Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sushant Malhotra"'
Autor:
Fabienne Hoffmann-Emery, Katrin Niedermann, Pankaj D. Rege, Manuel Konrath, Christian Lautz, Anne Katrin Kraft, Carine Steiner, Fritz Bliss, André Hell, Rolf Fischer, Diane E. Carrera, Danial Beaudry, Remy Angelaud, Sushant Malhotra, Francis Gosselin
Publikováno v:
Organic Process Research & Development. 26:313-322
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74f7834f718bfaf54b7f9dfb9dca881e
https://doi.org/10.1021/acs.oprd.1c00389
https://doi.org/10.1021/acs.oprd.1c00389
Autor:
Bryan K. Chan, Eileen Seward, Michael Lainchbury, Thomas F. Brewer, Le An, Toby Blench, Matthew W. Cartwright, Grace Ka Yan Chan, Edna F. Choo, Jason Drummond, Richard L. Elliott, Emanuela Gancia, Lewis Gazzard, Baihua Hu, Graham E. Jones, Xifeng Luo, Andrew Madin, Sushant Malhotra, John G. Moffat, Jodie Pang, Laurent Salphati, Christopher J. Sneeringer, Craig E. Stivala, Binqing Wei, Weiru Wang, Ping Wu, Timothy P. Heffron
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hematopoietic progenitor kinase 1 (HPK1) is implicated as a negative regulator of T-cell receptor-induced T-cell activation. Studies using HPK1 kinase-dead knock-in animals have demonstrated the loss of HPK1 kinase activity resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11f71008647153e48985266e826374
https://doi.org/10.1021/acsmedchemlett.1c00473
https://doi.org/10.1021/acsmedchemlett.1c00473
Autor:
Francis Gosselin, Jie Xu, Rémy Angelaud, Brandon Scott, Lauren E. Sirois, Sushant Malhotra, David Lao, Paroma Chakravarty, Jerry Tso
Publikováno v:
Organic Process Research & Development. 24:567-578
Process development for a multi-kilogram-scale synthesis of GDC-0022, an inhibitor of retinoic acid receptor-related orphan receptor γ (RORc), is described. Delivery of the active pharmaceutical in...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5df251b99338359e0be35ade9db94b4
https://doi.org/10.1021/acs.oprd.0c00012
https://doi.org/10.1021/acs.oprd.0c00012
Autor:
Marie Evangelista, Siyu Feng, Yang Xiao, James T. Koerber, Sushant Malhotra, Mark Merchant, Vidhyalakshmi Arumugam, Yvonne Franke, Cheng Lu, Joachim Rudolph, Christopher W. Davies, Rana Mroue, Angela Oh, Emily Chan, Sangeeta Jayakar, Melinda Mulvihil, Hans E. Purkey, John G. Quinn, Weiru Wang, Hartmut Koeppen
The discovery of covalent inhibitors binding the switch II (SWII) pocket has enabled therapeutic intervention in KRASG12C driven tumors and represents a milestone in targeting KRAS-driven cancers. However, the transient nature and high energetic barr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d446bf3d3aed775f1d51e08933a1dc
https://doi.org/10.21203/rs.3.rs-133893/v1
https://doi.org/10.21203/rs.3.rs-133893/v1
Autor:
David Linder, Francis Gosselin, Philippe James, Remy Angelaud, Ngiap-Kie Lim, Danial Beaudry, Theresa Cravillion, Haiming Zhang, Jessica L. Defreese, Sushant Malhotra, Chong Han, Qingping Tian, Alec Fettes
Publikováno v:
Organic Process Research & Development. 22:978-990
Efforts toward the process development of reversible Bruton’s tyrosine kinase (BTK) inhibitor GDC-0853 (1) are described. A practical synthesis of GDC-0853 was accomplished via a key highly regioselective Pd-catalyzed C–N coupling of tricyclic la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e2b771a677f914a3b28c27d233a43d
https://doi.org/10.1021/acs.oprd.8b00134
https://doi.org/10.1021/acs.oprd.8b00134
Publikováno v:
European Journal of Neuroscience. 42:2818-2832
The human and rodent ventral striatal local field potentials show striking oscillations in the gamma band (~ 40-100 Hz), which have been linked to aspects of behaviour such as reward anticipation and delivery, movement initiation, learning from feedb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23943f941a63c21d2d8df6e851c5c08
https://doi.org/10.1111/ejn.13069
https://doi.org/10.1111/ejn.13069
Publikováno v:
Chemistry - A European Journal. 21:1961-1965
Chromium(II) chloride catalyzes the chemoselective cross-coupling reaction of dichloropyridines with a range of functionalized (hetero)aromatic Grignard reagents at room temperature. Functional groups, such as esters and acetals, are well tolerated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c96e402ae6e1c136c893c3c6a7d451
https://doi.org/10.1002/chem.201405275
https://doi.org/10.1002/chem.201405275
Publikováno v:
Organic Letters. 16:3468-3471
Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681881c5bb1cd7d2ca900dc9b35065d5
https://doi.org/10.1021/ol501389k
https://doi.org/10.1021/ol501389k
Autor:
Barry M. Trost, Sushant Malhotra
Publikováno v:
Chemistry - A European Journal. 20:8288-8292
A concise asymmetric synthesis of aminocyclitols such as diastereomeric 2-deoxystreptamine analogues and conduramine A is described. The Pd-catalyzed asymmetric desymmetrization of meso 1,4-dibenzolate enables the synthesis of highly oxidized cycloha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5675db93610b0df503cfd635128eb171
https://doi.org/10.1002/chem.201402175
https://doi.org/10.1002/chem.201402175
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 37:1985-1998
Pinacol esters of boronic acids are widely used as starting materials in organic synthesis for Suzuki-Miyaura chemistry. The accurate analysis of these esters is complicated by competing hydrolysis to the corresponding boronic acids under typical RP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3a39589c952009f3bd229e46e224001
https://doi.org/10.1080/10826076.2013.825856
https://doi.org/10.1080/10826076.2013.825856