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Akademický článek
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Akademický článek
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Autor:
Dingxi Zhou, Mariana Borsa, Daniel J. Puleston, Susanne Zellner, Jesusa Capera, Sharon Sanderson, Martina Schifferer, Svenja S. Hester, Xin Ge, Roman Fischer, Luke Jostins, Christian Behrends, Ghada Alsaleh, Anna Katharina Simon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Autophagy is known to impact CD4+ T cell proliferation but the identity of autophagosomal components remain unclear. Here the authors leverage a transgenic mouse model to assess the autophagosomal compartment and identify interleukin-7 receptor-α as
Externí odkaz:
https://doaj.org/article/1ccb857c105547c5b33bd8c47532fb9e
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100506- (2021)
Summary: The ascorbate peroxidase APEX2 is commonly used to study the neighborhood of a protein of interest by proximity-dependent biotinylation. Here, we describe a protocol for sample processing compatible with immunoblotting and mass spectrometry,
Externí odkaz:
https://doaj.org/article/046bb2d1a8a54597a74d18c39dfb15a1
Autor:
Christian Behrends, Susanne Zellner
Publikováno v:
Autophagy. 17:1281-1283
Selective autophagy receptors have been implicated in the degradation of cellular constituents of various size and rigidity. However, the identity of protein cargo have largely remained elusive. In our recent study, we combined limited proteolysis-en
Publikováno v:
Molecular cell 81(6), 1337-1354.e8 (2021). doi:10.1016/j.molcel.2021.01.009
Autophagy
Autophagy
Summary Autophagy deficiency in fed conditions leads to the formation of protein inclusions highlighting the contribution of this lysosomal delivery route to cellular proteostasis. Selective autophagy pathways exist that clear accumulated and aggrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a333338618dc4db6d5ad5c8dc84c93a8
https://pub.dzne.de/record/157731
https://pub.dzne.de/record/157731
Autor:
Christian Behrends, Benjamin S. Padman, Marvin Skulsuppaisarn, Michael Lazarou, Susanne Zellner, Thanh Ngoc Nguyen, Louise Uoselis
SummaryThe sequestration of damaged mitochondria within double-membrane structures termed autophagosomes is a key step of PINK1/Parkin mitophagy. The Atg4 family of proteases are thought to regulate autophagosome formation exclusively by processing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44a69106f9137c640f9a40f4e07d9c4f
https://doi.org/10.1101/2020.12.17.422596
https://doi.org/10.1101/2020.12.17.422596
Autor:
Susanne Zellner, Grace Khuu, Louise Uoselis, Benjamin S. Padman, Runa S.J. Lindblom, Marvin Skulsuppaisarn, Thanh Ngoc Nguyen, Michael Lazarou, Emily M. Watts, Wai Kit Lam, Christian Behrends
Publikováno v:
Molecular cell. 81(9)
The sequestration of damaged mitochondria within double-membrane structures termed autophagosomes is a key step of PINK1/Parkin mitophagy. The ATG4 family of proteases are thought to regulate autophagosome formation exclusively by processing the ubiq
Publikováno v:
Genomics & Genetics Weekly; 4/12/2024, p1750-1750, 1p
Autor:
Nalbach, Karsten, Schifferer, Martina, Bhattacharya, Debjani, Ho-Xuan, Hung, Tseng, Wei Chou, Williams, Luis A., Stolz, Alexandra, Lichtenthaler, Stefan F., Elazar, Zvulun, Behrends, Christian
Publikováno v:
Nature Communications; 12/15/2023, Vol. 14 Issue 1, p1-18, 18p