Výsledky vyhledávání - "Susanne Wilde"

Akademický článek

Codon optimization of the human papillomavirus E7 oncogene induces a CD8+ T cell response to a cryptic epitope not harbored by wild-type E7.

Autor: Felix K M Lorenz, Susanne Wilde, Katrin Voigt, Elisa Kieback, Barbara Mosetter, Dolores J Schendel, Wolfgang Uckert

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121633 (2015)

Codon optimization of nucleotide sequences is a widely used method to achieve high levels of transgene expression for basic and clinical research. Until now, immunological side effects have not been described. To trigger T cell responses against huma

Externí odkaz: https://doaj.org/article/1dc7330131824a3e95242ca3e8507f4b

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T-Cells Expressing a Highly Potent PRAME-Specific T-Cell Receptor in Combination with a Chimeric PD1-41BB Co-Stimulatory Receptor Show a Favorable Preclinical Safety Profile and Strong Anti-Tumor Reactivity

Autor: Nadja Sailer, Ina Fetzer, Melanie Salvermoser, Monika Braun, Doris Brechtefeld, Christian Krendl, Christiane Geiger, Kathrin Mutze, Elfriede Noessner, Dolores Schendel, Maja Bürdek, Susanne Wilde, Daniel Sommermeyer

Publikováno v: Cancers; Volume 14; Issue 8; Pages: 1998
Cancers 14:1998 (2022)

The hostile tumor microenvironment (TME) is a major challenge for the treatment of solid tumors with T-cell receptor (TCR)-modified T-cells (TCR-Ts), as it negatively influences T-cell efficacy, fitness, and persistence. These negative influences are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734ea08f4286c3788b7e3656b3a661de

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Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy

Autor: Luis Felipe Olguín-Contreras, Ramona Schlenker, Heinrich Leonhardt, Elfriede Noessner, Julia Schnappinger, Gerald Willimsky, Susanne Wilde, Svenja Rühland, Matthias Leisegang, Hartmann Harz, Peter J. Nelson, Anja Disovic, Wolfgang Uckert, Dolores J. Schendel

Publikováno v: Cancer Res. 77, 3577-3590 (2017)

Inherent intermediate- to low-affinity T-cell receptors (TCR) that develop during the natural course of immune responses may not allow sufficient activation for tumor elimination, making the majority of T cells suboptimal for adoptive T-cell therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9472db4879881f870b2601c13b3cef
https://doi.org/10.1158/0008-5472.can-16-1922

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Unbiased Identification of T-Cell Receptors Targeting Immunodominant Peptide-MHC Complexes for T-Cell Receptor Immunotherapy

Autor: Christian Ellinger, Wolfgang Uckert, Elisa Kieback, Felix K.M. Lorenz, Maria Lietz, Susanne Wilde, Dolores J. Schendel

Publikováno v: Human Gene Therapy

T-cell receptor (TCR) immunotherapy uses T cells engineered with new TCRs to enable detection and killing of cancer cells. Efficacy of TCR immunotherapy depends on targeting antigenic peptides that are efficiently presented by the best-suited major h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d378df839e347a0ee4d1ceb9b49864ce
https://pubmed.ncbi.nlm.nih.gov/28950731

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Misinitiation of intrathymicMART-1transcription and biased TCR usage explain the high frequency of MART-1-specific T cells

Autor: Thomas Blankenstein, Bruno Kyewski, Sheena Pinto, Dolores J. Schendel, Wolfgang Uckert, Susanne Wilde, Daniel Sommermeyer, Chloé Michel

Publikováno v: European Journal of Immunology. 44:2811-2821

Immunity to tumor differentiation antigens, such as melanoma antigen recognized by T cells 1 (MART-1), has been comprehensively studied. Intriguingly, CD8(+) T cells specific for the MART-1(26(27)-35) epitope in the context of HLA-A0201 are about 100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a44a0ba76d9fb411e37f23443bd8ff6
https://doi.org/10.1002/eji.201444499

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The CD6 Scavenger Receptor Is Differentially Expressed on a CD56dim Natural Killer Cell Subpopulation and Contributes to Natural Killer-Derived Cytokine and Chemokine Secretion

Autor: Bernadette Müller, Ludmila Umansky, Monika Braun, Dominik ter Meer, Joachim W. Ellwart, Barbara Mosetter, Silke Raffegerst, Stefani Spranger, Susanne Wilde, Barbara Simm, Dolores J. Schendel, Christine S. Falk, Tina Lerchl

Publikováno v: Journal of Innate Immunity. 3:420-434

The CD6 scavenger receptor is known to be expressed on virtually all T cells and is supposed to be involved in costimulation, synapse formation, thymic selection and leukocyte migration. Here, we demonstrate that CD6 is differentially expressed by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e9b85367b023084f6a01ab00a6cca19
https://doi.org/10.1159/000322720

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Generation of Th1-Polarizing Dendritic Cells Using the TLR7/8 Agonist CL075

Autor: Susanne Wilde, Barbara Mosetter, Dolores J. Schendel, Christiane Geiger, Maja Bürdek, Miran Javorovic, Bernhard Frankenberger, Stefani Spranger, Stefanie Tippmer, Iris Bigalke

Publikováno v: The Journal of Immunology. 185:738-747

In this paper, we describe a new method for preparation of human dendritic cells (DCs) that secrete bioactive IL-12(p70) using synthetic immunostimulatory compounds as TLR7/8 agonists. Monocyte-derived DCs were generated using a procedure that provid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c6917a215075851bbed94ea276a7b4
https://doi.org/10.4049/jimmunol.1000060

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