Výsledky vyhledávání - "Susanne Tries"

The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2

Autor: Susanne Tries, Stefan Laufer, W. Neupert

Publikováno v: Inflammation Research. 51:135-143

Objective: We examined the effects of ML3000 and several non-steroidal antiinflammatory drugs (NSAIDs) on the synthesis of products of 5-LOX (LTB4, LTC4) and COX-1/2 (TXB2, PGE2) in vitro and ex vivo in order to further elucidate the mechanism of act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2154cc41bd15c33ab20888a9529c4f9f
https://doi.org/10.1007/pl00000285

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In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: Suppression of collagenase 1 and interleukin-1? synthesis

Autor: Dragan V. Jovanovic, Susanne Tries, Pascal Reboul, Johanne Martel-Pelletier, Julio Cesar B. Fernandes, Jean-Pierre Pelletier, F C Jolicoeur, Stefan Laufer

Publikováno v: Arthritis & Rheumatism. 44:2320-2330

Objective To study the therapeutic effectiveness of ML-3000, a new antiinflammatory drug that has balanced dual inhibitory activity against 5-lipoxygenase and cyclooxygenase, on the development of lesions in the experimental osteoarthritis (OA) dog m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe2f9a203c80749a32c867d2baa8b834
https://doi.org/10.1002/1529-0131(200110)44:10<2320::aid-art394>3.0.co

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Synthesis and Evaluation of a Novel Series of Pyrrolizine Derivatives as Dual Cyclooxygenase-1 and 5-Lipoxygenase Inhibitors

Autor: Susanne Tries, Gerd Dannhardt, T. Kammermeier, Stefan Laufer, Hans-Günter Striegel, Werner Kiefer, Karola Neher, Cornelia Donat, Sibylle Baur, Pia Zechmeister, Katrin Stolingwa

Publikováno v: Archiv der Pharmazie. 330:307-312

The aim of our study was to investigate structure activity relationship following the replacement of the 6-phenyl substituent at the 6,7-diaryl-2,3-dihydropyrrolizine template by various heteroaromatic residues. In this context we developed a new, ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbba81b4153486086297f4ce4887712
https://doi.org/10.1002/ardp.19973300908

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ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury

Autor: Stefan Laufer, John L. Wallace, Lisa Carter, Webb McKnight, Susanne Tries

Publikováno v: European Journal of Pharmacology. 271:525-531

In this study we characterized the effects of a novel anti-inflammatory drug, ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7- phenyl-2,3-dihydro-1 H -pyrrolizine-5-yl]-acetic acid), on the gastric mucosa and attempted to determine the mechanism responsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0688b9482581cd0a77e1ac79ceaed3
https://doi.org/10.1016/0014-2999(94)90814-1

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Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors

Autor: Christelle, Boileau, Johanne, Martel-Pelletier, Jean-Yves, Jouzeau, Patrick, Netter, Florina, Moldovan, Stefan, Laufer, Susanne, Tries, Jean-Pierre, Pelletier

Publikováno v: Journal of Rheumatology
Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2002, 29 (7), pp.1446-53

International audience; OBJECTIVE:2002To evaluate in vivo therapeutic efficacy of licofelone, a novel competitive dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX) in chondrocyte death in the canine ligament transection model of osteo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0770406c7b5c24ca9ebddefb70c4766c
https://hal.univ-lorraine.fr/hal-01778282

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The effects of ML 3000 on antigen-induced responses in sheep

Autor: William M. Abraham, Stefan Laufer, Susanne Tries

Publikováno v: Pulmonary pharmacologytherapeutics. 10(3)

ML 3000 is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LO), two enzymes that contribute to the airway inflammation in asthma. When administered as an aerosol at a dose of 100 mg, 0.5 h before antigen challenge in allergic sheep, ML

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9fb8b2d55de883749591c26b1081dd
https://pubmed.ncbi.nlm.nih.gov/9514627

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