Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Susanne N Wijesinghe"'
Autor:
Dominika E Nanus, Amel Badoume, Susanne N Wijesinghe, Andrea M Halsey, Patrick Hurley, Zubair Ahmed, Rajesh Botchu, Edward T Davis, Mark A Lindsay, Simon W Jones
Publikováno v:
EBioMedicine, Vol 72, Iss , Pp 103618- (2021)
Background: Synovial inflammation is associated with pain severity in patients with knee osteoarthritis (OA). The aim here was to determine in a population with knee OA, whether synovial tissue from areas associated with pain exhibited different syno
Externí odkaz:
https://doaj.org/article/3c99bc064d4d4e56b58ca412a83fe2e2
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Fundamentally defined by an imbalance in energy consumption and energy expenditure, obesity is a significant risk factor of several musculoskeletal conditions including osteoarthritis (OA). High-fat diets and sedentary lifestyle l
Externí odkaz:
https://doaj.org/article/19521323eeab4ca09c859430444563e7
Autor:
Susanne N. Wijesinghe, Amel Badoume, Dominika E. Nanus, Archana Sharma‐Oates, Hussein Farah, Michelangelo Certo, Fawzeyah Alnajjar, Edward T. Davis, Claudio Mauro, Mark A. Lindsay, Simon W. Jones
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Background Osteoarthritis (OA), a multifaceted condition, poses a significant challenge for the successful clinical development of therapeutics due to heterogeneity. However, classifying molecular endotypes of OA pathogenesis could provide i
Externí odkaz:
https://doaj.org/article/1142083adc274182abcfcae9a7dd5f03
Autor:
Susanne N. Wijesinghe, James Anderson, Thomas J. Brown, Dominika E. Nanus, Bas Housmans, Jonathan A. Green, Matthias Hackl, Katie K. Choi, Kenton P. Arkill, Tim Welting, Victoria James, Simon W. Jones, Mandy J. Peffers
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Extracellular vesicles are mediators of intercellular communication with critical roles in cellular senescence and ageing. In arthritis, senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogen
Externí odkaz:
https://doaj.org/article/c49b97758dc34b9ea0fdad74a58e4a59
Autor:
Thomas A. Nicholson, Michael Sagmeister, Susanne N. Wijesinghe, Hussein Farah, Rowan S. Hardy, Simon W. Jones
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 237 (2023)
Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions worldwide, for which there remains a great clinical need to develop safer and more efficacious p
Externí odkaz:
https://doaj.org/article/3c50e07dfebf40e6ad3ecf4a810d2210
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 902 (2021)
Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA
Externí odkaz:
https://doaj.org/article/ea63f11212f240438cb191fb98936769
Autor:
Fawzeyah A. Alnajjar, Archana Sharma-Oates, Susanne N. Wijesinghe, Hussein Farah, Dominika E. Nanus, Tom Nicholson, Edward T. Davis, Simon W. Jones
Publikováno v:
Cells, Vol 10, Iss 4, p 786 (2021)
Metastasis Associated Lung Adenocarcinoma Transcript-1 (MALAT1) is implicated in regulating the inflammatory response and in the pathology of several chronic inflammatory diseases, including osteoarthritis (OA). The purpose of this study was to exami
Externí odkaz:
https://doaj.org/article/3b7d05295f87476797ed7b939b795d36
Autor:
Mark J. Pearson, Edward T. Davis, Mark A. Lindsay, Susanne N. Wijesinghe, Dominika E Nanus, Simon W. Jones, Marina R. Hadjicharalambous, Alex Rosser
Publikováno v:
Arthritis & Rheumatology. 72:609-619
To identify long noncoding RNAs (lncRNAs) associated with the inflammatory phenotype of synovial fibroblasts from obese patients with osteoarthritis (OA), and to explore the expression and function of these lncRNAs.Synovium was collected from normal-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d2293b78c383a7391d6c829e6b0383
https://doi.org/10.1002/art.41158
https://doi.org/10.1002/art.41158
Publikováno v:
Advances in experimental medicine and biology. 1363
The last decade has seen an enormous increase in long non-coding RNA (lncRNA) research within rheumatology. LncRNAs are arbitrarily classed as non-protein encoding RNA transcripts that exceed 200 nucleotides in length. These transcripts have tissue a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28e03a402c41b85a7f258c6b0d334592
https://pubmed.ncbi.nlm.nih.gov/35220565
https://pubmed.ncbi.nlm.nih.gov/35220565
Osteoarthritis and rheumatoid arthritis are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both osteoarthrit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59140c7ea1836d53f7c53050af7b51b
