Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Susanne Opravil"'
Autor:
Susanne Opravil, Melania Bruno, Sebastian Kostrhon, Otto Hudecz, Karl Mechtler, Etienne Beltzung, Tanja Kaufmann, Dea Slade, Graham Warren, Andreas Brachner, Eva Kukolj
Publikováno v:
Journal of Cell Science
Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the pathology of cancer, neurodegenerative diseases and progeria. Here, we show that SIRT2 depletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d6cf6868e49a59017358561e113bc8
https://doi.org/10.1242/jcs.192633
https://doi.org/10.1242/jcs.192633
Autor:
Thomas Manke, Valentina Perrera, Johannes Popow, Borbala Gerle, Thomas Jenuwein, Nicholas Shukeir, Susanne Opravil, Michaela Pagani, Manuela Scaranaro, Aydan Bulut-Karslioglu, Suzanne van de Nobelen, Thomas Brabletz, Simone Meidhof, Monika Lachner, Inti A. De La Rosa-Velázquez
Publikováno v:
Nature Structural and Molecular Biology
Heterochromatin is important for genome integrity and stabilization of gene-expression programs. We have identified the transcription factors Pax3 and Pax9 as redundant regulators of mouse heterochromatin, as they repress RNA output from major satell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662dba6507bd51d3e54004d74d6fe775
https://doi.org/10.1038/nsmb.2382
https://doi.org/10.1038/nsmb.2382
Autor:
Stephen Malin, Monika Kauer, Gunnar Schotta, Arkady Celeste, Inti A. De La Rosa-Velázquez, André Nussenzweig, Thomas Jenuwein, Roopsha Sengupta, Elsa Callen, Susanne Opravil, Mark T. Bedford, Alexsandra Espejo, Michaela Pagani, Stefan Kubicek, Meinrad Busslinger
Publikováno v:
Genes & Development. 22:2048-2061
H4K20 methylation is a broad chromatin modification that has been linked with diverse epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct mono-, di-, and trimethylation states controlling different biological outp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e1040163332d2cc6390aa375fd7204
https://doi.org/10.1101/gad.476008
https://doi.org/10.1101/gad.476008
Autor:
Thomas Jenuwein, Brandon J. Placek, Roopsha Sengupta, Shelley L. Berger, Jing Huang, Stefan Kubicek, Jean Dorsey, Laura Perez-Burgos, Mario Richter, Susanne Opravil
Publikováno v:
Nature. 444:629-632
Specific sites of lysine methylation on histones correlate with either activation or repression of transcription. The tumour suppressor p53 (refs 4-7) is one of only a few non-histone proteins known to be regulated by lysine methylation. Here we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfb7f050e1ce2eeb874e5c4ffb3964a
https://doi.org/10.1038/nature05287
https://doi.org/10.1038/nature05287
Autor:
Masato Yonezawa, Roopsha Sengupta, Thomas Jenuwein, Stefan Kubicek, Susanne Opravil, Barna D. Fodor, Gunnar Schotta, Roderick J. O'Sullivan, Laura Perez-Burgos, Karl Mechtler
Publikováno v:
Genes & Development. 20:1557-1562
Histone lysine trimethyl states represent some of the most robust epigenetic modifications in eukaryotic chromatin. Using a candidate approach, we identified the subgroup of murine Jmjd2 proteins to antagonize H3K9me3 at pericentric heterochromatin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49860968c6292698d1be035a54780eed
https://doi.org/10.1101/gad.388206
https://doi.org/10.1101/gad.388206
Autor:
Karl Mechtler, Alwin A.H.A. Derijck, Antoine H.F.M. Peters, Susanne Opravil, Stefan Kubicek, Makoto Tachibana, Laura Perez-Burgos, Alexander Kohlmaier, Joost H.A. Martens, Roderick J. O'Sullivan, Yoichi Shinkai, Thomas Jenuwein
Publikováno v:
Molecular Cell. 12:1577-1589
Methylation of position-specific lysine residues in histone N termini is a central modification for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist in a mono-, di-, or trimethylated state, thereby extending
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ec8164d36360d110208ed7f6c6f955
https://doi.org/10.1016/s1097-2765(03)00477-5
https://doi.org/10.1016/s1097-2765(03)00477-5
Autor:
Götz Laible, Hartmut Beug, Stephan Sauer, E M Deiner, Susanne Opravil, Thomas Jenuwein, Antoine H.F.M. Peters, Stefan Czvitkovich, Andrea Wolf
Publikováno v:
Mechanisms of Development. 107:141-153
The development of multi-cellular organisms is regulated by the ordered definition of gene expression programmes that govern cell proliferation and differentiation. Although differential gene activity is mainly controlled by transcription factors, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c86b90acf5a1e83ef83a884fc7d882
https://doi.org/10.1016/s0925-4773(01)00464-6
https://doi.org/10.1016/s0925-4773(01)00464-6
Autor:
Mark T. Bedford, Susanne Opravil, Roopsha Sengupta, Min Gyu Lee, Alexsandra Espejo, Ramin Shiekhattar, Jing Huang, Jean Dorsey, Mario Richter, Thomas Jenuwein, Shelley L. Berger
Publikováno v:
Nature. 449(7158)
p53, the tumour suppressor and transcriptional activator, is regulated by numerous post-translational modifications, including lysine methylation. Histone lysine methylation has recently been shown to be reversible; however, it is not known whether n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32821fa0b46e545d810a208efdb1ef30
https://pubmed.ncbi.nlm.nih.gov/17805299
https://pubmed.ncbi.nlm.nih.gov/17805299
Autor:
Peter Steinlein, Joost H.A. Martens, Ulrich Braunschweig, Thomas Jenuwein, Martin Radolf, Susanne Opravil, Roderick J. O'Sullivan
Publikováno v:
The EMBO journal. 24(4)
Histone lysine methylation has been shown to index silenced chromatin regions at, for example, pericentric heterochromatin or of the inactive X chromosome. Here, we examined the distribution of repressive histone lysine methylation states over the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69d84bf41bf0c09041794e60acf6a41
https://pubmed.ncbi.nlm.nih.gov/15678104
https://pubmed.ncbi.nlm.nih.gov/15678104