Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

Autor: Melissa A Lopes Pinheiro, Alwin Kamermans, Juan J Garcia-Vallejo, Bert van het Hof, Laura Wierts, Tom O'Toole, Daniël Boeve, Marleen Verstege, Susanne MA van der Pol, Yvette van Kooyk, Helga E de Vries, Wendy WJ Unger

Publikováno v: eLife, Vol 5 (2016)

Trafficking of myelin-reactive CD4+ T-cells across the brain endothelium, an essential step in the pathogenesis of multiple sclerosis (MS), is suggested to be an antigen-specific process, yet which cells provide this signal is unknown. Here we provid

Externí odkaz: https://doaj.org/article/db99249af9954e84858c02205af0425f

Barriers and facilitators of healthcare access for long COVID-19 patients in a universal healthcare system: qualitative evidence from Austria

Autor: Peter Gamillscheg, Agata Łaszewska, Stefanie Kirchner, Kathryn Hoffmann, Judit Simon, Susanne Mayer

Publikováno v: International Journal for Equity in Health, Vol 23, Iss 1, Pp 1-20 (2024)

Abstract Background Long COVID-19 challenges health and social systems globally. International research finds major inequalities in prevalence and healthcare utilization as patients describe difficulties with accessing health care. In order to improv

Externí odkaz: https://doaj.org/article/24c23f6e0d414afda0241197f4b4d0f4

Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment

Autor: David Liberg, Petter Skoog, Caitríona Grönberg, Nils Hansen, Pablo Peña-Martínez, Katrin Reinbach, Finja C Hansen, Susanne Larsson Faria, Kawther Abdilleh, Susanne Magnusson, Karin von Wachenfeldt, Camilla Rydberg Millrud, Marcus Järås

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 12 (2024)

Background Pancreatic ductal adenocarcinoma (PDAC) represents a major clinical challenge due to its tumor microenvironment, which exhibits immune-suppressive properties that facilitate cancer progression, metastasis, and therapy resistance. Interleuk

Externí odkaz: https://doaj.org/article/112dc3e1ca4c43338ff8cc2c448e9390

Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance

Autor: Nafise Elahpour, Isabella Niesner, Nora Abdellaoui, Boris Michael Holzapfel, Lukas Gritsch, Edouard Jallot, Susanne Mayer‐Wagner, Jonathan Lao

Publikováno v: Advanced Materials Interfaces, Vol 11, Iss 32, Pp n/a-n/a (2024)

Abstract This work focuses on combating bacterial infections in bone tissue using metal elements embedded in bioactive glass. While there is an urgent need for alternative methods with a shrinking number of effective treatment options untouched by an

Externí odkaz: https://doaj.org/article/54777ac0608e4fa694a4d26af96dc4b0

Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

Autor: Lynn van Olst, Sabela Rodríguez-Lorenzo, Carla Rodriguez-Mogeda, Alwin Kamermans, Susanne MA van der Pol, Ernesto Rodríguez, Gijs Kooij, Helga E de Vries

Publikováno v: eLife, 11:e73849. eLife Sciences Publications Limited
Rodríguez-Lorenzo, S, van Olst, L, Rodriguez-Mogeda, C, Kamermans, A, van der Pol, S M A, Rodríguez, E, Kooij, G & de Vries, H E 2022, ' Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis ', eLife, vol. 11, e73849 . https://doi.org/10.7554/eLife.73849

Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell infiltration resulting in lesions that preferentially affect periventricular areas of the brain. Despite research efforts to define the role of various immune cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef866329af3b534fb459b186be88dfa2
https://research.vumc.nl/en/publications/43c9c4c2-2cab-48c3-87e2-d072a6ced38e