Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Susanne M. Mesoy"'
Publikováno v:
Membranes, Vol 13, Iss 12, p 891 (2023)
Pentameric ligand-gated ion channels (pLGICs) are expressed throughout the central and peripheral nervous systems of vertebrates and modulate many aspects of human health and disease. Recent structural and computational data indicate that cation-sele
Externí odkaz:
https://doaj.org/article/237219fc488f42eb89ab2e9ce9551469
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The role of the outermost helix (M4) in the pentameric ligand-gated ion channel (pLGIC) family is currently not fully understood. It is known that M4 is important for receptor assembly, possibly via interactions with neighboring M1 and M3 helices. M4
Externí odkaz:
https://doaj.org/article/82b405b4e307446ea224497828184d1b
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1251 (2022)
GABAAρ receptors are a subfamily of the GABAA receptor family of pentameric ligand-gated ion channels (pLGICs). Each subunit has a common structure, including a transmembrane domain of four α-helices (M1–M4). The aim of this study was to identify
Externí odkaz:
https://doaj.org/article/44c4d9046fcc4db282184a141e69b4c9
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic transmission and are crucial drug targets. Their gating mechanism is triggered by ligand binding in the extracellular domain that culminates in the opening of a hydrophobic gate in t
Externí odkaz:
https://doaj.org/article/510b7435334741cea2c5c6ec00efd983
Publikováno v:
ACS Chemical Neuroscience. 13:2338-2345
Publikováno v:
ACS chemical neuroscience. 13(15)
5-HT
Publikováno v:
ACS Chemical Neuroscience. 10:3167-3172
5-HT3 receptors are members of the family of pentameric ligand gated ion channels (pLGICs). Each subunit has four transmembrane α-helices (M1-M4), with M4 being most distant from the central pore. Residues in this α-helix interact with adjacent lip
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic transmission and are crucial drug targets. Their gating mechanism is triggered by ligand binding in the extracellular domain that culminates in the opening of a hydrophobic gate in t
Autor:
Sarah C. R. Lummis, Susanne M. Mesoy
Publikováno v:
ACS chemical neuroscience. 12(1)
Nicotinic acetylcholine receptors (nAChR) are the archetypal members of the pentameric ligand-gated ion channel (pLGIC) family, an important class of cell signaling proteins. In all members of this family, each of the five subunits has four transmemb
Publikováno v:
Biophysical Journal. 121:384a