Výsledky vyhledávání - "Susumu, Takekoshi"

Akademický článek

Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3 × Tg-AD mice

Autor: Fumiko Konishi, Tadasu Furusho, Yoshiyuki Soeda, Jun Yamauchi, Shoko Kobayashi, Masatoshi Ito, Takuma Araki, Sarasa Kogure, Akihiko Takashima, Susumu Takekoshi

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of extracellular amyloid-beta peptides (Aβ) resulting in senile plaques and intracellular hyperphosphorylated tau protein resulting in neurofibrill

Externí odkaz: https://doaj.org/article/13a35b293fc84c849041f2bd9c826ac3

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Akademický článek

Structural aging of human neurons is opposite of the changes in schizophrenia.

Publikováno v: PLoS ONE, Vol 18, Iss 6, p e0287646 (2023)

Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from ei

Externí odkaz: https://doaj.org/article/71bdf97d2e48499f88528c2d0a20207d

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Akademický článek

Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures

Autor: Rino Saiga, Masayuki Uesugi, Akihisa Takeuchi, Kentaro Uesugi, Yoshio Suzuki, Susumu Takekoshi, Chie Inomoto, Naoya Nakamura, Youta Torii, Itaru Kushima, Shuji Iritani, Norio Ozaki, Kenichi Oshima, Masanari Itokawa, Makoto Arai, Ryuta Mizutani

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Brain blood vessels constitute a micrometer-scale vascular network responsible for supply of oxygen and nutrition. In this study, we analyzed cerebral tissues of the anterior cingulate cortex and superior temporal gyrus of schizophrenia case

Externí odkaz: https://doaj.org/article/013403da8f0945d4a4dc7c9259d385f8

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Akademický článek

Structural diverseness of neurons between brain areas and between cases

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract The cerebral cortex is composed of multiple cortical areas that exert a wide variety of brain functions. Although human brain neurons are genetically and areally mosaic, the three-dimensional structural differences between neurons in differe

Externí odkaz: https://doaj.org/article/3f4953f4dd354eb280a04eb6bec87a5f

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Cellular Uptake of Pyrroloquinoline Quinone in Its Intact and Derivatized Forms from the Cell Culture Medium of 3T3-L1

Autor: Chikara Kato, Isabella Supardi Parida, Satoshi Maeda, Tsuyoshi Mikekado, Shunji Kato, Susumu Takekoshi, Kiyotaka Nakagawa

Publikováno v: Journal of Oleo Science. 71:1761-1767

Following a growing interest in the physiological effects of pyrroloquinoline quinone (PQQ), more cell culture experiments have begun to elucidate its mechanism of action. However, to our knowledge, no reports have used instrumental analysis, such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760248d9b3b3a5750c69ea115ad6dcea
https://doi.org/10.5650/jos.ess22284

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Cellular level of coenzyme Q increases with neuronal differentiation, playing an important role in neural elongations

Autor: Akari, Nakamura, Mizuho, Okamoto, Ayaka, Maeda, Huiyu, Jiang, Kyosuke, Sugawara, Kanae, Kitatani, Susumu, Takekoshi, Akio, Fujisawa, Yorihiro, Yamamoto, Misato, Kashiba

Publikováno v: Journal of Clinical Biochemistry and Nutrition. 71:89-96

Deficiency of coenzyme Q has been reported in various neuro-logical diseases, and the behavior of this lipid in neurons has attracted attention. However, the behavior of this lipid in normal neurons remains unclear. In this study, we analyzed the con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a51767fa3ba7d6caa292b9f20199054
https://doi.org/10.3164/jcbn.21-107

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Protective effect of ebselen on bleomycin-induced lung fibrosis: analysis of the molecular mechanism of lung fibrosis mediated by oxidized diacylglycerol

Autor: Hidehiko Yagasaki, Susumu Takekoshi, Kanae Kitatani, Chikara Kato, Hiroyuki Yamasaki, Kie Shioyama, Takaaki Tsuboi, Tomohiko Matsuzaki, Yutaka Inagaki, Ryota Masuda, Masayuki Iwazaki

Publikováno v: Free radical research.

The molecular mechanisms underlying the development of pulmonary fibrosis remain unknown, and effective treatments have not yet been developed. It has been shown that oxidative stress is involved in lung fibrosis. Oxidized diacylglycerol (DAG) produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b07cfd0475e607bcfb660fc4a5f3fd
https://pubmed.ncbi.nlm.nih.gov/36562703

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Possible Glutathione Peroxidase 4-Independent Reduction of Phosphatidylcholine Hydroperoxide: Its Relevance to Ferroptosis

Autor: Chikara Kato, Yuuri Suzuki, Isabella Supardi Parida, Shunji Kato, Hiroyuki Yamasaki, Susumu Takekoshi, Kiyotaka Nakagawa

Publikováno v: Journal of oleo science. 71(11)

Ferroptosis is mainly caused by iron-mediated peroxidation of phospholipids and has recently attracted attention due to its involvement in various diseases. At the center of it is supposedly the inability of glutathione peroxidase 4 (GPX4) to reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656d274e63a39ee3e02152113bf18e5d
https://pubmed.ncbi.nlm.nih.gov/36198586

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