Zobrazeno 1 - 10
of 449
pro vyhledávání: '"Susumu, Seino"'
Autor:
Quan Yingyue, Kenji Sugawara, Harumi Takahashi, Norihide Yokoi, Kento Ohbayashi, Yusaku Iwasaki, Susumu Seino, Wataru Ogawa
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 6, Pp 746-755 (2023)
ABSTRACT Aims/Introduction Imeglimin is a new antidiabetic drug structurally related to metformin. Despite this structural similarity, only imeglimin augments glucose‐stimulated insulin secretion (GSIS), with the mechanism underlying this effect re
Externí odkaz:
https://doaj.org/article/912c73cff87a4997a1cfa1af12cf59fa
Autor:
Guirong Han, Harumi Takahashi, Naoya Murao, Ghupurjan Gheni, Norihide Yokoi, Yoshiyuki Hamamoto, Shun‐ichiro Asahara, Yutaka Seino, Yoshiaki Kido, Susumu Seino
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 6, Pp 920-930 (2021)
Abstract Aims/Introduction Glutamine is the most abundant amino acid in the circulation. In this study, we investigated cell signaling in the amplification of insulin secretion by glutamine. Materials and Methods Clonal pancreatic β‐cells MIN6‐K
Externí odkaz:
https://doaj.org/article/5f31d8d422264d359df183cf9bac2a7e
Autor:
Tomohide Hayami, Norihide Yokoi, Takuro Yamaguchi, Kohei Honda, Naoya Murao, Harumi Takahashi, Shujie Wang, Yusuke Seino, Hideki Kamiya, Daisuke Yabe, Ian R Sweet, Akira Mizoguchi, Jiro Nakamura, Susumu Seino
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 6, Pp 1434-1447 (2020)
Abstract Aims/Introduction Pancreatic islets are heterogenous. To clarify the relationship between islet heterogeneity and incretin action in the islets, we studied gene expression and metabolic profiles of non‐large and enlarged islets of the Zuck
Externí odkaz:
https://doaj.org/article/5890f1d6c1da4df0a98ae5c4ae59e065
Autor:
Naoya Murao, Norihide Yokoi, Harumi Takahashi, Tomohide Hayami, Yasuhiro Minami, Susumu Seino
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101414- (2022)
Objective: Age is a risk factor for type 2 diabetes (T2D). We aimed to elucidate whether β-cell glucose metabolism is altered with aging and contributes to T2D. Methods: We used senescence-accelerated mice (SAM), C57BL/6J (B6) mice, and ob/ob mice a
Externí odkaz:
https://doaj.org/article/a3936d5cd61f4706a23b2a895c3b8b0d
Autor:
Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103609- (2022)
Summary: Glucose-responsive ATP-sensitive potassium channels (KATP) are expressed in a variety of tissues including nervous systems. The depolarization of the membrane potential induced by glucose may lead to hyperexcitability of neurons and induce e
Externí odkaz:
https://doaj.org/article/0afe7a666be9414fb5b914b896d61746
Autor:
Anastassios Karagiannis, Thierry Gallopin, Alexandre Lacroix, Fabrice Plaisier, Juliette Piquet, Hélène Geoffroy, Régine Hepp, Jérémie Naudé, Benjamin Le Gac, Richard Egger, Bertrand Lambolez, Dongdong Li, Jean Rossier, Jochen F Staiger, Hiromi Imamura, Susumu Seino, Jochen Roeper, Bruno Cauli
Publikováno v:
eLife, Vol 10 (2021)
Glucose is the mandatory fuel for the brain, yet the relative contribution of glucose and lactate for neuronal energy metabolism is unclear. We found that increased lactate, but not glucose concentration, enhances the spiking activity of neurons of t
Externí odkaz:
https://doaj.org/article/57bb3a9ac2944ab2882e68666a6d4e9e
Autor:
Masatoshi Murase, Yusuke Seino, Ryuya Maekawa, Atsushi Iida, Kaori Hosokawa, Tomohide Hayami, Shin Tsunekawa, Yoji Hamada, Norihide Yokoi, Susumu Seino, Yoshitaka Hayashi, Hiroshi Arima
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 2, Pp 238-250 (2019)
Abstract Aims/Introduction A high‐carbohydrate diet is known to increase insulin secretion and induce obesity. However, whether or not a high‐carbohydrate diet affects β‐cell mass (BCM) has been little investigated. Materials and Methods Both
Externí odkaz:
https://doaj.org/article/a2e1437fe32748a49166a16dd0b6e4e0
Autor:
Yasuhiro Watanabe, Takashi Kishimoto, Takashi Miki, Susumu Seino, Haruaki Nakaya, Akio Matsumoto
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract We recently reported the reduced ATP-sensitive potassium (KATP) channel activities in the transgenic mouse heart overexpressing the vascular type KATP channel pore-forming subunit (Kir6.1). Although dysfunction of cardiac KATP channel has be
Externí odkaz:
https://doaj.org/article/6102e71ff39e47bda2eca019553263e0
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 1, Pp 37-43 (2017)
Genetic analysis of KCNJ8 has pointed a mutation (S422L) as a susceptible link to J wave syndrome (JWS). In vitro expression study indicated that the ATP-sensitive K+ (KATP) channel with the S422L mutation has the gain-of-function with reduced sensit
Externí odkaz:
https://doaj.org/article/a25f28dfa76c4bc88e64d8b124683ff9
Autor:
Christopher M. Carmean, Susumu Seino
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Type 2 diabetes mellitus (T2DM) is a serious global health problem, currently affecting an estimated 451 million people worldwide. T2DM is characterized by hyperglycemia and low insulin relative to the metabolic demand. The precise contributing facto
Externí odkaz:
https://doaj.org/article/e8cb5237bac148f9b7b83ff17fb8ee79