Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Susumu Kohno"'
Autor:
Kayo Kayahashi, Mahadi Hasan, Anowara Khatun, Susumu Kohno, Jumpei Terakawa, Shin-ichi Horike, Natsumi Toyoda, Ayumi Matsuoka, Takashi Iizuka, Takeshi Obata, Masanori Ono, Yasunari Mizumoto, Chiaki Takahashi, Hiroshi Fujiwara, Takiko Daikoku
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Although low estrogen is considered to suppress uterine endometrial carcinoma, the most cases occur in the postmenopausal stage. After menopause, the production of androgen level also declines. Therefore, to resolve the above enigma, we hypo
Externí odkaz:
https://doaj.org/article/9fafabd61fc54d52afeec3f10740b98f
Autor:
Shogo Maruzen, Seiichi Munesue, Mitsuyoshi Okazaki, Satoshi Takada, Shinichi Nakanuma, Isamu Makino, Linxiang Gong, Susumu Kohno, Chiaki Takahashi, Hidehiro Tajima, Yasuhiko Yamamoto, Shintaro Yagi
Publikováno v:
Onco, Vol 4, Iss 2, Pp 77-86 (2024)
Although pancreatic neuroendocrine neoplasms (panNENs) are much less common and have a better prognosis than exocrine pancreatic cancers, their recurrence rate is not low, even in Grade 1 (World Health Organization classification) panNEN. Recently, t
Externí odkaz:
https://doaj.org/article/07262afaca4441f986249be1464e7ebd
Autor:
Nobuhiro Okada, Chihiro Ueki, Masahiro Shimazaki, Goki Tsujimoto, Susumu Kohno, Hayato Muranaka, Kiyotsugu Yoshikawa, Chiaki Takahashi
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Two splicing variants exist in NFYA that exhibit high expression in many human tumour types. The balance in their expression correlates with prognosis in breast cancer, but functional differences remain unclear. Here, we demonstrate that NFY
Externí odkaz:
https://doaj.org/article/0cdf57dd07fe49f4b2d2a70da5e08099
Autor:
Masafumi Noguchi, Susumu Kohno, Anna Pellattiero, Yukino Machida, Keitaro Shibata, Norihito Shintani, Takashi Kohno, Noriko Gotoh, Chiaki Takahashi, Atsushi Hirao, Luca Scorrano, Atsuko Kasahara
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-10 (2023)
Abstract Drug resistance limits the efficacy of chemotherapy and targeted cancer treatments, calling for the identification of druggable targets to overcome it. Here we show that the mitochondria-shaping protein Opa1 participates in resistance agains
Externí odkaz:
https://doaj.org/article/6a7026ae169d4bc08f2cf62f5c09d36c
Autor:
Tomiyasu Murata, Kazunori Hashimoto, Susumu Kohno, Chiaki Takahashi, Masayoshi Yamaguchi, Chihiro Ito, Itoigawa Masataka, Roji Kojima, Kiyomi Hikita, Norio Kaneda
Publikováno v:
FEBS Open Bio, Vol 12, Iss 1, Pp 175-191 (2022)
We previously isolated derrisfolin A, a novel rotenoid derivative, from the stems of Derris trifoliata Lour. (Leguminosae). Here, we report that derrisfolin A induces the expression of endogenous regucalcin (RGN) protein in both pancreatic MIN6 β‐
Externí odkaz:
https://doaj.org/article/baf86eeca3ab4a7ab2eab73513c8ef84
Autor:
Naho Nomura, Chiaki Ito, Takako Ooshio, Yuko Tadokoro, Susumu Kohno, Masaya Ueno, Masahiko Kobayashi, Atsuko Kasahara, Yusuke Takase, Kenta Kurayoshi, Sha Si, Chiaki Takahashi, Masaaki Komatsu, Toru Yanagawa, Atsushi Hirao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Autophagy is a cellular degradation system contributing to homeostasis of tissue stem cells including haematopoietic stem cells (HSCs). It plays pleiotropic roles in HSC characteristics throughout life, but its stage-specific roles in HSC se
Externí odkaz:
https://doaj.org/article/9b2889ffac5248b398987d01765c8ab0
Autor:
Tomiyasu Murata, Masayoshi Yamaguchi, Susumu Kohno, Chiaki Takahashi, Watanabe Risa, Kanna Hatori, Kiyomi Hikita, Norio Kaneda
Publikováno v:
FEBS Open Bio, Vol 10, Iss 10, Pp 1967-1984 (2020)
Dysregulation of adipocyte differentiation and dysfunction play key roles in the pathogenesis of obesity and associated disorders such as diabetes and metabolic syndrome, and as such, a better understanding of the molecular mechanism of adipogenesis
Externí odkaz:
https://doaj.org/article/6881663430554862a0e94bd3d5ef4c29
Autor:
Paing Linn, Susumu Kohno, Jindan Sheng, Nilakshi Kulathunga, Hai Yu, Zhiheng Zhang, Dominic Voon, Yoshihiro Watanabe, Chiaki Takahashi
Publikováno v:
Cancers, Vol 13, Iss 15, p 3737 (2021)
Retinoblastoma protein 1 (RB1) is encoded by a tumor suppressor gene that was discovered more than 30 years ago. Almost all mitogenic signals promote cell cycle progression by braking on the function of RB1 protein through mono- and subsequent hyper-
Externí odkaz:
https://doaj.org/article/0a5a8aacf3624481a320a937bed8b01a
Autor:
Loc Thi Pham, Hui Peng, Masaya Ueno, Susumu Kohno, Atuso Kasada, Kazuyoshi Hosomichi, Takehiro Sato, Kenta Kurayoshi, Masahiko Kobayashi, Yuko Tadokoro, Atsuko Kasahara, Mahmoud I. Shoulkamy, Bo Xiao, Paul F. Worley, Chiaki Takahashi, Atsushi Tajima, Atsushi Hirao
Publikováno v:
Biochemical and Biophysical Research Communications. 621:74-79
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of immature T lymphocytes. Although various therapeutic approaches have been developed, refractoriness of chemotherapy and relapse cause a poor prognosis of the disease and furth
Autor:
Chiaki Takahashi, Naofumi Mukaida, David A. Barbie, Tomoaki Tanaka, Takumi Nishiuchi, Tran C. Thai, Sayuri Masuda, Misa Suzuki, Naoko Nagatani, Hayato Muranaka, Yuuki Nishimoto, Nobuhiro Okada, Soichiro Sasaki, Shoichiro Tange, Akiyo Yoshida, Susumu Kohno, Shunsuke Kitajima, Fengkai Li
Cancer cell–intrinsic properties caused by oncogenic mutations have been well characterized; however, how specific oncogenes and tumor suppressors impact the tumor microenvironment (TME) is not well understood. Here, we present a novel non–cell-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac998a90c206d514052bd830826b79dd
https://doi.org/10.1158/0008-5472.c.6510716
https://doi.org/10.1158/0008-5472.c.6510716