Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Susmita Kaushik"'
Autor:
Andreea Manole, Thomas Wong, Amanda Rhee, Sammy Novak, Shao-Ming Chin, Katya Tsimring, Andres Paucar, April Williams, Traci Fang Newmeyer, Simon T. Schafer, Idan Rosh, Susmita Kaushik, Rene Hoffman, Songjie Chen, Guangwen Wang, Michael Snyder, Ana Maria Cuervo, Leo Andrade, Uri Manor, Kevin Lee, Jeffrey R. Jones, Shani Stern, Maria C. Marchetto, Fred H. Gage
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113466- (2023)
Summary: Biallelic mutations in the gene that encodes the enzyme N-glycanase 1 (NGLY1) cause a rare disease with multi-symptomatic features including developmental delay, intellectual disability, neuropathy, and seizures. NGLY1’s activity in human
Externí odkaz:
https://doaj.org/article/e02b3ae04a344993bec4fbd3628df05f
Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD
Autor:
Mark L. Schultz, Kelsey L. Krus, Susmita Kaushik, Derek Dang, Ravi Chopra, Ling Qi, Vikram G. Shakkottai, Ana Maria Cuervo, Andrew P. Lieberman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Niemann-Pick type C1 disease is most commonly caused by the allele NPC1 I1061T, which is misfolded in the ER and rapidly degraded by the ubiquitin proteasome system. Here the authors show that the I1061T mutant is also degraded by ER-phagy.
Externí odkaz:
https://doaj.org/article/fa59083b03654256906367e10286935a
Autor:
Limor Goren, George Zhang, Susmita Kaushik, Paul A S Breslin, Yi-Chieh Nancy Du, David A Foster
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0216024 (2019)
(-)-Oleocanthal (oleocanthal) is a phenolic compound found in varying concentrations in extra virgin olive oil oleocanthal has been shown to be active physiologically, benefiting several diseased states by conferring anti-inflammatory and neuroprotec
Externí odkaz:
https://doaj.org/article/1905d63015cd4cc5b4a63ced88bdc1e1
Autor:
Elvira S. Cannizzo, Cristina C. Clement, Kateryna Morozova, Rut Valdor, Susmita Kaushik, Larissa N. Almeida, Carlo Follo, Ranjit Sahu, Ana Maria Cuervo, Fernando Macian, Laura Santambrogio
Publikováno v:
Cell Reports, Vol 2, Iss 1, Pp 136-149 (2012)
A hallmark of aging is an imbalance between production and clearance of reactive oxygen species and increased levels of oxidatively damaged biomolecules. Herein, we demonstrate that splenic and nodal antigen-presenting cells purified from aging mice
Externí odkaz:
https://doaj.org/article/78b9ac03300842b59d5317be70bdea6d
Autor:
Yves R. Juste, Susmita Kaushik, Mathieu Bourdenx, Ranee Aflakpui, Sanmay Bandyopadhyay, Fernando Garcia, Antonio Diaz, Kristen Lindenau, Vincent Tu, Gregory J. Krause, Maryam Jafari, Rajat Singh, Javier Muñoz, Fernando Macian, Ana Maria Cuervo
Publikováno v:
Nature Cell Biology. 23:1255-1270
Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdc56596de458e7cb12b95625dd1327
https://doi.org/10.1038/s41556-021-00800-z
https://doi.org/10.1038/s41556-021-00800-z
Autor:
Susmita Kaushik, Yves R. Juste, Kristen Lindenau, Shuxian Dong, Adrián Macho-González, Olaya Santiago-Fernández, Mericka McCabe, Rajat Singh, Evripidis Gavathiotis, Ana Maria Cuervo
Publikováno v:
Science Advances. 8
Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation through timely expression and silencing of a vast number of genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0768dd12bb01abad70a4efb13765c3fe
https://doi.org/10.1126/sciadv.abq2733
https://doi.org/10.1126/sciadv.abq2733
Autor:
Victor Thiruthuvanathan, Susmita Kaushik, Edward Nieves, Yun Ruei Kao, Julie A. Reisz, Qian Wang, Britta Will, Ana Maria Cuervo, Angelo D'Alessandro, Shuxian Dong, Inmaculada Tasset, Evripidis Gavathiotis, Aliona Zintiridou, Monika Dzieciatkowska, Antonio Diaz
Publikováno v:
Nature
Cell Res
Cell Res
The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-long production of blood cells1. This process requires major molecular adaptations to allow HSCs to meet the regulatory and metabolic requirements for cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5344397b7aee8600e13d6ad97f1fba
http://europepmc.org/articles/PMC8428053
http://europepmc.org/articles/PMC8428053
Autor:
Julio Madrigal-Matute, Jenny de Bruijn, Kim van Kuijk, Dario F. Riascos-Bernal, Antonio Diaz, Inmaculada Tasset, Adrián Martín-Segura, Marion J. J. Gijbels, Bianca Sander, Susmita Kaushik, Erik A. L. Biessen, Simoni Tiano, Mathieu Bourdenx, Gregory J. Krause, Ian McCracken, Andrew H. Baker, Han Jin, Nicholas E. S. Sibinga, Jose Javier Bravo-Cordero, Fernando Macian, Rajat Singh, Patrick C. N. Rensen, Jimmy F. P. Berbée, Gerard Pasterkamp, Judith C. Sluimer, Ana Maria Cuervo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 119(14), e2121133119 (2022). doi:10.1073/pnas.2121133119
Proceedings of the National Academy of Sciences, 119(14). NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 119(14):2121133119. National Academy of Sciences
Madrigal-Matute, J, de Bruijn, J, van Kuijk, K, Riascos-Bernal, D F, Diaz, A, Tasset, I, Martín-Segura, A, J.J. Gijbel, M, Sander, B, Kaushik, S, Biessen, E A L, Tiano, S, Bourdenx, M, J. Krause, G, McCracken, I, Baker, A H, Han, J, Sibinga, N, Bravo-Cordero, J J, Macian, F, Singh, R, Rensen, P C N, Berbée, J F P, Pasterkamp, G, Sluimer, J & Cuervo, A M 2022, ' Protective role of chaperone-mediated autophagy against atherosclerosis ', Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.2121133119
Proceedings of the National Academy of Sciences of the United States of America, 119(14):e2121133119. National Academy of Sciences
Proceedings of the National Academy of Sciences, 119(14). NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 119(14):2121133119. National Academy of Sciences
Madrigal-Matute, J, de Bruijn, J, van Kuijk, K, Riascos-Bernal, D F, Diaz, A, Tasset, I, Martín-Segura, A, J.J. Gijbel, M, Sander, B, Kaushik, S, Biessen, E A L, Tiano, S, Bourdenx, M, J. Krause, G, McCracken, I, Baker, A H, Han, J, Sibinga, N, Bravo-Cordero, J J, Macian, F, Singh, R, Rensen, P C N, Berbée, J F P, Pasterkamp, G, Sluimer, J & Cuervo, A M 2022, ' Protective role of chaperone-mediated autophagy against atherosclerosis ', Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.2121133119
Proceedings of the National Academy of Sciences of the United States of America, 119(14):e2121133119. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America 119(14), e2121133119 (2022). doi:10.1073/pnas.2121133119
Published by National Acad. of Sciences, Washington, DC
Published by National Acad. of Sciences, Washington, DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4e87871a403362276ff3e2b09441ba
https://doi.org/10.1073/pnas.2121133119
https://doi.org/10.1073/pnas.2121133119
