Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Susanne Winiwarter"'
Autor:
Susanne Winiwarter, Ernst Ahlberg, Edmund Watson, Ioana Oprisiu, Mickael Mogemark, Tobias Noeske, Nigel Greene
Publikováno v:
ADMET and DMPK, Vol 6, Iss 1, Pp 15-33 (2018)
Each year the pharmaceutical industry makes thousands of compounds, many of which do not meet the desired efficacy or pharmacokinetic properties, describing the absorption, distribution, metabolism and excretion (ADME) behavior. Parameters such as li
Externí odkaz:
https://doaj.org/article/061181c6dda34eecb16b2c797f37180f
Autor:
Olga Obrezanova, Anton Martinsson, Tom Whitehead, Samar Mahmoud, Andreas Bender, Filip Miljković, Piotr Grabowski, Ben Irwin, Ioana Oprisiu, Gareth Conduit, Matthew Segall, Graham F. Smith, Beth Williamson, Susanne Winiwarter, Nigel Greene
Publikováno v:
Molecular Pharmaceutics. 19:1488-1504
Animal pharmacokinetic (PK) data as well as human and animal in vitro systems are utilized in drug discovery to define the rate and route of drug elimination. Accurate prediction and mechanistic understanding of drug clearance and disposition in anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9bd2b4cfbc81205355cb3ed27f5a7e
https://doi.org/10.1021/acs.molpharmaceut.2c00027
https://doi.org/10.1021/acs.molpharmaceut.2c00027
Autor:
Ioana Oprisiu, Susanne Winiwarter
Modeling of absorption, distribution, metabolism and excretion properties is well established in drug discovery. Here we present principles, considerations when and how to build models and how to apply them in real life in the industrial setting. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a95070817285d3cfffea667bdd790f
https://doi.org/10.1016/b978-0-12-801238-3.11532-6
https://doi.org/10.1016/b978-0-12-801238-3.11532-6
Autor:
Ken Grime, Susanne Winiwarter, Rasmus Jansson-Löfmark, Michael Davies, Adrian J. Fretland, Rhys D.O. Jones, Paul Morgan, Dermot F. McGinnity
Publikováno v:
Trends in pharmacological sciences. 41(6)
During drug discovery and prior to the first human dose of a novel candidate drug, the pharmacokinetic (PK) behavior of the drug in humans is predicted from preclinical data. This helps to inform the likelihood of achieving therapeutic exposures in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f23152cd6345839320948ed47fc343f
https://pubmed.ncbi.nlm.nih.gov/32359836
https://pubmed.ncbi.nlm.nih.gov/32359836
Autor:
Fabio Broccatell, Prashant V. Desai, Bernard Faller, Christopher Keefer, Rieko Arimoto, George Chang, Karsten Menzel, Susanne Winiwarter
Publikováno v:
Molecular pharmaceutics. 16(9)
The fraction unbound in the incubation, fu,inc, is an important parameter to consider in the evaluation of intrinsic clearance measurements performed in vitro in hepatocytes or microsomes. Reliable estimates of fu,inc based on a compound's structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb5be8d45abc21c36fcf3c5e139017b
https://pubmed.ncbi.nlm.nih.gov/31596590
https://pubmed.ncbi.nlm.nih.gov/31596590
Autor:
Christian Löfberg, Marianne Swanson, ZhongQing Yuan, Johan Broddefalk, Annika Westin Eriksson, Susanne Winiwarter, Martin A. Hayes, Gabrielle Saarinen, Johan Meuller, Carl Whatling, Johan Ulander, Hans Emtenäs, Johan Cassel, Monica Sundqvist, Malin Lemurell, Luna Prieto Garcia, Staffan Karlsson
Publikováno v:
Journal of medicinal chemistry. 62(9)
5-Lipoxygenase (5-LO)-activating protein (FLAP) inhibitors have proven to attenuate 5-LO pathway activity and leukotriene production in human clinical trials. However, previous clinical candidates have been discontinued and the link between FLAP inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff40a6805c4be041ac624c15aa826045
https://pubmed.ncbi.nlm.nih.gov/30929436
https://pubmed.ncbi.nlm.nih.gov/30929436
Autor:
Susanne Winiwarter, Ken Grime, Adrian J. Fretland, Rhys M. Jones, Dermot F. McGinnity, Michael J. Davies, Paul Morgan, Rasmus Jansson-Löfmark
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b5c1772824acdfd31d473bc19abb5c1
https://doi.org/10.1016/j.dmpk.2020.04.208
https://doi.org/10.1016/j.dmpk.2020.04.208
Autor:
Susanne Winiwarter, Fabio Broccatelli, Holger Fischer, Rieko Arimoto, Carl Petersson, Christopher Keefer, Prashant V. Desai, Kelly E. Desino, Franco Lombardo
Publikováno v:
Journal of medicinal chemistry. 60(22)
In silico tools to investigate absorption, distribution, metabolism, excretion, and pharmacokinetics (ADME-PK) properties of new chemical entities are an integral part of the current industrial drug discovery paradigm. While many companies are active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495ca25c62cc6a68888a1bdd16d0f60d
https://pubmed.ncbi.nlm.nih.gov/28609624
https://pubmed.ncbi.nlm.nih.gov/28609624
Publikováno v:
Molecular pharmaceutics. 14(5)
In vitro permeability data have a central place in absorption risk assessments in drug discovery and development. For compounds where active efflux impacts permeability in vitro, the inherent passive membrane permeability (“intrinsic permeability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e1f2c39ba15380dbad20bdd773ae0f
https://pubmed.ncbi.nlm.nih.gov/28329446
https://pubmed.ncbi.nlm.nih.gov/28329446
Autor:
Prashant V. Desai, Bernard Faller, Christopher Keefer, Susanne Winiwarter, Fabio Broccatelli, Rieko Arimoto, George Chang, Karsten Menzel
Publikováno v:
Molecular Pharmaceutics. 16:4755-4755
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7464813cc9b90043958922a5cc7e52db
https://doi.org/10.1021/acs.molpharmaceut.9b00993
https://doi.org/10.1021/acs.molpharmaceut.9b00993