Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sushuang Zheng"'
Autor:
Sushila A Shenoy, Sushuang Zheng, Wencheng Liu, Yuanyi Dai, Yuanxiu Liu, Zhipeng Hou, Susumu Mori, Yi Tang, Jerry Cheng, Wenzhen Duan, Chenjian Li
Publikováno v:
eLife, Vol 11 (2022)
Here, we report the generation and characterization of a novel Huntington’s disease (HD) mouse model BAC226Q by using a bacterial artificial chromosome (BAC) system, expressing full-length human HTT with ~226 CAG-CAA repeats and containing endogeno
Externí odkaz:
https://doaj.org/article/e2bb49652e614326be44b1b058b6c3f9
Autor:
Sushuang Zheng, Sushila A Shenoy, Wencheng Liu, Yuanyi Dai, Yuanxiu Liu, Zhipeng Hou, Susumu Mori, Yi Tang, Jerry Cheng, Wenzhen Duan, Chenjian Li
Publikováno v:
eLife, Vol 11 (2022)
eLife
eLife
Here, we report the generation and characterization of a novel Huntington’s disease (HD) mouse model BAC226Q by using a bacterial artificial chromosome (BAC) system, expressing full-length human HTT with ~226 CAG-CAA repeats and containing endogeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bc9a01ab2e89d30c4e33084d3c3260
https://elifesciences.org/articles/70217
https://elifesciences.org/articles/70217
Autor:
Sushuang Zheng, Sushila A Shenoy, Wencheng Liu, Yuanyi Dai, Yuanxiu Liu, Zhipeng Hou, Susumu Mori, Yi Tang, Jerry Cheng, Wenzhen Duan, Chenjian Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d28c0c353a70e0cdd7f84b96a1a9a8a
https://doi.org/10.7554/elife.70217.sa2
https://doi.org/10.7554/elife.70217.sa2
Autor:
Shenoy, Sushila A., Sushuang Zheng, Wencheng Liu, Yuanyi Dai, Yuanxiu Liu, Zhipeng Hou, Susumu Mori, Yi Tang, Cheng, Jerry, Wenzhen Duan, Chenjian Li
Publikováno v:
eLife; 1/13/2022, p1-23, 23p
Autor:
Chenjian Li, Erin L. Seifert, Wencheng Liu, Qi Qin, Hui Zhang, Lianteng Zhi, Tanziyah Muqeem, Sushuang Zheng
Mutations and deletions in PTEN-induced kinase 1 (PINK1) cause autosomal recessive Parkinson's disease (PD), the second most common neurodegenerative disorder. PINK1 is a nuclear-genome encoded Ser/Thr kinase in mitochondria. PINK1 deletion was repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab7f3a698f43e5364b47a72ad42bfad
https://europepmc.org/articles/PMC6778692/
https://europepmc.org/articles/PMC6778692/
Publikováno v:
Journal of Genetics and Genomics. 39:261-268
The rat is a powerful model for the study of human physiology and diseases, and is preferred by physiologists, neuroscientists and toxicologists. However, the lack of robust genetic modification tools has severely limited the generation of rat geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea065dacf18cd4934db16742cf018a39
https://doi.org/10.1016/j.jgg.2012.05.003
https://doi.org/10.1016/j.jgg.2012.05.003
Publikováno v:
The Journal of Neuroscience. 29:6348-6352
B lymphocyte stimulator (BLyS), a tumor necrosis factor family protein essential for B cell development, was previously shown to be expressed at an elevated level in the CNS of multiple sclerosis patients. Although it may be involved in CNS diseases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a48caacfbc428521f3653cc6a3d500
https://doi.org/10.1523/jneurosci.5040-08.2009
https://doi.org/10.1523/jneurosci.5040-08.2009
Autor:
Renee L. Brost, Dominique Garcin, Michael Costanzo, Stéphane Hausmann, Charles Boone, Beate Schwer, Sushuang Zheng, Stewart Shuman
Publikováno v:
Journal of Biological Chemistry. 283:31706-31718
Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m7G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs. Fungi and mammalian somatic cells are able to grow in the absence of Tgs1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::637be35b99332dda7029b841f1757cb3
https://doi.org/10.1074/jbc.m806127200
https://doi.org/10.1074/jbc.m806127200
Autor:
Stewart Shuman, Sushuang Zheng
Publikováno v:
RNA. 14:2297-2304
RNA guanine-N7 methyltransferase catalyzes the third step of eukaryal mRNA capping, the transfer of a methyl group from AdoMet to GpppRNA to form m7GpppRNA. Mutational and crystallographic analyses of cellular and poxvirus cap methyltransferases have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f933d96c474e329d2aeeb816f078d8
https://doi.org/10.1261/rna.1201308
https://doi.org/10.1261/rna.1201308
Publikováno v:
Nucleic Acids Research
The S-adenosylmethionine (AdoMet) analog sinefungin is a natural product antibiotic that inhibits nucleic acid methyltransferases and arrests the growth of unicellular eukarya and eukaryal viruses. The basis for the particular sensitivity of fungi an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dacb995febeb86abe6ce863c8c7ac1
http://europepmc.org/articles/PMC2175321
http://europepmc.org/articles/PMC2175321