Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Susanne Vetterkind"'
Autor:
Robert J Saphirstein, Yuan Z Gao, Mikkel H Jensen, Cynthia M Gallant, Susanne Vetterkind, Jeffrey R Moore, Kathleen G Morgan
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62461 (2013)
Increased aortic stiffness is an acknowledged predictor and cause of cardiovascular disease. The sources and mechanisms of vascular stiffness are not well understood, although the extracellular matrix (ECM) has been assumed to be a major component. W
Externí odkaz:
https://doaj.org/article/ef1963da6e774971a2122deb8b0303e6
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30409 (2012)
A proliferative response of smooth muscle cells to activation of extracellular signal regulated kinases 1 and 2 (ERK1/2) has been linked to cardiovascular disease. In fully differentiated smooth muscle, however, ERK1/2 activation can also regulate co
Externí odkaz:
https://doaj.org/article/2c3b520dab7c443b8b834fa5a69de0fe
Autor:
Kathleen G. Morgan, Ute Preuss, Ransom H. Poythress, Terence Tao, Eunhee Lee, Eric J. Sundberg, Susanne Vetterkind
Publikováno v:
Molecular Biology of the Cell
We show here for the first time that the pro-apoptotic protein Par-4 binds to and activates myosin phosphatase (MP). During agonist stimulation, Par-4 facilitates ZIPK targeting and inhibitory phosphorylation of MP, however, phosphorylation of Par-4
Autor:
Meike Boosen, Susanne Illenberger, Jan Kubicek, Susanne Vetterkind, Ute Preuss, Karl-Heinz Scheidtmann
Publikováno v:
Molecular Biology of the Cell. 20:4010-4020
Prostate apoptosis response-4 (Par-4) was initially identified as a gene product up-regulated in prostate cancer cells undergoing apoptosis. In rat fibroblasts, coexpression of Par-4 and its interaction partner DAP-like kinase (Dlk, which is also kno
Publikováno v:
Cell Health and Cytoskeleton, Vol 2009, Iss default, Pp 1-16 (2009)
Sarah Appel1,2,6, Susanne Vetterkind1,2,6, Ansgar Koplin1,3, Barbara Maertens1,4, Meike Boosen1,5, Ute Preuss11The Institute of Genetics, University of Bonn, Bonn, Germany; 2Department of Health Sciences, Sargent College of Health and Rehabilitation
Publikováno v:
Journal of Cellular and Molecular Medicine
Smooth muscle contractile activity is a major regulator of function of the vascular system, respiratory system, gastrointestinal system and the genitourinary systems. Malfunction of contractility in these systems leads to a host of clinical disorders
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
Ceramide, a bioactive lipid and signaling molecule associated with cardiovascular disease, is known to activate extracellular signal regulated kinases 1 and 2 (ERK1/2). Here, we determined that the effect of ceramide on ERK1/2 is mediated by ceramide
Publikováno v:
Experimental Cell Research. 311:177-191
Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously ex
Publikováno v:
American journal of physiology. Cell physiology. 305(2)
Turnover of focal adhesions (FAs) is known to be critical for cell migration and adhesion of proliferative vascular smooth muscle (VSM) cells. However, it is often assumed that FAs in nonmigratory, differentiated VSM (dVSM) cells embedded in the wall
Publikováno v:
The FASEB Journal. 27