Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sushant Bhatnagar"'
Autor:
Mark P. Keller, Kelly L. Hudkins, Anath Shalev, Sushant Bhatnagar, Melkam A. Kebede, Matthew J. Merrins, Dawn Belt Davis, Charles E. Alpers, Michelle E. Kimple, Alan D. Attie
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107036- (2023)
Summary: Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we sere
Externí odkaz:
https://doaj.org/article/2a0d513bf5f14082a8f6d638bd1a6e49
Autor:
Haifa Alsharif, Mary N. Latimer, Katherine C. Perez, Justin Alexander, Md Mostafizur Rahman, Anil K. Challa, Jeong-A. Kim, Sasanka Ramanadham, Martin Young, Sushant Bhatnagar
Publikováno v:
Metabolites, Vol 13, Iss 6, p 711 (2023)
Effective energy expenditure is critical for maintaining body weight (BW). However, underlying mechanisms contributing to increased BW remain unknown. We characterized the role of brain angiogenesis inhibitor-3 (BAI3/ADGRB3), an adhesion G-protein co
Externí odkaz:
https://doaj.org/article/6db45d1f199a4eb3b7390d521cd46ac2
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 12, Pp 2647-2663 (2007)
The therapeutic utility of liver X receptor (LXR) agonists in treating atherosclerosis is limited by an undesired accumulation of triglycerides in the blood and liver. This effect is caused by an increase in the transcription of genes involved in fat
Externí odkaz:
https://doaj.org/article/b6210827f061420aaedd61a71995716b
Autor:
Sushant Bhatnagar, Angie T Oler, Mary E Rabaglia, Donald S Stapleton, Kathryn L Schueler, Nathan A Truchan, Sara L Worzella, Jonathan P Stoehr, Susanne M Clee, Brian S Yandell, Mark P Keller, Debbie C Thurmond, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002323 (2011)
We previously mapped a type 2 diabetes (T2D) locus on chromosome 16 (Chr 16) in an F2 intercross from the BTBR T (+) tf (BTBR) Lep(ob/ob) and C57BL/6 (B6) Lep(ob/ob) mouse strains. Introgression of BTBR Chr 16 into B6 mice resulted in a consomic mous
Externí odkaz:
https://doaj.org/article/f5f6a4e093c04a5b93c5c3211496fac1
Autor:
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-a Kim
Publikováno v:
ACS Appl Mater Interfaces
Nitric oxide (NO) is a gaseous signaling molecule, which plays crucial roles in various biological processes, including inflammatory responses, metabolism, cardiovascular functions, and cognitive function. NO bioavailability is reduced with aging and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fe4377454e1d92ec9f7ed20d2b06d6
https://doi.org/10.1021/acsami.1c24113
https://doi.org/10.1021/acsami.1c24113
Autor:
Md Mostafizur Rahman, Asmita Pathak, Kathryn L Schueler, Haifa Al Sharif, Ava Michl, Justin Alexander, Jeonga-a Kim, Edwin Chapman, Sushant Bhatnagar
SummaryStimulus-coupled insulin secretion from β-cells involves the fusion of insulin granules to the plasma membrane (PM) via SNARE complex formation—a cellular process key for maintaining whole-body glucose homeostasis. Optimal insulin secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9ecf463a072d290a34426079b39215
https://doi.org/10.1101/2022.10.20.513128
https://doi.org/10.1101/2022.10.20.513128
Publikováno v:
Journal of Pharmaceutical Research International. :237-244
This study was conducted to evaluate the influence and cooperation of Orthodontic patients to wear removable retainer by sending reminder text messages. 54 orthodontic patients (24 males and 30 females) aged between 18 to 25 year were enrolled for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::235932f79cbb5da03f0e8b7261b19de9
https://doi.org/10.9734/jpri/2021/v33i38a32080
https://doi.org/10.9734/jpri/2021/v33i38a32080
Publikováno v:
Diabetes. 71
Insulin secretion from pancreatic β-cells occurs in a biphasic manner. The loss of insulin secretion, entailing the inability of insulin granules to fuse with the plasma membrane (PM) via the formation of the SNARE complex, is a key determinant in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8d2c67cf03978ec5e97dd7a7579bba
https://doi.org/10.2337/db22-314-or
https://doi.org/10.2337/db22-314-or
Publikováno v:
Diabetes. 71
Previously, we identified complement-1q like-3 (C1ql3) secreted protein as a hub gene affecting pancreatic islet function in obese mice using network biology. We demonstrated that the recombinant C1ql3 protein inhibits insulin secretion stimulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a61ca4a22569f64975b813fce8c250a
https://doi.org/10.2337/db22-1455-p
https://doi.org/10.2337/db22-1455-p
Autor:
Jeong-a Kim, Qinglin Yang, Sushant Bhatnagar, Hae-Suk Kim, Teayoun Kim, Young Yil Bahk, Guang Ren
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Autophagy, an integral part of the waste recycling process, plays an important role in cellular physiology and pathophysiology. Impaired autophagic flux causes ectopic lipid deposition, which is defined as the accumulation of lipids in non-adipose ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a30001144a72df8149bb2172161ee3d
http://link.springer.com/article/10.1038/s41598-020-70347-w
http://link.springer.com/article/10.1038/s41598-020-70347-w