Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Susheel K. Singh"'
Autor:
Kwadwo A. Kusi, Linda E. Amoah, Festus Kojo Acquah, Nana Aba Ennuson, Abena F. Frempong, Ebenezer A. Ofori, Kwadwo Akyea-Mensah, Eric Kyei-Baafour, Frank Osei, Augustina Frimpong, Susheel K. Singh, Michael Theisen, Edmond J. Remarque, Bart W. Faber, Maria Belmonte, Harini Ganeshan, Jun Huang, Eileen Villasante, Martha Sedegah
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionDiversity in malarial antigens is an immune evasion mechanism that gives malaria parasites an edge over the host. Immune responses against one variant of a polymorphic antigen are usually not fully effective against other variants due to
Externí odkaz:
https://doaj.org/article/3f269e03fb724254ab158d53d636aa78
Autor:
Isabel Byrne, Timothy William, Tock H. Chua, Catriona Patterson, Tom Hall, Mark Tan, Chetan Chitnis, John Adams, Susheel K. Singh, Lynn Grignard, Kevin K. A. Tetteh, Kimberly M. Fornace, Chris J. Drakeley
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Malaysia has reported no indigenous cases of P. falciparum and P. vivax for over 3 years. When transmission reaches such low levels, it is important to understand the individuals and locations where exposure risks are high, as they may be at
Externí odkaz:
https://doaj.org/article/a7bfd19017534ba6b1692f317f514ff5
Autor:
Eric Kyei-Baafour, Kwadwo Asamoah Kusi, Fareed K.N. Arthur, Regis W. Tiendrebeogo, Eunice Owusu-Yeboa, Susheel K. Singh, Sarah Friedrich, Thomas A. Gerds, Daniel Dodoo, Michael Theisen, Bright Adu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundNaturally acquired immunity to malaria may involve different immune mechanisms working in concert, however, their respective contributions and potential antigenic targets have not been clearly established. Here, we assessed the roles of ops
Externí odkaz:
https://doaj.org/article/9144346ef0034022b78295fd3c93ef9a
Autor:
Susheel K. Singh, Jordan Plieskatt, Bishwanath K. Chourasia, Vandana Singh, Karin Lövgren Bengtsson, Jenny M. Reimer, Renate C. van Daalen, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Matthijs M. Jore, Michael Theisen
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract The Plasmodium falciparum Pfs230 and Pfs48/45 proteins are leading candidates for a malaria transmission-blocking vaccine (TBV). Previously, we showed that a Pfs230–Pfs48/45 fusion protein elicits higher levels of functional antibodies tha
Externí odkaz:
https://doaj.org/article/d23619f475cb4d5dbe3391e5cc32c116
Autor:
Sylvester Dassah, Bright Adu, Régis W. Tiendrebeogo, Susheel K. Singh, Fareed K. N. Arthur, Sodiomon B. Sirima, Michael Theisen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
GMZ2 is a malaria vaccine candidate evaluated in a phase 2b multi-centre trial. Here we assessed antibody responses and the association of naturally acquired immunity with incidence of malaria in one of the trial sites, Banfora in Burkina Faso. The a
Externí odkaz:
https://doaj.org/article/a4c08a2ebb4847969416712e18bc0b4f
Autor:
Roos M. de Jong, Susheel K. Singh, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Will J. R. Stone, Emily Locke, Jordan Plieskatt, Michael Theisen, Teun Bousema, Matthijs M. Jore
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Malaria transmission blocking vaccines (TBV) aim to induce antibodies that can interrupt Plasmodium falciparum development in the mosquito midgut and thereby prevent onward malaria transmission. A limited number of TBV candidates have been identified
Externí odkaz:
https://doaj.org/article/5eb064a5bbc444078aa8aae5c7b6d44b
Autor:
Cyrielle Fougeroux, Louise Goksøyr, Manja Idorn, Vladislav Soroka, Sebenzile K. Myeni, Robert Dagil, Christoph M. Janitzek, Max Søgaard, Kara-Lee Aves, Emma W. Horsted, Sayit Mahmut Erdoğan, Tobias Gustavsson, Jerzy Dorosz, Stine Clemmensen, Laurits Fredsgaard, Susan Thrane, Elena E. Vidal-Calvo, Paul Khalifé, Thomas M. Hulen, Swati Choudhary, Michael Theisen, Susheel K. Singh, Asier Garcia-Senosiain, Linda Van Oosten, Gorben Pijlman, Bettina Hierzberger, Tanja Domeyer, Blanka W. Nalewajek, Anette Strøbæk, Magdalena Skrzypczak, Laura F. Andersson, Søren Buus, Anette Stryhn Buus, Jan Pravsgaard Christensen, Tim J. Dalebout, Kasper Iversen, Lene H. Harritshøj, Benjamin Mordmüller, Henrik Ullum, Line S. Reinert, Willem Adriaan de Jongh, Marjolein Kikkert, Søren R. Paludan, Thor G. Theander, Morten A. Nielsen, Ali Salanti, Adam F. Sander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Here the authors generate a capsid-like particle based vaccine candidate displaying the receptor-binding domain of the SARS-CoV-2 spike protein and show induction of neutralizing antibodies after intramuscular prime-boost immunization in mice.
Externí odkaz:
https://doaj.org/article/c047e4469bfc4df49317bf7ddb5a7a95
Autor:
Lindsey Wu, Julia Mwesigwa, Muna Affara, Mamadou Bah, Simon Correa, Tom Hall, Susheel K. Singh, James G. Beeson, Kevin K. A. Tetteh, Immo Kleinschmidt, Umberto D’Alessandro, Chris Drakeley
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background As The Gambia aims to achieve malaria elimination by 2030, serological assays are a useful surveillance tool to monitor trends in malaria incidence and evaluate community-based interventions. Methods Within a mass drug administrat
Externí odkaz:
https://doaj.org/article/ce56f92ce0cc4478bcddfe3fba1715fd
Autor:
Lindsey Wu, Julia Mwesigwa, Muna Affara, Mamadou Bah, Simon Correa, Tom Hall, Susheel K. Singh, James G. Beeson, Kevin K. A. Tetteh, Immo Kleinschmidt, Umberto D’Alessandro, Chris Drakeley
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background As malaria transmission declines, sensitive diagnostics are needed to evaluate interventions and monitor transmission. Serological assays measuring malaria antibody responses offer a cost-effective detection method to supplement e
Externí odkaz:
https://doaj.org/article/c6467302c2384b85a6ab50914c04e6af
Autor:
Susheel K. Singh, Jordan Plieskatt, Bishwanath K. Chourasia, Amanda Fabra-García, Asier Garcia-Senosiain, Vandana Singh, Karin Lövgren Bengtsson, Jenny M. Reimer, Robert Sauerwein, Matthijs M. Jore, Michael Theisen
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
The cysteine-rich Pfs48/45 protein, a Plasmodium falciparum sexual stage surface protein, has been advancing as a candidate antigen for a transmission-blocking vaccine (TBV) for malaria. However, Pfs48/45 contains multiple disulfide bonds, that are c
Externí odkaz:
https://doaj.org/article/abac308fce534339b9649af5cb94636e