Zobrazeno 1 - 10
of 426
pro vyhledávání: '"Suthat, Fucharoen"'
Autor:
Poochit Nonejuie, Alisa Wilantho, Daniel McDonald, Htut Htut Htoo, Jenjira Chalerm, Anupriya Tripathi, Chumpol Ngamphiw, Sissades Tongsima, Rob Knight, Kittiphong Paiboonsukwong, Suthat Fucharoen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Recent research highlights the significant impact of the gut microbiota on health and disease. Thalassemia, a hereditary blood disorder, requires regular blood transfusions, leading to an accumulation of iron in the body. Such changes could
Externí odkaz:
https://doaj.org/article/de50247727aa416fb534177dbb675452
Autor:
Kunapa Iam-arunthai, Tawatchai Suwanban, Pravinwan Thungthong, Supat Chamnanchanunt, Suthat Fucharoen
Publikováno v:
Frontiers in Hematology, Vol 3 (2024)
BackgroundThalassemia is a genetic hemoglobinopathy in which a defective globin chain can cause transfusion-dependent anemia and other complications. As genotype interactions lead to variations in the clinical course among patients with thalassemia,
Externí odkaz:
https://doaj.org/article/b39e6db10f134fec99b3c80fdc366043
Autor:
Pirut Tong-ngam, Wasinee Wongkummool, Phitchapa Pongpaksupasin, Nongnaphat Rawara, Duangnapa Kovanich, Narisorn Kitiyanant, Thongperm Munkongdee, Kittiphong Paiboonsukwong, Suthat Fucharoen, Alisa Tubsuwan
Publikováno v:
Stem Cell Research, Vol 73, Iss , Pp 103228- (2023)
Hemoglobin E (HbE), a common variant in Southeast Asian populations, results from a G to A substitution at codon 26 of the HBB gene, causing abnormal Hb and mild β-thalassemia-like symptoms. Here, we derived an induced pluripotent stem cell (iPSC) l
Externí odkaz:
https://doaj.org/article/7051fa372e814cda8b01e2f7ad0576b3
Autor:
Duantida Songdej, Suthat Fucharoen
Publikováno v:
Thalassemia Reports, Vol 12, Iss 4, Pp 157-172 (2022)
One of the more common single-gene disorders worldwide is α-thalassemia, carriers of which are found at variable frequencies (>1%) across all tropical and subtropical countries. Two linked α-globin genes on each allele of chromosome 16 regulate α-
Externí odkaz:
https://doaj.org/article/7cfb6191d72d4088ab7a288c8cb305c9
Autor:
Thanaporn Pimpakan, Punchalee Mungkalasut, Pornchinee Tansakul, Makamas Chanda, Watcharapong Jugnam-Ang, Supamas Charucharana, Poonlarp Cheepsunthorn, Suthat Fucharoen, Santi Punnahitananda, Chalisa Louicharoen Cheepsunthorn
Publikováno v:
BMC Pediatrics, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Background Screening for G6PD deficiency in newborns can help prevent severe hemolysis, hyperbilirubinemia, and bilirubin encephalopathy, as recommended by the World Health Organization (WHO). It has been speculated that the presence of a hi
Externí odkaz:
https://doaj.org/article/0837ecb96c3a4283abfe76ac391c651f
Autor:
Pornthip Chaichompoo, Ramaneeya Nithipongvanitch, Wasinee Kheansaard, Alisa Tubsuwan, Kanitta Srinoun, Jim Vadolas, Suthat Fucharoen, Duncan R. Smith, Pranee Winichagoon, Saovaros Svasti
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract β-Thalassaemia results from defects in β-globin chain production, leading to ineffective erythropoiesis and subsequently to severe anaemia and other complications. Apoptosis and autophagy are the main pathways that regulate the balance bet
Externí odkaz:
https://doaj.org/article/5eee62b0838c4b4783466c277176815b
Autor:
Rattanawan Thubthed, Sirikwan Siriworadetkun, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Neutrophil dysfunction contributes to a high susceptibility to severe bacterial infection which is a leading cause of morbidity and mortality in β-thalassaemia/HbE, especially in splenectomised patients. This study demonstrated another abno
Externí odkaz:
https://doaj.org/article/caf3a5a76ece41f18cc172fbf6fe2188
Autor:
Sukanya Chumchuen, Orapan Sripichai, Natee Jearawiriyapaisarn, Suthat Fucharoen, Chayanon Peerapittayamongkol
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0281059 (2023)
Imbalanced globin chain output contributes to thalassemia pathophysiology. Hence, induction of fetal hemoglobin in β-thalassemia and other β-hemoglobinopathies are of continuing interest for therapeutic approaches. Genome-wide association studies h
Externí odkaz:
https://doaj.org/article/8e464e9501f443a9a400fe86ec02f049
Autor:
Kornvipa Settakorn, Sarawut Kongkarnka, Anchan Chompupoung, Saovaros Svasti, Suthat Fucharoen, John B. Porter, Somdet Srichairatanakool, Pimpisid Koonyosying
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
β-Thalassemia is characterized by ineffective erythropoiesis leading to chronic anemia. Thus, increased iron absorption from the duodenum and via blood transfusions is required to maintain normal blood hemoglobin (Hb) levels and iron chelators in th
Externí odkaz:
https://doaj.org/article/e5ba8c85dd244e7494910c7eb24a8e09
Autor:
Wasinee Wongkummool, Pirut Tong-ngam, Thongperm Munkongdee, Amornrat Tangprasittipap, Kittiphong Paiboonsukwong, Suradej Hongeng, Suthat Fucharoen, Pimlak Charoenkwan, Alisa Tubsuwan
Publikováno v:
Stem Cell Research, Vol 65, Iss , Pp 102979- (2022)
Hemoglobin Constant Spring (HbCS) is unstable hemoglobin resulting from a nucleotide substitution at the termination codon of the HBA2 gene (c.427 T > C). The homozygous state for HbCS is non-transfusion dependent in adults. Nevertheless, severe anem
Externí odkaz:
https://doaj.org/article/8730a4909dbe49a19074434f86306681