Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Susumu Fujisawa"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 4, Pp 267-274 (2016)
The lower esophageal sphincter (LES) is a specialized region of the esophageal smooth muscle that allows the passage of a swallowed bolus into the stomach. Nitric oxide (NO) plays a major role in LES relaxation. Nicorandil possesses dual properties o
Externí odkaz:
https://doaj.org/article/f7799c18d17d4753b3fb82f56fe3c717
Autor:
Maiko Hongo, Susumu Fujisawa, Takeshi Adachi, Tomonori Shimbo, Shigehiro Shibata, Takayoshi Ohba, Kyoichi Ono
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 2, Pp 118-125 (2016)
Dexmedetomidine is a selective α2 adrenergic agonist. Although dexmedetomidine is widely used for sedation and analgesia, it frequently produces hypotension and bradycardia. The present study aimed to evaluate the effects of dexmedetomidine on cardi
Externí odkaz:
https://doaj.org/article/53cad60834fc4662aafed81896853a15
Autor:
Takeshi Adachi, Shigehiro Shibata, Maiko Hongo, Tomonori Shimbo, Kyoichi Ono, Takayoshi Ohba, Susumu Fujisawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 2, Pp 118-125 (2016)
Dexmedetomidine is a selective α2 adrenergic agonist. Although dexmedetomidine is widely used for sedation and analgesia, it frequently produces hypotension and bradycardia. The present study aimed to evaluate the effects of dexmedetomidine on cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d6c921dd87a79c823d045b798747e7
https://doi.org/10.1016/j.jphs.2016.05.002
https://doi.org/10.1016/j.jphs.2016.05.002
Publikováno v:
Journal of Advanced Therapies and Medical Innovation Sciences. 1
Background: Myocardial motion produces compression waves that are transmitted to the surface of the chest and vibrate the chest wall. Piezoelectric transducers, which detect mechanical vibrations, may be useful for evaluating cardiac and/or breathing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a497a612d15cd03042ea1fdf7c571a14
https://doi.org/10.17987/jatamis.v1i0.207
https://doi.org/10.17987/jatamis.v1i0.207
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 4, Pp 267-274 (2016)
The lower esophageal sphincter (LES) is a specialized region of the esophageal smooth muscle that allows the passage of a swallowed bolus into the stomach. Nitric oxide (NO) plays a major role in LES relaxation. Nicorandil possesses dual properties o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d580fd8b8f9eb6370db71bd52b70b6ba
https://pubmed.ncbi.nlm.nih.gov/27562702
https://pubmed.ncbi.nlm.nih.gov/27562702
Autor:
Ken Okumura, Kazuhiko Seya, Ken-Ichi Furukawa, Kyoichi Ono, Shigeru Motomura, Susumu Fujisawa
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 344:77-84
Previously, we showed that in adult rat cardiomyocytes, nitric oxide (NO) donors stimulate mitochondrial cGMP production, followed by cytochrome c release, independently of the mitochondrial permeable transition pore. We investigated whether mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5673442d76c13fd72cb2c34b5e3482f0
https://doi.org/10.1124/jpet.112.198176
https://doi.org/10.1124/jpet.112.198176
Autor:
Hiroshi Ito, Ichiro Miyoshi, Susumu Fujisawa, Takashi Suzuki, Eiki Takahashi, Hiroyuki Watanabe, Hironobu Sasano, Manabu Murakami, Kyoichi Ono, Toshihiko Iijima, Takayoshi Ohba, Tsai Wen Wu, Yoichiro Takahashi
Publikováno v:
Biochemical and Biophysical Research Communications. 354:1016-1020
To elucidate the physiological importance of neuronal (N)-type calcium channels in sympathetic controls, we analyzed N-type channel-deficient (NKO) mice. Immunoprecipitation analysis revealed increased interaction between β3 (a major accessory subun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80a7223e7dcd34405b6ecae2004339c
https://doi.org/10.1016/j.bbrc.2007.01.087
https://doi.org/10.1016/j.bbrc.2007.01.087
Autor:
Tomonori Shimbo, M Hongo, Susumu Fujisawa, Takeshi Adachi, Takayoshi Ohba, Kyoichi Ono, Shigehiro Shibata
Publikováno v:
Intensive Care Medicine Experimental
Dexmedetomidine is a potent and selective alpha-2 agonist, and is widely used for not only an adjunct to anesthesia but also sedation during mechanical ventilation in intensive care unit. It has been reported that, although the substance does not app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf39238b4cf52da6ef7fb63be73edd4
https://doi.org/10.1186/2197-425x-2-s1-p89
https://doi.org/10.1186/2197-425x-2-s1-p89
Publikováno v:
British Journal of Pharmacology. 129:1007-1013
The slowly activating delayed rectifier K+ current (IKs) was recorded in single myocytes dissociated from guinea-pig ventricles and the mechanism underlying the block of IKs by a chromanol derivative, 293B, was investigated. In the presence of 1–10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69ddd9d040a75a8c44bade086ad5aa51
https://doi.org/10.1038/sj.bjp.0703126
https://doi.org/10.1038/sj.bjp.0703126
Autor:
Toshihiko Iijima, Susumu Fujisawa
Publikováno v:
Japanese Journal of Pharmacology. 81:309-312
Arginine vasopressin (AVP) (0.03-3 microM) produced transient negative responses that were followed by slowly developing positive inotropic responses in guinea pig papillary muscles. The inotropic responses were antagonized by OPC-21268 (10 microM),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c280da95a2d466b8041ff3ab978a677
https://doi.org/10.1016/s0021-5198(19)30770-x
https://doi.org/10.1016/s0021-5198(19)30770-x