Characterization of Growth Hormone Signaling in the NCI60 Cancer Panel

Autor: Sustarsic, Elahu Gosney

Growth hormone Receptor (GHR) is a class I cytokine receptor. Under normal conditions, it is expressed in most tissues of the body.In addition to its presence in healthy tissue, GHR has been detected in cancer cells and tumors. There has been accumul

Externí odkaz: http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1375116998

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Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.

Autor: Sveidahl Johansen O; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Embark Biotech ApS, Copenhagen, Denmark; Center for Adipocyte Signaling, University of Southern Denmark, Odense, Denmark., Ma T; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Embark Biotech ApS, Copenhagen, Denmark., Hansen JB; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Embark Biotech ApS, Copenhagen, Denmark., Markussen LK; Center for Adipocyte Signaling, University of Southern Denmark, Odense, Denmark; Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Schreiber R; Institute of Molecular Biosciences, University of Graz, Graz, Austria., Reverte-Salisa L; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany., Dong H; Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland., Christensen DP; Embark Biotech ApS, Copenhagen, Denmark., Sun W; Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland., Gnad T; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany., Karavaeva I; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Nielsen TS; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Kooijman S; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Cero C; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA., Dmytriyeva O; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Shen Y; Institute for Diabetes, Obesity, and Metabolism, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Razzoli M; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA., O'Brien SL; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK; Institute of Pharmacology and Toxicology and Bio-Imaging Center, University of Würzburg, Würzburg, Germany., Kuipers EN; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Nielsen CH; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, Copenhagen, Denmark., Orchard W; MRC Laboratory of Molecular Biology, Cambridge, UK., Willemsen N; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Jespersen NZ; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark., Lundh M; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Sustarsic EG; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Hallgren CM; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Frost M; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., McGonigle S; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA., Isidor MS; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Broholm C; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Hansen JB; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Kjær A; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, Copenhagen, Denmark., Granneman JG; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA., Babu MM; MRC Laboratory of Molecular Biology, Cambridge, UK; Department of Structural Biology and Center for Data Driven Discovery, St. Jude Children's Research Hospital, Memphis, TN, USA., Calebiro D; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK; Institute of Pharmacology and Toxicology and Bio-Imaging Center, University of Würzburg, Würzburg, Germany., Nielsen S; Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark., Rydén M; Department of Medicine (H7), Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden., Soccio R; Institute for Diabetes, Obesity, and Metabolism, Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Rensen PCN; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands., Treebak JT; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Schwartz TW; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Embark Biotech ApS, Copenhagen, Denmark., Emanuelli B; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Bartolomucci A; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA., Pfeifer A; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany., Zechner R; Institute of Molecular Biosciences, University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria., Scheele C; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Mandrup S; Center for Adipocyte Signaling, University of Southern Denmark, Odense, Denmark; Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Gerhart-Hines Z; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Embark Biotech ApS, Copenhagen, Denmark; Center for Adipocyte Signaling, University of Southern Denmark, Odense, Denmark. Electronic address: zpg@sund.ku.dk.

Publikováno v: Cell [Cell] 2021 Jun 24; Vol. 184 (13), pp. 3502-3518.e33. Date of Electronic Publication: 2021 May 27.