Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Susanne M Krug"'
Autor:
Silke S Zakrzewski, Jan F Richter, Susanne M Krug, Britta Jebautzke, In-Fah M Lee, Juliane Rieger, Monika Sachtleben, Angelika Bondzio, Jörg D Schulzke, Michael Fromm, Dorothee Günzel
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79643 (2013)
Cell lines matching the source epithelium are indispensable for investigating porcine intestinal transport and barrier properties on a subcellular or molecular level and furthermore help to reduce animal usage. The porcine jejunal cell line IPEC-J2 i
Externí odkaz:
https://doaj.org/article/16ba4617e0394c8081afad0bee7a5681
Autor:
Shabnam Shalapour, Katrin Deiser, Anja A Kühl, Rainer Glauben, Susanne M Krug, André Fischer, Ozen Sercan, Stephane Chappaz, Stefan Bereswill, Markus M Heimesaat, Christoph Loddenkemper, Michael Fromm, Daniela Finke, Günter J Hämmerling, Bernd Arnold, Britta Siegmund, Thomas Schüler
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31939 (2012)
Interleukin-7 (IL-7) is a major survival factor for mature T cells. Therefore, the degree of IL-7 availability determines the size of the peripheral T cell pool and regulates T cell homeostasis. Here we provide evidence that IL-7 also regulates the h
Externí odkaz:
https://doaj.org/article/f3494e1e70364c1b87b8d04a4f9dc151
Autor:
Jeremy Tsung-Chieh Chen, Xiawei Hu, Isabel U.C. Otto, Christina Schürger, Bruno Rogalla von Bieberstein, Kathrin Doppler, Susanne M. Krug, Mohammed K. Hankir, Rosel Blasig, Claudia Sommer, Alexander Brack, Ingolf E. Blasig, Heike L. Rittner
Publikováno v:
Neurobiology of Disease, Vol 185, Iss , Pp 106246- (2023)
Background: The blood-nerve and myelin barrier shield peripheral neurons and their axons. These barriers are sealed by tight junction proteins, which control the passage of potentially noxious molecules including proinflammatory cytokines via paracel
Externí odkaz:
https://doaj.org/article/555600b0ece440f998ec1507add56ceb
Autor:
Martina Schneemann, Lucas Heils, Verena Moos, Franziska Weiß, Susanne M. Krug, January Weiner, Dieter Beule, Ralf Gerhard, Jörg-Dieter Schulzke, Roland Bücker
Publikováno v:
Toxins, Vol 15, Iss 11, p 643 (2023)
Background: Clostridioides difficile toxins TcdA and TcdB are responsible for diarrhea and colitis. Lack of functional studies in organoid models of the gut prompted us to elucidate the toxin’s effects on epithelial barrier function and the molecul
Externí odkaz:
https://doaj.org/article/7f3885d1b10448c8ab6e17773d112dc2
Autor:
Susanne M. Krug, Carolin Grünhagen, Kristina Allers, Christian Bojarski, Joachim Seybold, Thomas Schneider, Jörg-Dieter Schulzke, Hans-Jörg Epple
Publikováno v:
Cells, Vol 12, Iss 14, p 1887 (2023)
Based on indirect evidence, increased mucosal translocation of gut-derived microbial macromolecules has been proposed as an important pathomechanism in HIV infection. Here, we quantified macromolecule translocation across intestinal mucosa from treat
Externí odkaz:
https://doaj.org/article/c5c79210e68047a584b8e58bbdbdbc28
Autor:
Alexis J. Haas, Ceniz Zihni, Susanne M. Krug, Riccardo Maraspini, Tetsuhisa Otani, Mikio Furuse, Alf Honigmann, Maria S. Balda, Karl Matter
Publikováno v:
Cells; Volume 11; Issue 23; Pages: 3775
Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell–cell junction assembly. Here, we combined methods to modulate ECM stiffness and to measure mechanical forces on adhesion complexes to investigate how t
Autor:
Alexis J. Haas, Ceniz Zihni, Susanne M. Krug, Riccardo Maraspini, Tetsuhisa Otani, Mikio Furuse, Alf Honigmann, Maria Balda, Karl Matter
Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell-cell junction assembly. Here, we combined methods to modulate ECM stiffness and to measure mechanical forces on adhesion complexes to investigate how tig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ab9ec28b2eeb14171ee98de5ad07665
https://doi.org/10.1101/2022.07.17.500023
https://doi.org/10.1101/2022.07.17.500023
Autor:
Ann Kristin Reinhold, Susanne M. Krug, Ellaine Salvador, Reine S. Sauer, Franziska Karl‐Schöller, Marzia Malcangio, Claudia Sommer, Heike L. Rittner
Publikováno v:
Annals of the New York Academy of SciencesREFERENCES. 1515(1)
Both nerve injury and complex regional pain syndrome (CRPS) can result in chronic pain. In traumatic neuropathy, the blood nerve barrier (BNB) shielding the nerve is impaired—partly due to dysregulated microRNAs (miRNAs). Upregulation of microRNA-2
Autor:
Franziska Weiß, David Holthaus, Martin Kraft, Christian Klotz, Martina Schneemann, Jörg D. Schulzke, Susanne M. Krug
Publikováno v:
Annals of the New York Academy of SciencesREFERENCES. 1515(1)
Usually, duodenal barriers are investigated using intestinal cell lines like Caco-2, which in contrast to native tissue are limited in cell-type representation. Organoids can consist of all intestinal cell types and are supposed to better reflect the
Autor:
Caroline Hempel, Rita Rosenthal, Anja Fromm, Susanne M. Krug, Michael Fromm, Dorothee Günzel, Jörg Piontek
Publikováno v:
Annals of the New York Academy of SciencesREFERENCES. 1515(1)
Although functional and structural models for paracellular channels formed by claudins have been reported, mechanisms regulating charge and size selectivity of these channels are unknown in detail. Here, claudin-15 and claudin-10b cation channels sho