Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sushma, Bharrhan"'
Autor:
Nicholas J. First, Katelyn M. Parrish, Amparo Martínez-Pérez, África González-Fernández, Sushma Bharrhan, Matthew Woolard, James B. McLachlan, Rona S. Scott, Jian Wang, Monica C. Gestal
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113294- (2023)
Summary: Bordetella spp. are respiratory pathogens equipped with immune evasion mechanisms. We previously characterized a Bordetella bronchiseptica mutant (RB50ΔbtrS) that fails to suppress host responses, leading to rapid clearance and long-lasting
Externí odkaz:
https://doaj.org/article/1873108fec1342a0bbb5576abc0ed691
Autor:
Yong Chen, Sushma Bharrhan, Jiayong Xu, Tarina Sharma, Yanhua Wang, Padmini Salgame, Jinghang Zhang, Kievershen Nargan, Adrie J C Steyn, Paul J Maglione, John Chan
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011187 (2023)
The current study reveals that in chronic TB, the B cell-deficient μMT strain, relative to wild-type (WT) C57BL/6 mice, displays in the lungs lower levels of inflammation that are associated with decreased CD4+ T cell proliferation, diminished Th1 r
Externí odkaz:
https://doaj.org/article/1e9c63ac92844481ad775dcb873ccf70
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20635 (2011)
Induction of nuclear factor kappa B (NF-κB)-mediated gene expression has been implicated in the pathogenesis of alcoholic liver disease through enhanced production of reactive oxygen species and pro-inflammatory mediators. The present study was carr
Externí odkaz:
https://doaj.org/article/cc85ade3ea5745329f7f645c1ed9e6e2
Autor:
Jiayong Xu, Scott J. Garforth, Steven A. Porcelli, Cecilia S. Lindestam Arlehamn, Steven C. Almo, William R. Jacobs, Steven C. Kennedy, Alessandro Sette, Sushma Bharrhan, John Chan, Alison J. Johnson
Publikováno v:
Infection and Immunity. 86
Mycobacterium tuberculosis remains a threat to global health, and a more efficacious vaccine is needed to prevent disease caused by M. tuberculosis We previously reported that the mycobacterial ribosome is a major target of CD4+ T cells in mice immun
Autor:
Rohit K. Jangra, Pablo Guardado-Calvo, Rong Li, Elisabeth K. Nyakatura, Sushma Bharrhan, Melinda Ng, Ana I. Kuehne, Andrew S. Herbert, Lucas T. Jae, James Pan, Sarah L. Barker, Eva Mittler, John M. Dye, Lara M. Kleinfelter, Anna Z. Wec, Jonathan R. Lai, Ariel S. Wirchnianski, Sachdev S. Sidhu, Félix A. Rey, Nicolas A. Muena, Megan M. Slough, Jason Moffat, Kartik Chandran, M. Eugenia Dieterle, J. Maximilian Fels, Thijn R. Brummelkamp, Nicole D. Tischler, Gleyder Roman-Sosa, Zhongde Wang
Publikováno v:
Nature
Nature, Nature Publishing Group, 2018, 563 (7732), pp.559-563. ⟨10.1038/s41586-018-0702-1⟩
Nature, 2018, 563 (7732), pp.559-563. ⟨10.1038/s41586-018-0702-1⟩
Nature, Nature Publishing Group, 2018, 563 (7732), pp.559-563. ⟨10.1038/s41586-018-0702-1⟩
Nature, 2018, 563 (7732), pp.559-563. ⟨10.1038/s41586-018-0702-1⟩
The zoonotic transmission of hantaviruses from their rodent hosts to humans in North and South America is associated with a severe and frequently fatal respiratory disease, hantavirus pulmonary syndrome (HPS)1,2. No specific antiviral treatments for
Autor:
Steven C, Kennedy, Alison J, Johnson, Sushma, Bharrhan, Cecilia S, Lindestam Arlehamn, Jiayong, Xu, Scott J, Garforth, John, Chan, William R, Jacobs, Alessandro, Sette, Steven C, Almo, Steven A, Porcelli
Publikováno v:
Infection and immunity. 86(9)
Mycobacterium tuberculosis remains a threat to global health, and a more efficacious vaccine is needed to prevent disease caused by M. tuberculosis. We previously reported that the mycobacterial ribosome is a major target of CD4(+) T cells in mice im
Autor:
Yong Chen, JoAnne L. Flynn, Arturo Casadevall, John Chan, Simren Mehta, Sushma Bharrhan, Jacqueline M. Achkar
Publikováno v:
Seminars in Immunology. 26:588-600
Mycobacterium tuberculosis remains a major public health burden. It is generally thought that while B cell- and antibody-mediated immunity plays an important role in host defense against extracellular pathogens, the primary control of intracellular m
Publikováno v:
Journal of Gastrointestinal Infections. 3:33-40
Autor:
John R. Christin, M. Javad Aman, Sushma Bharrhan, Sergey Shulenin, Jonathan R. Lai, Ana I. Kuehne, Andrew S. Herbert, Katie A. Howell, Erica Ollmann Saphire, Elisabeth K. Nyakatura, John M. Dye, James E. Crowe, Anna Z. Wec, Kartik Chandran, Frederick W. Holtsberg, Andrew I. Flyak, Zachary A. Bornholdt, Rohit K. Jangra, Russell R. Bakken, Eva Mittler
There is an urgent need for monoclonal antibody (mAb) therapies that broadly protect against Ebola virus and other filoviruses. The conserved, essential interaction between the filovirus glycoprotein, GP, and its entry receptor Niemann-Pick C1 (NPC1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14bad6d35a910d68231cd3b891d7846
https://europepmc.org/articles/PMC5647781/
https://europepmc.org/articles/PMC5647781/
Publikováno v:
American Journal of Biomedical Sciences. :51-62
Vitamin E (-Tocopherol [-Toc]) is the primary membrane bound, lipid-soluble, chain-breaking antioxidant that has been reported to protect against lipid peroxidation-induced tissue damage. Therefore, the present study was designed to investigate