Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Susanne Tries"'
The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2
Publikováno v:
Inflammation Research. 51:135-143
Objective: We examined the effects of ML3000 and several non-steroidal antiinflammatory drugs (NSAIDs) on the synthesis of products of 5-LOX (LTB4, LTC4) and COX-1/2 (TXB2, PGE2) in vitro and ex vivo in order to further elucidate the mechanism of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2154cc41bd15c33ab20888a9529c4f9f
https://doi.org/10.1007/pl00000285
https://doi.org/10.1007/pl00000285
Autor:
Dragan V. Jovanovic, Susanne Tries, Pascal Reboul, Johanne Martel-Pelletier, Julio Cesar B. Fernandes, Jean-Pierre Pelletier, F C Jolicoeur, Stefan Laufer
Publikováno v:
Arthritis & Rheumatism. 44:2320-2330
Objective To study the therapeutic effectiveness of ML-3000, a new antiinflammatory drug that has balanced dual inhibitory activity against 5-lipoxygenase and cyclooxygenase, on the development of lesions in the experimental osteoarthritis (OA) dog m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe2f9a203c80749a32c867d2baa8b834
https://doi.org/10.1002/1529-0131(200110)44:10<2320::aid-art394>3.0.co
https://doi.org/10.1002/1529-0131(200110)44:10<2320::aid-art394>3.0.co
Autor:
Susanne Tries, Gerd Dannhardt, T. Kammermeier, Stefan Laufer, Hans-Günter Striegel, Werner Kiefer, Karola Neher, Cornelia Donat, Sibylle Baur, Pia Zechmeister, Katrin Stolingwa
Publikováno v:
Archiv der Pharmazie. 330:307-312
The aim of our study was to investigate structure activity relationship following the replacement of the 6-phenyl substituent at the 6,7-diaryl-2,3-dihydropyrrolizine template by various heteroaromatic residues. In this context we developed a new, ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbba81b4153486086297f4ce4887712
https://doi.org/10.1002/ardp.19973300908
https://doi.org/10.1002/ardp.19973300908
Publikováno v:
European Journal of Pharmacology. 271:525-531
In this study we characterized the effects of a novel anti-inflammatory drug, ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7- phenyl-2,3-dihydro-1 H -pyrrolizine-5-yl]-acetic acid), on the gastric mucosa and attempted to determine the mechanism responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0688b9482581cd0a77e1ac79ceaed3
https://doi.org/10.1016/0014-2999(94)90814-1
https://doi.org/10.1016/0014-2999(94)90814-1
Autor:
Christelle, Boileau, Johanne, Martel-Pelletier, Jean-Yves, Jouzeau, Patrick, Netter, Florina, Moldovan, Stefan, Laufer, Susanne, Tries, Jean-Pierre, Pelletier
Publikováno v:
Journal of Rheumatology
Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2002, 29 (7), pp.1446-53
Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2002, 29 (7), pp.1446-53
International audience; OBJECTIVE:2002To evaluate in vivo therapeutic efficacy of licofelone, a novel competitive dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX) in chondrocyte death in the canine ligament transection model of osteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0770406c7b5c24ca9ebddefb70c4766c
https://hal.univ-lorraine.fr/hal-01778282
https://hal.univ-lorraine.fr/hal-01778282
Autor:
Nicolás Hinrichs, Maryam Foradi, Tariq Yousef, Elisa Hartmann, Susanne Triesch, Jan Kaßel, Johannes Pein
Publikováno v:
Frontiers in Neurorobotics, Vol 16 (2022)
Meaning has been established pervasively as a central concept throughout disciplines that were involved in cognitive revolution. Its metaphoric usage comes to be, first and foremost, through the interpreter's constraint: representational relationship
Externí odkaz:
https://doaj.org/article/c201ecb6effe4e75811146b5e0f4b0bb
Publikováno v:
Pulmonary pharmacologytherapeutics. 10(3)
ML 3000 is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LO), two enzymes that contribute to the airway inflammation in asthma. When administered as an aerosol at a dose of 100 mg, 0.5 h before antigen challenge in allergic sheep, ML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9fb8b2d55de883749591c26b1081dd
https://pubmed.ncbi.nlm.nih.gov/9514627
https://pubmed.ncbi.nlm.nih.gov/9514627