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Autor:
Karin Calles, Steven W. Muchmore, Anna Karin Ramqvist, Mats Carlquist, Jie Yang, Maria Alarcon, Jan Carlstedt-Duke, Owe Engström, John M. Harlan, Jan-Åke Gustafsson, Susanne Thorell, Harri Ahola, Björn Kauppi, Jonathan Greer, Clarissa G. Jakob, Lars Öhman, Mathias Färnegårdh
Publikováno v:
Journal of Biological Chemistry. 278:22748-22754
Here we describe the three-dimensional crystal structures of human glucocorticoid receptor ligand-binding domain (GR-LBD) in complex with the antagonist RU-486 at 2.3 A resolution and with the agonist dexamethasone ligand together with a coactivator