ELM—the eukaryotic linear motif resource in 2020

Autor: Jesús Alvarado Valverde, Juliana Glavina, Jelena Čalyševa, Dayana Bukirova, Toby J. Gibson, Hugo Sámano-Sánchez, Nicolas Palopoli, Norman E. Davey, Marc Gouw, Manjeet Kumar, Athina Diakogianni, Rita Pancsa, Lucía B. Chemes, Sushama Michael

Publikováno v: Nucleic Acids Research
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource for the molecular biology com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcaf1973897ef615bf90bf57cd91dfff
http://europepmc.org/articles/PMC7145657

How to Annotate and Submit a Short Linear Motif to the Eukaryotic Linear Motif Resource

Autor: Kim Van Roey, Jesús Alvarado-Valverde, Manjeet Kumar, Marc Gouw, Francesca Diella, Sushama Michael, Jelena Čalyševa, Holger Dinkel, Toby J. Gibson

Publikováno v: Intrinsically Disordered Proteins: Methods and Protocols
Methods in Molecular Biology
Methods in Molecular Biology-Intrinsically Disordered Proteins
Intrinsically Disordered Proteins-Methods and Protocols
Methods in Molecular Biology ISBN: 9781071605233

Over the past few years, it has become apparent that approximately 35% of the human proteome consists of intrinsically disordered regions. Many of these disordered regions are rich in short linear motifs (SLiMs) which mediate protein-protein interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d095e243ef4b9689ee51a2c04e603ded
https://hdl.handle.net/21.11116/0000-0006-C2E3-E

Discovery of candidate KEN-box motifs using Cell Cycle keyword enrichment combined with native disorder prediction and motif conservation

Autor: Gilles Travé, Claudia Chica, Toby J. Gibson, Sushama Michael, Chenna Ramu

Publikováno v: Bioinformatics
Bioinformatics, Oxford University Press (OUP), 2008, 24 (4), pp.453-457. ⟨10.1093/bioinformatics/btm624⟩

Motivation: KEN-box-mediated target selection is one of the mechanisms used in the proteasomal destruction of mitotic cell cycle proteins via the APC/C complex. While annotating the Eukaryotic Linear Motif resource (ELM, http://elm.eu.org/), we found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2d41c07d456ac5c1dcfe3cf9fe4156
https://doi.org/10.1093/bioinformatics/btm624

ELM: the status of the 2010 eukaryotic linear motif resource

Autor: Aidan Budd, Markus Seiler, Leszek Rychlewski, Rune Linding, Robert J. Weatheritt, Sophie Chabanis-Davidson, Norman E. Davey, Timothy P. Hughes, Sushama Michael, Ahmed Sayadi, Francesca Diella, Pål Puntervoll, Cathryn M. Gould, Jakub Pas, Allegra Via, Manuela Helmer-Citterich, Claudia Chica, Neill Haslam, Jan Christian Bryne, Christine Gemünd, Rein Aasland, Toby J. Gibson, Gilles Travé

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2010, 38 (suppl_1), pp.D167-D180. ⟨10.1093/nar/gkp1016⟩

Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. Many thousands of linear m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30288c6e97825b7aa91b367dc0d4f3c
https://hdl.handle.net/1956/12072

Discovery of candidate KEN-box motifs using Cell Cycle keyword enrichment combined with native disorder prediction and motif conservation.

Autor: Sushama Michael, Gilles Travé, Chenna Ramu, Claudia Chica, Toby J. Gibson

Publikováno v: Bioinformatics; Feb2008, Vol. 24 Issue 4, p453-453, 1p