Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Susumu Nakade"'
Autor:
Junsaku Kitagawa, Hayato Arai, Hiroyuki Iida, Jiro Mukai, Kenji Furukawa, Seitaro Ohtsu, Susumu Nakade, Tomohiro Hikima, Miwa Haranaka, Naoto Uemura
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1967-1976 (2021)
Abstract Camostat mesylate, an oral serine protease inhibitor, is used to treat chronic pancreatitis and reflux esophagitis. Recently, camostat mesylate and its active metabolite 4‐(4‐guanidinobenzoyloxy)phenylacetic acid (GBPA) were reported to
Externí odkaz:
https://doaj.org/article/f1376106677341e6ac6e9becf4c1fc0c
Autor:
Ryosuke Inoue, Takahide Teramoto, Susumu Nakade, Hiroyuki Okamoto, Eiji Yukawa, Shun Higuchi, Naomi Kondo, Haruki Mikawa
Publikováno v:
Allergology International, Vol 52, Iss 4, Pp 213-218 (2003)
Background: This is the first report about the pharmacokinetics (PK) of pranlukast in children. The aim of the present study was to assess the PK parameters of pranlukast in children and to compare them with those in adults. Methods: Six healthy adul
Externí odkaz:
https://doaj.org/article/be47850269bd48de8ce78c5445e79918
Autor:
Susumu Nakade, Shyh Yuh Liou
Publikováno v:
Folia Pharmacologica Japonica. 148:290-295
Autor:
Akio Yamagishi, Kazuo Matsubara, Susumu Nakade, Atsushi Kurosawa, Manabu Suno, Takayuki Kunisawa, Ryunosuke Higashi, Ami Sugawara, Hiroshi Iwasaki
Publikováno v:
Journal of Anesthesia. 29(2):198-205
PURPOSE: We previously determined the pharmacokinetic (PK) parameters of landiolol in healthy male volunteers. In this study, we evaluated the usefulness of target-controlled infusion (TCI) of landiolol hydrochloride and determined PK parameters of l
Publikováno v:
Biopharmaceutics & Drug Disposition. 31:396-406
The pharmacokinetic (PK) and pharmacodynamic (PD) parameters of ONO-4641 in humans were estimated using preclinical data in order to provide essential information to better design future clinical studies. The characterization of PK/PD was measured in
Autor:
Junji Komaba, Dai Matsuda, Yoshitaka Hashimoto, Yasuyuki Miyata, Kimio Shibakawa, Mikio Ogawa, Susumu Nakade
Publikováno v:
Biomedical Chromatography. 23:315-323
We developed and validated an on-line reverse-phase two-dimensional LC/MS/MS (2D-LC/MS/MS) system for simultaneous determination of the levels of prostaglandin (PG) E(2) as well as PGF(2alpha) and its metabolite 13,14-dihydro-15-keto PGF(2alpha) (F(2
Autor:
Mikio Ogawa, Tomoya Ohno, Susumu Nakade, Junsaku Kitagawa, Yasuo Kodama, Naoki Honda, Akinori Yamauchi, Chihiro Amano
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 40:287-293
We analyzed the current status of clinical pharmacokinetic (PK) studies in new drug applications (NDA) by evaluating 17 cardiovascular (CV) drugs that were approved between 2000 and 2007 in Japan since CV drugs were one of the largest categories to b
Publikováno v:
Journal of Chromatography B. 869:126-132
To evaluate the pharmacokinetics of digoxin in humans, a sensitive and specific LC/MS/MS method was developed and validated for the determination of digoxin concentrations in human plasma. The method was shown to be more sensitive, specific, accurate
Autor:
Yasuyuki Miyata, Tomoya Ohno, Kazuki Nakayama, Junsaku Kitagawa, Susumu Nakade, Hiroyuki Miyabe, Shinya Ueda, Akihiro Ohnishi
Publikováno v:
The Journal of Clinical Pharmacology. 48:330-334
The effect of itraconazole, a potent inhibitor of the CYP3A isoenzyme family, on the pharmacokinetics of imidafenacin, a novel synthetic muscarinic receptor antagonist, was investigated. Twelve healthy subjects participated in this open-label, self-c
Autor:
Hiroyuki Miyabe, Susumu Nakade, Yasuyuki Miyata, Shinya Ueda, Junsaku Kitagawa, Yuichi Masuda, Tomoya Ohno, Kazuki Nakayama
Publikováno v:
British Journal of Clinical Pharmacology. 65:197-202
What is already known about this subject • The absolute bioavailability of imidafenacin in rats and dogs is 5.6% and 36.1%, respectively. • The pharmacokinetic profiles of imidafenacin after oral administration have been revealed. • Imidafenaci