Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Susumu, Tomita"'
Autor:
Asuka Tsuzuki, Miwako Yamasaki, Kohtarou Konno, Taisuke Miyazaki, Norio Takei, Susumu Tomita, Michisuke Yuzaki, Masahiko Watanabe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related behaviors. This pathway is particularly enriched in nAChR α3 and β4 subunits, both of w
Externí odkaz:
https://doaj.org/article/41a33e14caa64b7481b65fa5e3c29b45
Autor:
Joongkyu Park, Coralie Berthoux, Erika Hoyos-Ramirez, Lili Shan, Megumi Morimoto-Tomita, Yixiang Wang, Pablo E. Castillo, Susumu Tomita
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112826- (2023)
Summary: Long-term potentiation (LTP), a well-characterized form of synaptic plasticity, is believed to underlie memory formation. Hebbian, postsynaptically expressed LTP requires TARPγ-8 phosphorylation for synaptic insertion of AMPA receptors (AMP
Externí odkaz:
https://doaj.org/article/056d9dfb866b44288d9b32f21a919b0d
Autor:
Erica L Gorenberg, Sofia Massaro Tieze, Betül Yücel, Helen R Zhao, Vicky Chou, Gregory S Wirak, Susumu Tomita, TuKiet T Lam, Sreeganga S Chandra
Publikováno v:
PLoS Biology, Vol 20, Iss 3, p e3001590 (2022)
Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation
Externí odkaz:
https://doaj.org/article/2b17440e1d874180bbcb43c2eb4e0aab
Autor:
Taisuke Miyazaki, Megumi Morimoto-Tomita, Coralie Berthoux, Kotaro Konno, Yoav Noam, Tokiwa Yamasaki, Matthijs Verhage, Pablo E Castillo, Masahiko Watanabe, Susumu Tomita
Publikováno v:
eLife, Vol 10 (2021)
Ionotropic neurotransmitter receptors at postsynapses mediate fast synaptic transmission upon binding of the neurotransmitter. Post- and trans-synaptic mechanisms through cytosolic, membrane, and secreted proteins have been proposed to localize neuro
Externí odkaz:
https://doaj.org/article/3b79b81fc19f4bc9932739ee9bebb0d2
Autor:
Matthew N. McCarroll, Leo Gendelev, Reid Kinser, Jack Taylor, Giancarlo Bruni, Douglas Myers-Turnbull, Cole Helsell, Amanda Carbajal, Capria Rinaldi, Hye Jin Kang, Jung Ho Gong, Jason K. Sello, Susumu Tomita, Randall T. Peterson, Michael J. Keiser, David Kokel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Some anesthetics despite being generally associated with sedation, can also increase brain activity—a phenomenon called paradoxical excitation. The authors identified dozens of compounds that generally decrease neuronal activity, but increase activ
Externí odkaz:
https://doaj.org/article/800557a8a9ec49a7a80e98ddf53a8be2
Autor:
Yusuke Sakai, Haiyan Li, Hiromichi Inaba, Yuki Funayama, Erina Ishimori, Ayako Kawatake-Kuno, Hirotaka Yamagata, Tomoe Seki, Teruyuki Hobara, Shin Nakagawa, Yoshifumi Watanabe, Susumu Tomita, Toshiya Murai, Shusaku Uchida
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102504- (2021)
Summary: Although stressful events predispose individuals to psychiatric disorders, such as depression, not all people who undergo a stressful life experience become depressed, suggesting that gene-environment interactions (GxE) determine depression
Externí odkaz:
https://doaj.org/article/7fe32a45ffdc4b9bb909951c4d0fae33
Autor:
Elizabeth J. Salm, Patrick J. Dunn, Lili Shan, Miwako Yamasaki, Nathalie M. Malewicz, Taisuke Miyazaki, Joongkyu Park, Akio Sumioka, R. Richard L. Hamer, Wei-Wu He, Megumi Morimoto-Tomita, Robert H. LaMotte, Susumu Tomita
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: Fast purinergic signaling is mediated by ATP and ATP-gated ionotropic P2X receptors (P2XRs), and it is implicated in pain-related behaviors. The properties exhibited by P2XRs vary between those expressed in heterologous cells and in vivo. Se
Externí odkaz:
https://doaj.org/article/989eda6db00a41328abe0881dd92de9a
Autor:
Qingzhen, Yu, Katsushi, Kumata, Jian, Rong, Zhen, Chen, Tomoteru, Yamasaki, Jiahui, Chen, Zhiwei, Xiao, Hideki, Ishii, Atsuto, Hiraishi, Tuo, Shao, Zhang, Yiding, Kuan, Hu, Lin, Xie, Masayuki, Fujinaga, Chunyu, Zhao, Wakana, Mori, Thomas, Collier, Ahmed, Haider, Susumu, Tomita, Zhang, Ming-Rong, Steven, Liang
Publikováno v:
Journal of Medicinal Chemistry. 65(13):9144-9158
The transmembrane α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptor regulatory protein γ-8 (TARP γ-8) constitutes an auxiliary subunit of AMPA receptors, which mediates various brain functions including learning and memory. TAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::3fe8a6368fdf324ade97aae548b553ce
https://repo.qst.go.jp/records/86471
https://repo.qst.go.jp/records/86471
Autor:
Christoph Straub, Yoav Noam, Toshihiro Nomura, Miwako Yamasaki, Dan Yan, Herman B. Fernandes, Ping Zhang, James R. Howe, Masahiko Watanabe, Anis Contractor, Susumu Tomita
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 531-544 (2016)
Synaptic communication between neurons requires the precise localization of neurotransmitter receptors to the correct synapse type. Kainate-type glutamate receptors restrict synaptic localization that is determined by the afferent presynaptic connect
Externí odkaz:
https://doaj.org/article/107a1aa316a04f4db9a8de0087bb6ac0
Autor:
Nadine Erlenhardt, Hong Yu, Kavitha Abiraman, Tokiwa Yamasaki, Jacques I. Wadiche, Susumu Tomita, David S. Bredt
Publikováno v:
Cell Reports, Vol 14, Iss 4, Pp 782-794 (2016)
AMPA receptor (AMPAR) complexes contain auxiliary subunits that modulate receptor trafficking and gating. In addition to the transmembrane AMPAR regulatory proteins (TARPs) and cornichons (CNIH-2/3), recent proteomic studies identified a diverse arra
Externí odkaz:
https://doaj.org/article/31424928f3ca4ecd969e75b3ca3eac5d