Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Susanne von Gronau"'
Autor:
J. Josephine Botsch, Roswitha Junker, Michèle Sorgenfrei, Patricia P. Ogger, Luca Stier, Susanne von Gronau, Peter J. Murray, Markus A. Seeger, Brenda A. Schulman, Bastian Bräuning
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Transmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, and metabolic regulation, are determined by ER-resident MARCH6 E3 ligases, including Doa10 in yeast. Here, we present Doa10/MARCH6 struct
Externí odkaz:
https://doaj.org/article/83b8992d9946492ea98c04163ae4e8c3
Autor:
Iona Wallace, Kheewoong Baek, J. Rajan Prabu, Ronnald Vollrath, Susanne von Gronau, Brenda A. Schulman, Kirby N. Swatek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The attachment of the ubiquitin-like protein ISG15 to substrates by specific E1-E2-E3 enzymes is a well-established signalling mechanism of the innate immune response. Here, we present a 3.45 Å cryo-EM structure of a chemically trapped UBE1
Externí odkaz:
https://doaj.org/article/6263318ce67744db9c3234db9bdea50d
Autor:
Shuai Qiao, Chia-Wei Lee, Dawafuti Sherpa, Jakub Chrustowicz, Jingdong Cheng, Maximilian Duennebacke, Barbara Steigenberger, Ozge Karayel, Duc Tung Vu, Susanne von Gronau, Matthias Mann, Florian Wilfling, Brenda A. Schulman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The GID E3 ligase regulates glucose-induced degradation in yeast, and key physiology. This study unveils E3 ligase regulation by reshaping the substrate binding site, blocking substrate access to ubiquitination active sites, and a Cage-like assembly.
Externí odkaz:
https://doaj.org/article/c583585898434b8aa4aef128b19aceb1
Autor:
Linus V M, Hopf, Kheewoong, Baek, Maren, Klügel, Susanne, von Gronau, Yue, Xiong, Brenda A, Schulman
Publikováno v:
Nature structuralmolecular biology. 29(9)
Most cullin-RING ubiquitin ligases (CRLs) form homologous assemblies between a neddylated cullin-RING catalytic module and a variable substrate-binding receptor (for example, an F-box protein). However, the vertebrate-specific CRL7
Autor:
Daniel Horn-Ghetko, Arno F. Alpi, Brenda A. Schulman, Susanne von Gronau, Sebastian Kostrhon, Maren Klügel, Kheewoong Baek, Jérôme Basquin, J. Rajan Prabu
Publikováno v:
Nature Chemical Biology
An emerging mechanism of ubiquitylation involves partnering of two distinct E3 ligases. In the best-characterized E3-E3 pathways, ARIH-family RING-between-RING (RBR) E3s ligate ubiquitin to substrates of neddylated cullin-RING E3s. The E3 ARIH2 has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b3508670e1a3f562bf4065c7458d63
https://hdl.handle.net/21.11116/0000-0009-C298-021.11116/0000-0009-C29A-E
https://hdl.handle.net/21.11116/0000-0009-C298-021.11116/0000-0009-C29A-E
Autor:
David T. Krist, Kheewoong Baek, Gary Kleiger, Lisa-Marie Neumaier, Maren Klügel, J. Rajan Prabu, Susanne von Gronau, Spencer Hill, Brenda A. Schulman
Publikováno v:
Nature
Eukaryotic cell biology depends on cullin-RING E3 ligase (CRL)-catalysed protein ubiquitylation(1), which is tightly controlled by the modification of cullin with the ubiquitin-like protein NEDD8(2-6). However, how CRLs catalyse ubiquitylation, and t
Autor:
Matthias Mann, Ozge Karayel, Brenda A. Schulman, J. Rajan Prabu, Arno F. Alpi, Laura A. Hehl, Susanne von Gronau, Jakub Chrustowicz, Shuai Qiao, Fynn M. Hansen, Dawafuti Sherpa, Karthik Varma Gottemukkala, Christine R. Langlois
Publikováno v:
Molecular Cell
Summary How are E3 ubiquitin ligases configured to match substrate quaternary structures? Here, by studying the yeast GID complex (mutation of which causes deficiency in glucose-induced degradation of gluconeogenic enzymes), we discover supramolecula
Autor:
Daniel Bollschweiler, Brenda A. Schulman, Arno F. Alpi, Fynn M. Hansen, Jakub Chrustowicz, Viola Beier, Christine R. Langlois, Tillman Schafer, Matthias Mann, Susanne von Gronau, Shuai Qiao, Dawafuti Sherpa, Ozge Karayel, J.R. Prabu
Publikováno v:
Molecular Cell. 77:150-163.e9
SUMMARYCells respond to environmental changes by toggling metabolic pathways, preparing for homeostasis, and anticipating future stresses. For example, inSaccharomyces cerevisiae, carbon stress-induced gluconeogenesis is terminated upon glucose avail
Autor:
Martine Moulin, Michael Haertlein, Anne L. Martel, Susanne von Gronau, François-Xavier Gallat, Dieter Oesterhelt, Gabriel J. Cuello, Bruno Demé, Irina Bagyan, Giuseppe Zaccai, Victor M. Galván Josa, Markus Neumann, Yann Fichou, Jérôme Combet, Martin Weik
Publikováno v:
Scientific Reports
Scientific Reports, 2017, 6 (31434), ⟨10.1038/srep31434⟩
'Scientific Reports ', vol: 6, pages: 31434-1-31434-12 (2016)
Scientific Reports, Nature Publishing Group, 2017, 6 (31434), ⟨10.1038/srep31434⟩
Scientific Reports, 2017, 6 (31434), ⟨10.1038/srep31434⟩
'Scientific Reports ', vol: 6, pages: 31434-1-31434-12 (2016)
Scientific Reports, Nature Publishing Group, 2017, 6 (31434), ⟨10.1038/srep31434⟩
Understanding adaptation to extreme environments remains a challenge of high biotechnological potential for fundamental molecular biology. The cytosol of many microorganisms, isolated from saline environments, reversibly accumulates molar concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b6de395a7158f08d97f5bbff7c4f65
https://hal.science/hal-01597699
https://hal.science/hal-01597699
Autor:
Orland Gonzalez, Susanne von Gronau, Friedhelm Pfeiffer, Dieter Oesterhelt, Michaela Falb, Ralf Zimmer, Eduardo R. Mendoza
Publikováno v:
Mol. BioSyst.. 4:148-159
We present a genome-scale metabolic reconstruction for the extreme halophile Halobacterium salinarum. The reconstruction represents a summary of the knowledge regarding the organism's metabolism, and has already led to new research directions and imp