Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Susy C. Kohout"'
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
The voltage-sensing phosphatase (VSP) is the first example of an enzyme controlled by changes in membrane potential. VSP has four distinct regions: the transmembrane voltage-sensing domain (VSD), the inter-domain linker, the cytosolic catalytic domai
Externí odkaz:
https://doaj.org/article/de0bbd42031747c9aa5efb837b7b7bd5
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0209056 (2019)
Voltage-sensing phosphatases (VSPs) are transmembrane proteins that couple changes in membrane potential to hydrolysis of inositol signaling lipids. VSPs catalyze the dephosphorylation of phosphatidylinositol phosphates (PIPs) that regulate diverse a
Externí odkaz:
https://doaj.org/article/980c0434a8824052bedbf931eb5bc7da
Publikováno v:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a243c19d0cefbfeba9da5dc595bfd76d
https://doi.org/10.1117/12.2579348
https://doi.org/10.1117/12.2579348
Publikováno v:
The Journal of General Physiology
The Ciona intestinalis voltage-sensing phosphatase (Ci-VSP) was not thought to multimerize. Rayaprolu et al. show that Ci-VSP exists as a dimer and that this interaction lowers the voltage dependence of activation and alters substrate specificity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38da0de8d55454eb0aa2beb2adb5865f
https://doi.org/10.1085/jgp.201812064
https://doi.org/10.1085/jgp.201812064
Autor:
Vamseedhar Rayaprolu, William J. Ratzan, John Kelley, Guillaume Sandoz, Susy C. Kohout, Joshua A. Davisson
Publikováno v:
Biophysical Journal. 120:158a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3628ee093981d64b27e09e10c8d8023f
https://doi.org/10.1016/j.bpj.2020.11.1137
https://doi.org/10.1016/j.bpj.2020.11.1137
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0209056 (2019)
Voltage-sensing phosphatases (VSPs) are transmembrane proteins that couple changes in membrane potential to hydrolysis of inositol signaling lipids. VSPs catalyze the dephosphorylation of phosphatidylinositol phosphates (PIPs) that regulate diverse a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7b74300339fa875d811ada00898f08
https://doi.org/10.1101/483743
https://doi.org/10.1101/483743
Autor:
Susy C. Kohout, Ehud Y. Isacoff, Christopher R. Kimberlin, Qiang Xu, Lijun Liu, Daniel L. Minor, Simone Müller
Publikováno v:
Minor, Daniel; Liu, L; Kohout, SC; Xu, Q; Müller, S; Kimberlin, CR; et al.(2012). A glutamate switch controls voltage-sensitive phosphatase function. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1c74r865
Nature structural & molecular biology
Nature structural & molecular biology
The Ciona intestinalis voltage-sensing phosphatase (Ci-VSP) couples a voltage-sensing domain (VSD) to a lipid phosphatase that is similar to the tumor suppressor PTEN. How the VSD controls enzyme function has been unclear. Here, we present high-resol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cb9f02217e5e3a4d5444c7fc2046d7
https://doi.org/10.1038/nsmb.2289
https://doi.org/10.1038/nsmb.2289
Publikováno v:
Nature chemical biology
In the voltage-sensing phosphatase Ci-VSP, a voltage-sensing domain (VSD) controls a lipid phosphatase domain (PD). The mechanism by which the domains are allosterically coupled is not well understood. Using an in vivo assay, we found that the interd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2ad8c77b5af228a09e35b9366d4895
http://europepmc.org/articles/PMC2857593
http://europepmc.org/articles/PMC2857593
Publikováno v:
Biophysical Journal. 114:476a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a23459571927a7cc23bac12c9b33e213
https://doi.org/10.1016/j.bpj.2017.11.2617
https://doi.org/10.1016/j.bpj.2017.11.2617
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::3c2e930ed73c7eb89f7716f4bc44a70d
http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00142/full
http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00142/full