/31078679
Post-translational modifications (PTMs) by ubiquitin (Ub) are versatile, highly dynamic, and involved in nearly all aspects of eukaryote biological function. The reversibility and heterogeneity of Ub chains attached to protein substrates have complic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::5ef3f19be08857fed20f1983b4a04caf
https://zenodo.org/record/2636581
https://zenodo.org/record/2636581
Autor:
Sutherland JD, Barrio R
Defects in protein homeostasis (also known as proteostasis) are intrinsically linked to age-related decline of cardiac function and likely contribute to cardiomyopathies. Protein-folding chaperones and protein quality control systems work overtime in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::aa0a42787dd71a6c5de429ebd60ffac7
https://zenodo.org/record/2636604
https://zenodo.org/record/2636604
Autor:
Bozal-Basterra L, Martín-Ruíz I, Pirone L, Liang Y, Sigurdsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodríguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD, Barrio R
Townes-Brocks syndrome (TBS) is characterized by a spectrum of malformations in the digits, ears, and kidneys. These anomalies overlap those seen in a growing number of ciliopathies, which are genetic syndromes linked to defects in the formation or f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::29d1bbd071e4ac97bb9f14cc0ff209a3
https://zenodo.org/record/2640486
https://zenodo.org/record/2640486
Autor:
Tomás-Cortazar J, Martín-Ruiz I, Barriales D, Pascual-Itoiz MA, Gutierrez de Juan V, Caro-Maldonado A, Merino N, Marina A, Blanco F, Sutherland JD, Barrio R, Rojas A, Martinez-Chantar ML, Carracedo A, Simó C, García-Cañas V, Abecia L, Lavín JL, Aransay AM, Rodríguez H, Anguita J
Salp15, a salivary protein of Ixodes ticks, inhibits the activation of naïve CD4 T cells. Treatment with Salp15 results in the inhibition of early signaling events and the production of the autocrine growth factor, interleukin-2. The fate of the CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::df05f208ea7eb923a12bcc65637d87cc
https://zenodo.org/record/2640517
https://zenodo.org/record/2640517
Autor:
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs that sustain cancer cell growth and proliferation1,2. Here we show that mTORC1 regulates polyamine dynamics, a metabolic route that is essential for oncogenicity. Through the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::824535b8c51e40827ce59dc4e0b74b8d
https://zenodo.org/record/2640538
https://zenodo.org/record/2640538
Autor:
Martinez A, Lectez B, Ramirez J, Popp O, Sutherland JD, Urbé S, Dittmar G, Clague MJ, Mayor U.
Background: Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson’s Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates Parkin activity leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::ffc1201ea213dda98cff913b5d4c1611
https://zenodo.org/record/2640545
https://zenodo.org/record/2640545