Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Susie Suh"'
Autor:
Elliot H. Choi, Susie Suh, Avery E. Sears, Rafał Hołubowicz, Sanjay R. Kedhar, Andrew W. Browne, Krzysztof Palczewski
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 8, Pp 1678-1690 (2023)
Abstract Genome-editing technologies have ushered in a new era in gene therapy, providing novel therapeutic strategies for a wide range of diseases, including both genetic and nongenetic ocular diseases. These technologies offer new hope for patients
Externí odkaz:
https://doaj.org/article/d58bc19db29b4a7e9532ad192a5f1a3b
Autor:
Elliot H. Choi, Susie Suh, Andrzej T. Foik, Henri Leinonen, Gregory A. Newby, Xin D. Gao, Samagya Banskota, Thanh Hoang, Samuel W. Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C. Lyon, David R. Liu, Krzysztof Palczewski
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Leber congenital amaurosis is caused by mutations in RPE65 and leads to retinal degeneration in children. Here, the authors show that in vivo base editing can prolong the survival of cone photoreceptors and rescue their function in a mouse model of t
Externí odkaz:
https://doaj.org/article/ffc071797e4f4fa694375352a34ae7c4
Autor:
Dominik Lewandowski, Andrzej T. Foik, Roman Smidak, Elliot H. Choi, Jianye Zhang, Thanh Hoang, Aleksander Tworak, Susie Suh, Henri Leinonen, Zhiqian Dong, Antonio F.M. Pinto, Emily Tom, Jennings Luu, Joan Lee, Xiuli Ma, Erhard Bieberich, Seth Blackshaw, Alan Saghatelian, David C. Lyon, Dorota Skowronska-Krawczyk, Marcin Tabaka, Krzysztof Palczewski
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been associated with nonsyndromic and syndromic retinitis pigmentosa. Here, we show that the
Externí odkaz:
https://doaj.org/article/d6761896c71d4db8902de4c695125400
Autor:
Susie Suh, BA, Cristina Nguyen, MD, MSBS, MHA, Ludan Zhao, MD, PhD, Natasha Atanaskova Mesinkovska, MD, PhD
Publikováno v:
JAAD Case Reports, Vol 12, Iss , Pp 85-87 (2021)
Externí odkaz:
https://doaj.org/article/9d40efd56bdd4ce3a4e1bb0aa59ee10d
Autor:
Elliot H. Choi, Susie Suh, David E. Einstein, Henri Leinonen, Zhiqian Dong, Sriganesh Ramachandra Rao, Steven J. Fliesler, Seth Blackshaw, Minzhong Yu, Neal S. Peachey, Krzysztof Palczewski, Philip D. Kiser
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
The retinal pigment epithelium (RPE) provides vital metabolic support for retinal photoreceptor cells and is an important player in numerous retinal diseases. Gene manipulation in mice using the Cre-LoxP system is an invaluable tool for studying the
Externí odkaz:
https://doaj.org/article/9bd5b7f2aed546ab8d29ac38a52ecb52
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100040- (2021)
Driven by the energy of a photon, the visual pigments in rod and cone photoreceptor cells isomerize 11-cis-retinal to the all-trans configuration. This photochemical reaction initiates the signal transduction pathway that eventually leads to the tran
Externí odkaz:
https://doaj.org/article/feea638ccbf742a69e052e85fbc00721
Autor:
Robyn P Hickerson, Winston C Wey, David L Rimm, Tycho Speaker, Susie Suh, Manuel A Flores, Emilio Gonzalez-Gonzalez, Devin Leake, Christopher H Contag, Roger L Kaspar
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Despite the development of potent siRNAs that effectively target genes responsible for skin disorders, translation to the clinic has been hampered by inefficient delivery through the stratum corneum barrier and into the live cells of the epidermis. A
Externí odkaz:
https://doaj.org/article/5b246f274dc140719661a9ecf71eb076
Publikováno v:
Proceedings of the National Academy of Sciences. 119
CRISPR-Cas-based genome editing technologies could, in principle, be used to treat a wide variety of inherited diseases, including genetic disorders of vision. Programmable CRISPR-Cas nucleases are effective tools for gene disruption, but they are po
Publikováno v:
International Journal of Cosmetics and Dermatology. 1:12-20
Autor:
Akshitha Thatiparthi, Amylee Martin, Susie Suh, Katerina Yale, Natasha Atanaskova Mesinkovska
Publikováno v:
Journal of the American Academy of Dermatology. 88(1)