Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Susanne M.A. Lens"'
Autor:
Sandra Tavares, Nalan Liv, Milena Pasolli, Mark Opdam, Max A.K. Rätze, Manuel Saornil, Lilian M. Sluimer, Rutger C.C. Hengeveld, Robert van Es, Erik van Werkhoven, Harmjan Vos, Holger Rehmann, Boudewijn M.T. Burgering, Hendrika M. Oosterkamp, Susanne M.A. Lens, Judith Klumperman, Sabine C. Linn, Patrick W.B. Derksen
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110584- (2022)
Summary: Elevated expression of non-receptor tyrosine kinase FER is an independent prognosticator that correlates with poor survival of high-grade and basal/triple-negative breast cancer (TNBC) patients. Here, we show that high FER levels are also as
Externí odkaz:
https://doaj.org/article/9434a26e702a448687ec52764f334902
Autor:
Michael A. Hadders, Susanne M.A. Lens
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110053- (2021)
Recent work published in Cell Reports and Developmental Cell from Sen et al., Orr et al., and Papini et al., demonstrates that midzone-based Aurora B resolves chromosome segregation errors during anaphase.
Externí odkaz:
https://doaj.org/article/a74aa936f6714b989bef40467b01c349
Autor:
Armando van der Horst, Martijn J.M. Vromans, Kim Bouwman, Maike S. van der Waal, Michael A. Hadders, Susanne M.A. Lens
Publikováno v:
Cell Reports, Vol 12, Iss 3, Pp 380-387 (2015)
The chromosomal passenger complex is essential for error-free chromosome segregation and proper execution of cytokinesis. To coordinate nuclear division with cytoplasmic division, its enzymatic subunit, Aurora B, relocalizes from centromeres in metap
Externí odkaz:
https://doaj.org/article/8f7d8b52b1814732a3fb7dcab23348bb
Publikováno v:
Cell Reports, Vol 11, Iss 4, Pp 508-515 (2015)
Correction of faulty kinetochore-microtubule attachments is essential for faithful chromosome segregation and dictated by the opposing activities of Aurora B kinase and PP1 and PP2A phosphatases. How kinase and phosphatase activities are appropriatel
Externí odkaz:
https://doaj.org/article/d31b4d3a59584aeab3fadca88b951887
Autor:
Susanne M.A. Lens, Michael A. Hadders
Publikováno v:
Trends in Cell Biology. 32:165-176
The Chromosomal Passenger Complex (CPC) regulates a plethora of processes during multiple stages of nuclear and cytoplasmic division. Early during mitosis, the CPC is recruited to centromeres and kinetochores, and ensures that the duplicated chromoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7437ccf60dc31a93b106d798a6ec99c9
https://doi.org/10.1016/j.tcb.2021.09.008
https://doi.org/10.1016/j.tcb.2021.09.008
Autor:
Sippe G. de Vries, Wigard P. Kloosterman, Holger Rehmann, William Cross, Myrna van den Bos, Sander Boymans, Bingxin Lu, Susanne M.A. Lens, Hugo J. Snippert, Yannik Bollen, Markus J. van Roosmalen, Maximilian Mossner, Nicolle Besselink, Ellen Stelloo, Christopher Kimberley, Edwin Cuppen, Chris P. Barnes, Petra van Leenen, Bas Ponsioen, Ana C. F. Bolhaqueiro, Koen C. Oost, Bastiaan van der Roest, Trevor A. Graham, Andrea Sottoriva, Geert J. P. L. Kops, Leon W.M.M. Terstappen
Publikováno v:
Nature Genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at single-cell resolution. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651f73d2429a0f3686a912f64c06f306
https://doi.org/10.1038/s41588-021-00891-2
https://doi.org/10.1038/s41588-021-00891-2
Autor:
Maria Alba Abad, Tanmay Gupta, Michael A. Hadders, Amanda Meppelink, J. Pepijn Wopken, Elizabeth Blackburn, Juan Zou, Anjitha Gireesh, Lana Buzuk, David A. Kelly, Toni McHugh, Juri Rappsilber, Susanne M.A. Lens, A. Arockia Jeyaprakash
Publikováno v:
Abad, M A, Gupta, T, Hadders, M A, Meppelink, A, Wopken, J P, Blackburn, E, Zou, J, Gireesh, A, Buzuk, L, Kelly, D A, Mchugh, T, Rappsilber, J, Lens, S M A & Jeyaprakash, A A 2022, ' Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC ', Journal of Cell Biology, vol. 221, no. 8, e202108156 . https://doi.org/10.1083/jcb.202108156
Centromere association of the chromosomal passenger complex (CPC; Borealin-Survivin-INCENP-Aurora B) and Sgo1 is crucial for chromosome biorientation, a process essential for error-free chromosome segregation. Phosphorylated histone H3 Thr3 (H3T3ph;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ae4c5c79dc9b650c4f811ebf002969
https://hdl.handle.net/20.500.11820/cf915011-2082-4fe9-9947-a47297790207
https://hdl.handle.net/20.500.11820/cf915011-2082-4fe9-9947-a47297790207
Autor:
My Anh Truong, Paula Cané-Gasull, Sippe G. de Vries, Wilco Nijenhuis, René Wardenaar, Lukas C. Kapitein, Floris Foijer, Susanne M.A. Lens
Various cancer types exhibit highly characteristic and recurrent aneuploidy patterns. The origin of these cancer type-specific karyotypes, and the extent to which they contribute to cancer progression, remains to be elucidated, partly because introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd94051b7d8b39ff14429aca6bf1f81d
https://doi.org/10.1101/2022.04.19.488790
https://doi.org/10.1101/2022.04.19.488790
Autor:
Susanne M.A. Lens, Michael A. Hadders
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110053-(2021)
Recent work published in Cell Reports and Developmental Cell from Sen et al., Orr et al., and Papini et al., demonstrates that midzone-based Aurora B resolves chromosome segregation errors during anaphase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115b7d8e634b01913b18dbe97b614dec
http://www.sciencedirect.com/science/article/pii/S2211124721015394
http://www.sciencedirect.com/science/article/pii/S2211124721015394
Autor:
A. Arockia Jeyaprakash, Juan Zou, Michael A. Hadders, Elizabeth A. Blackburn, A. Meppelink, J. P. Wopken, Susanne M.A. Lens, David A. Kelly, Juri Rappsilber, L. Buzuk, Maria Alba Abad, Tanmay Gupta, Toni McHugh
The Chromosomal Passenger Complex (CPC; consisting of Borealin, Survivin, INCENP and Aurora B kinase) and Shugoshin 1 (Sgo1) are key regulators of chromosome bi-orientation, a process essential for error-free chromosome segregation. Their functions r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d04aa69708a41656863ce91358a0c4
https://doi.org/10.1101/2021.08.27.457910
https://doi.org/10.1101/2021.08.27.457910