Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine

Autor: J. Lehmann, Sushmita Ghatak, Marta Bertolini, Jérémy Chéret, Natalia V. Botchkareva, J. Gherardini, Francisco Jimenez, Wolfgang Funk, Jeannine Wegner, Ralf Paus, Christopher M. Ward, Markus Böhm, M. Alam

Publikováno v: International Journal of Cosmetic Science
Gherardini, J, Wegner, J, Chéret, J, Ghatak, S, Lehmann, J, Alam, M, Jimenez, F, Funk, W, Böhm, M, Botchkareva, N V, Ward, C, Paus, R & Bertolini, M 2019, ' Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine ', International Journal of Cosmetic Science, vol. 41, no. 2, pp. 164-182 . https://doi.org/10.1111/ics.12521

Objectives Although the effect of ultraviolet radiation (UVR) on human skin has been extensively studied, very little is known on how UVR impacts on hair follicle (HF) homeostasis. Here, we investigated how solar spectrum UVR that hits the human skin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e093597112d3f4755518cb8b41d88cc3
http://europepmc.org/articles/PMC6850087

Role of Integrins α1β1 and α2β1 in Wound and Tumor Angiogenesis in Mice

Autor: Sushmita Ghatak, Paola Zigrino, Michael Leitges, Fang Wang, Johannes A. Eble, Beate Eckes, Cornelia Mauch, Jan-Niklas Schulz, Stephan Niland, Thomas Krieg

Publikováno v: The American Journal of Pathology. 186:3011-3027

Integrins are transmembrane receptors composed of one α subunit and one β subunit and are involved in cellular growth, differentiation, and apoptosis. The collagen-binding integrins α1β1 and α2β1 have been shown to regulate wound and tumor vasc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa143f4a599cf7a2b985922709571df
https://doi.org/10.1016/j.ajpath.2016.06.021

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

Autor: Frederik Tellkamp, Christian Günschmann, Sara A. Wickström, Sushmita Ghatak, Assa Yeroslaviz, Ana Pombo, Christoph Dieterich, Huy Quang Le, Carien M. Niessen, Ching-Yan Chloé Yeung, Bianca Habermann

Publikováno v: Nature Cell Biology
Nat Cell Biol

Tissue mechanics drive morphogenesis, but how forces are sensed and transmitted to control stem cell fate and self-organization remains unclear. We show that a mechanosensory complex of emerin (Emd), non-muscle myosin IIA (NMIIA) and actin controls g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1372713df7849ae8f16f14f2a67acd4b
https://pubmed.ncbi.nlm.nih.gov/27398909

Integrin-linked kinase regulates the niche of quiescent epidermal stem cells

Autor: Sushmita Ghatak, Sara A. Wickström, Christoph Dieterich, Jessica Morgner, Monique Aumailley, Tobias Jakobi

Publikováno v: Nat Commun
Nature Communications

Stem cells reside in specialized niches that are critical for their function. Quiescent hair follicle stem cells (HFSCs) are confined within the bulge niche, but how the molecular composition of the niche regulates stem cell behaviour is poorly under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833b93fefdac49198475559ff4473e88
https://hdl.handle.net/21.11116/0000-000B-7ACB-8

552 Combined loss of integrins α1β1 and α2β1 results in reduced angiogenesis in mice

Autor: Sushmita Ghatak, Paola Zigrino, Jan-Niklas Schulz, Cornelia Mauch, Stephan Niland, Beate Eckes, Fang Wang, Thomas Krieg

Publikováno v: Journal of Investigative Dermatology. 136:S255

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e01fc5f025c7af029940d820ac8d99d
https://doi.org/10.1016/j.jid.2016.06.576