Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Susanne S, Hille"'
Autor:
Binh Y. Nguyen, Fangchao Zhou, Pablo Binder, Wei Liu, Susanne S. Hille, Xiaojing Luo, Min Zi, Hongyuan Zhang, Antony Adamson, Fozia Z. Ahmed, Sam Butterworth, Elizabeth J. Cartwright, Oliver J. Müller, Kaomei Guan, Elizabeth M. Fitzgerald, Xin Wang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 12 (2023)
Background Prolonged activation of angiotensin II is the main mediator that contributes to the development of heart diseases, so converting angiotensin II into angiotensin 1‐7 has emerged as a new strategy to attenuate detrimental effects of angiot
Externí odkaz:
https://doaj.org/article/0de15311822a4ff99e0f184b803b44a8
Autor:
Andrea Ruiz-Velasco, Rida Raja, Xinyi Chen, Haresh Ganenthiran, Namrita Kaur, Nasser hawimel o Alatawi, Jessica M. Miller, Riham R.E. Abouleisa, Qinghui Ou, Xiangjun Zhao, Oveena Fonseka, Xin Wang, Susanne S. Hille, Norbert Frey, Tao Wang, Tamer M.A. Mohamed, Oliver J. Müller, Elizabeth J. Cartwright, Wei Liu
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106970- (2023)
Summary: Despite the development of clinical treatments, heart failure remains the leading cause of mortality. We observed that p21-activated kinase 3 (PAK3) was augmented in failing human and mouse hearts. Furthermore, mice with cardiac-specific PAK
Externí odkaz:
https://doaj.org/article/0b1e474d4e224701832effe508afdc92
Autor:
Pablo Binder, Binh Nguyen, Lucy Collins, Min Zi, Wei Liu, Foteini Christou, Xiaojing Luo, Susanne S. Hille, Norbert Frey, Elizabeth J. Cartwright, Jonathan Chernoff, Oliver J. Müller, Kaomei Guan, Xin Wang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Endoplasmic Reticulum (ER) stress and oxidative stress have been highly implicated in the pathogenesis of cardiac hypertrophy and heart failure (HF). However, the mechanisms involved in the interplay between these processes in the heart are not fully
Externí odkaz:
https://doaj.org/article/cf127567c6ca4514b48d2a9c96e5f4e9
Autor:
Namrita Kaur, Andrea Ruiz-Velasco, Rida Raja, Gareth Howell, Jessica M. Miller, Riham R.E. Abouleisa, Qinghui Ou, Kimberly Mace, Susanne S. Hille, Norbert Frey, Pablo Binder, Craig P. Smith, Helene Fachim, Handrean Soran, Eileithyia Swanton, Tamer M.A. Mohamed, Oliver J. Müller, Xin Wang, Jonathan Chernoff, Elizabeth J. Cartwright, Wei Liu
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103973- (2022)
Summary: Myocardial inflammation contributes to cardiomyopathy in diabetic patients through incompletely defined underlying mechanisms. In both human and time-course experimental samples, diabetic hearts exhibited abnormal ER, with a maladaptive shif
Externí odkaz:
https://doaj.org/article/60aa8df0966d4271a72fa6689cc50467
Autor:
Maren Leifheit-Nestler, Miriam A. Wagner, Beatrice Richter, Corinna Piepert, Fiona Eitner, Ineke Böckmann, Isabel Vogt, Andrea Grund, Susanne S. Hille, Ariana Foinquinos, Karina Zimmer, Thomas Thum, Oliver J. Müller, Dieter Haffner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Fibroblast growth factor (FGF) 23 is elevated in chronic kidney disease (CKD) to maintain phosphate homeostasis. FGF23 is associated with left ventricular hypertrophy (LVH) in CKD and induces LVH via klotho-independent FGFR4-mediated activation of ca
Externí odkaz:
https://doaj.org/article/3349e8822e104c229171bc3e03462d46
Autor:
Andrea Ruiz-Velasco, Min Zi, Susanne S Hille, Tayyiba Azam, Namrita Kaur, Juwei Jiang, Binh Nguyen, Karolina Sekeres, Pablo Binder, Lucy Collins, Fay Pu, Han Xiao, Kaomei Guan, Norbert Frey, Elizabeth J Cartwright, Oliver J Müller, Xin Wang, Wei Liu
Publikováno v:
eLife, Vol 9 (2020)
Myocardial insulin resistance contributes to heart failure in response to pathological stresses, therefore, a therapeutic strategy to maintain cardiac insulin pathways requires further investigation. We demonstrated that insulin receptor substrate 1
Externí odkaz:
https://doaj.org/article/e82f66576f0d4a39814f48fb1341eaf7
Autor:
Luka Nicin, Sam Michael Schroeter, Simone Franziska Glaser, Ralf Schulze-Brüning, Minh-Duc Pham, Susanne S. Hille, Michail Yekelchyk, Badder Kattih, Wesley Tyler Abplanalp, Lukas Tombor, Oliver J. Müller, Thomas Braun, Benjamin Meder, Christoph Reich, Mani Arsalan, Tomas Holubec, Thomas Walther, Fabian Emrich, Jaya Krishnan, Andreas M. Zeiher, David John, Stefanie Dimmeler
Publikováno v:
Nature Cardiovascular Research. 1:174-185
Pathological cardiac hypertrophy is a leading cause of heart failure, but knowledge of the full repertoire of cardiac cells and their gene expression profiles in the human hypertrophic heart is missing. Here, by using large-scale single-nucleus trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::981aa3bc630c6211853e8aa27779fb04
https://doi.org/10.1038/s44161-022-00019-7
https://doi.org/10.1038/s44161-022-00019-7
Autor:
Andrea, Ruiz-Velasco, Min, Zi, Susanne S, Hille, Tayyiba, Azam, Namrita, Kaur, Juwei, Jiang, Binh, Nguyen, Karolina, Sekeres, Pablo, Binder, Lucy, Collins, Fay, Pu, Han, Xiao, Kaomei, Guan, Norbert, Frey, Elizabeth J, Cartwright, Oliver J, Müller, Xin, Wang, Wei, Liu
Publikováno v:
eLife
Myocardial insulin resistance contributes to heart failure in response to pathological stresses, therefore, a therapeutic strategy to maintain cardiac insulin pathways requires further investigation. We demonstrated that insulin receptor substrate 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::024d48474d5a11a88ecf6db7245f35b4
https://pubmed.ncbi.nlm.nih.gov/32223896
https://pubmed.ncbi.nlm.nih.gov/32223896
Autor:
Wu Y; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Foollee A; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Chan AY; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Hille S; Department of Internal Medicine V, University Hospital of Schleswig-Holstein, Campus Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Kiel, Germany., Hauke J; Division of Inherited Metabolic Diseases, University Children's Hospital, Heidelberg, Germany., Challis MP; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Johnson JL; Meyer Cancer Center, Weill Cornell Medicine, New York, USA.; Department of Cell Biology, Harvard Medical School, Boston, USA.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA., Yaron TM; Meyer Cancer Center, Weill Cornell Medicine, New York, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, USA.; Columbia University Vagelos College of Physicians and Surgeons, New York, USA., Mynard V; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Aung OH; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Cleofe MAS; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Huang C; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia.; Monash Proteomics and Metabolomics Platform, Monash University, Victoria, Australia., Lim Kam Sian TCC; Monash Proteomics and Metabolomics Platform, Monash University, Victoria, Australia., Rahbari M; German Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Im Neuenheimer Feld 280, Heidelberg, Germany.; University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Department of Surgery, Theodor-Kutzer-Ufer 1-3, Heidelberg, Germany.; University Tuebingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3-Research Center for Malignome, Metabolome and Microbiome, Otfried-Müller-Straße 37, Tübingen, Germany., Gallage S; German Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Im Neuenheimer Feld 280, Heidelberg, Germany.; University Tuebingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3-Research Center for Malignome, Metabolome and Microbiome, Otfried-Müller-Straße 37, Tübingen, Germany., Heikenwalder M; German Cancer Research Center (DKFZ), Division of Chronic Inflammation and Cancer, Im Neuenheimer Feld 280, Heidelberg, Germany.; University Tuebingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3-Research Center for Malignome, Metabolome and Microbiome, Otfried-Müller-Straße 37, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard-Karls University, Tübingen, Germany., Cantley LC; Meyer Cancer Center, Weill Cornell Medicine, New York, USA.; Department of Cell Biology, Harvard Medical School, Boston, USA.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA., Schittenhelm RB; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia.; Monash Proteomics and Metabolomics Platform, Monash University, Victoria, Australia., Formosa LE; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Smith GC; School of Biomedical Sciences, University of New South Wales, Sydney, Australia., Okun JG; Division of Inherited Metabolic Diseases, University Children's Hospital, Heidelberg, Germany., Müller OJ; Department of Internal Medicine V, University Hospital of Schleswig-Holstein, Campus Kiel, Germany.; German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Kiel, Germany., Rusu PM; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia., Rose AJ; Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia. adam.rose@monash.edu.; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria, Australia. adam.rose@monash.edu.
Publikováno v:
Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8390. Date of Electronic Publication: 2024 Sep 27.
Autor:
Hernandez Torres LD; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany., Rezende F; Institute for Cardiovascular Physiology, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.; DZHK (German Center for Cardiovascular Research) Partner Site Rhine-Main, Germany., Peschke E; Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel University, Kiel, Germany., Will O; Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel University, Kiel, Germany., Hövener JB; Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, Universitätsklinikum Schleswig-Holstein (UKSH), Kiel University, Kiel, Germany., Spiecker F; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany., Özorhan Ü; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany., Lampe J; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany., Stölting I; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany., Aherrahrou Z; Institute for Cardiogenetics, University Lübeck; University of Lübeck, Lübeck, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany., Künne C; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Kusche-Vihrog K; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany.; Institute for Physiology, University Lübeck, Lübeck, Germany., Matschl U; Department Virus Immunology, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany., Hille S; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany.; Department of Internal Medicine III, University Hospital Schleswig-Holstein, Kiel, Germany., Brandes RP; Institute for Cardiovascular Physiology, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.; DZHK (German Center for Cardiovascular Research) Partner Site Rhine-Main, Germany., Schwaninger M; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany.; CBBM (Centre for Brain, Behavior and Metabolism), University of Lübeck, Lübeck, Germany., Müller OJ; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany.; Department of Internal Medicine III, University Hospital Schleswig-Holstein, Kiel, Germany., Raasch W; Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany.; CBBM (Centre for Brain, Behavior and Metabolism), University of Lübeck, Lübeck, Germany.
Publikováno v:
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Feb 26; Vol. 15, pp. 1338458. Date of Electronic Publication: 2024 Feb 26 (Print Publication: 2024).