Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sushant Malhotra"'
Autor:
Fabienne Hoffmann-Emery, Katrin Niedermann, Pankaj D. Rege, Manuel Konrath, Christian Lautz, Anne Katrin Kraft, Carine Steiner, Fritz Bliss, André Hell, Rolf Fischer, Diane E. Carrera, Danial Beaudry, Remy Angelaud, Sushant Malhotra, Francis Gosselin
Publikováno v:
Organic Process Research & Development. 26:313-322
Autor:
Christopher W. Davies, Angela J. Oh, Rana Mroue, Micah Steffek, John M. Bruning, Yang Xiao, Siyu Feng, Sangeeta Jayakar, Emily Chan, Vidhyalakshmi Arumugam, Sean Carlo Uribe, Jake Drummond, Alexandra Frommlet, Cheng Lu, Yvonne Franke, Mark Merchant, Hartmut Koeppen, John G. Quinn, Sushant Malhotra, Steve Do, Lewis Gazzard, Hans E. Purkey, Joachim Rudolph, Melinda M. Mulvihill, James T. Koerber, Weiru Wang, Marie Evangelista
Publikováno v:
Nature Biotechnology. 40:769-778
Small molecules that stabilize inactive protein conformations are an underutilized strategy for drugging dynamic or otherwise intractable proteins. To facilitate the discovery and characterization of such inhibitors, we created a screening platform t
Autor:
Bryan K. Chan, Eileen Seward, Michael Lainchbury, Thomas F. Brewer, Le An, Toby Blench, Matthew W. Cartwright, Grace Ka Yan Chan, Edna F. Choo, Jason Drummond, Richard L. Elliott, Emanuela Gancia, Lewis Gazzard, Baihua Hu, Graham E. Jones, Xifeng Luo, Andrew Madin, Sushant Malhotra, John G. Moffat, Jodie Pang, Laurent Salphati, Christopher J. Sneeringer, Craig E. Stivala, Binqing Wei, Weiru Wang, Ping Wu, Timothy P. Heffron
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hematopoietic progenitor kinase 1 (HPK1) is implicated as a negative regulator of T-cell receptor-induced T-cell activation. Studies using HPK1 kinase-dead knock-in animals have demonstrated the loss of HPK1 kinase activity resulted
Autor:
Francis Gosselin, Jie Xu, Rémy Angelaud, Brandon Scott, Lauren E. Sirois, Sushant Malhotra, David Lao, Paroma Chakravarty, Jerry Tso
Publikováno v:
Organic Process Research & Development. 24:567-578
Process development for a multi-kilogram-scale synthesis of GDC-0022, an inhibitor of retinoic acid receptor-related orphan receptor γ (RORc), is described. Delivery of the active pharmaceutical in...
Autor:
Marie Evangelista, Siyu Feng, Yang Xiao, James T. Koerber, Sushant Malhotra, Mark Merchant, Vidhyalakshmi Arumugam, Yvonne Franke, Cheng Lu, Joachim Rudolph, Christopher W. Davies, Rana Mroue, Angela Oh, Emily Chan, Sangeeta Jayakar, Melinda Mulvihil, Hans E. Purkey, John G. Quinn, Weiru Wang, Hartmut Koeppen
The discovery of covalent inhibitors binding the switch II (SWII) pocket has enabled therapeutic intervention in KRASG12C driven tumors and represents a milestone in targeting KRAS-driven cancers. However, the transient nature and high energetic barr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d446bf3d3aed775f1d51e08933a1dc
https://doi.org/10.21203/rs.3.rs-133893/v1
https://doi.org/10.21203/rs.3.rs-133893/v1
Autor:
David Linder, Francis Gosselin, Philippe James, Remy Angelaud, Ngiap-Kie Lim, Danial Beaudry, Theresa Cravillion, Haiming Zhang, Jessica L. Defreese, Sushant Malhotra, Chong Han, Qingping Tian, Alec Fettes
Publikováno v:
Organic Process Research & Development. 22:978-990
Efforts toward the process development of reversible Bruton’s tyrosine kinase (BTK) inhibitor GDC-0853 (1) are described. A practical synthesis of GDC-0853 was accomplished via a key highly regioselective Pd-catalyzed C–N coupling of tricyclic la
Publikováno v:
European Journal of Neuroscience. 42:2818-2832
The human and rodent ventral striatal local field potentials show striking oscillations in the gamma band (~ 40-100 Hz), which have been linked to aspects of behaviour such as reward anticipation and delivery, movement initiation, learning from feedb
Publikováno v:
Chemistry - A European Journal. 21:1961-1965
Chromium(II) chloride catalyzes the chemoselective cross-coupling reaction of dichloropyridines with a range of functionalized (hetero)aromatic Grignard reagents at room temperature. Functional groups, such as esters and acetals, are well tolerated i
Publikováno v:
Organic Letters. 16:3468-3471
Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynami
Autor:
Barry M. Trost, Sushant Malhotra
Publikováno v:
Chemistry - A European Journal. 20:8288-8292
A concise asymmetric synthesis of aminocyclitols such as diastereomeric 2-deoxystreptamine analogues and conduramine A is described. The Pd-catalyzed asymmetric desymmetrization of meso 1,4-dibenzolate enables the synthesis of highly oxidized cycloha