Adaptive immune changes associate with clinical progression of Alzheimer’s disease

Autor: Lynn van Olst, Alwin Kamermans, Sem Halters, Susanne M. A. van der Pol, Ernesto Rodriguez, Inge M. W. Verberk, Sanne G. S. Verberk, Danielle W. R. Wessels, Carla Rodriguez-Mogeda, Jan Verhoeff, Dorine Wouters, Jan Van den Bossche, Juan J. Garcia-Vallejo, Afina W. Lemstra, Maarten E. Witte, Wiesje M. van der Flier, Charlotte E. Teunissen, Helga E. de Vries

Publikováno v: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)

Abstract Background Alzheimer’s disease (AD) is the most frequent cause of dementia. Recent evidence suggests the involvement of peripheral immune cells in the disease, but the underlying mechanisms remain unclear. Methods We comprehensively mapped

Externí odkaz: https://doaj.org/article/bbeaac8f21914591a0b29202e34aed6d

P-glycoprotein acts as an immunomodulator during neuroinflammation.

Autor: Gijs Kooij, Ronald Backer, Jasper J Koning, Arie Reijerkerk, Jack van Horssen, Susanne M A van der Pol, Joost Drexhage, Alfred Schinkel, Christine D Dijkstra, Joke M M den Haan, Teunis B H Geijtenbeek, Helga E de Vries

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8212 (2009)

BACKGROUND:Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system in which autoreactive myelin-specific T cells cause extensive tissue damage, resulting in neurological deficits. In the disease process, T cells are

Externí odkaz: https://doaj.org/article/66dcdddd3e134339a9a7a05ab1d5b17c

Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells

Autor: Sabela Rodríguez-Lorenzo, Susanne M. A. van der Pol, Helga E. de Vries, Sandra Amor, Maarten E. Witte, Jack van Horssen, Julia Konings, Gijs Kooij, Alwin Kamermans

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Acta Neuropathologica Communications
Rodríguez-Lorenzo, S, Konings, J, Van Der Pol, S, Kamermans, A, Amor, S, Van Horssen, J, Witte, M, Kooij, G & De Vries, H E 2020, ' Inflammation of the choroid plexus in progressive multiple sclerosis : Accumulation of granulocytes and T cells ', Acta neuropathologica communications, vol. 8, no. 1, 9 . https://doi.org/10.1186/s40478-020-0885-1
Acta neuropathologica communications, 8(1):9. BioMed Central

The choroid plexus (CP) is strategically located between the peripheral blood and the cerebrospinal fluid, and is involved in the regulation of central nervous system (CNS) homeostasis. In multiple sclerosis (MS), demyelination and inflammation occur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa17b7122b5c306945ca18a22660462
https://doaj.org/article/8c7ddcfe2bec45a086daa724750ab49d

Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

Autor: Gijs Kooij, Ernesto Rodríguez, Alwin Kamermans, Lynn van Olst, Carla Rodriguez-Mogeda, Susanne M. A. van der Pol, Sabela Rodríguez-Lorenzo, Helga E. de Vries

Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell infiltration resulting in lesions that preferentially affect periventricular areas of the brain. Despite research efforts to define the role of various immune cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d114b0f0f8878467adb0a408dc948fd0
https://doi.org/10.1101/2021.09.17.460741

Pro-resolving lipid mediator lipoxin A 4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

Autor: Alessandro Leuti, Paul C. Norris, Gaby Enzmann, Gijs Kooij, Silvia Tietz, Marijn Schouten, Valerio Chiurchiù, Britta Engelhardt, Susanne M. A. van der Pol, Charles N. Serhan, Neda Haghayegh Jahromi, Alwin Kamermans, Claudio Derada Troletti, Helga E. de Vries

Publikováno v: Cell reports (2021). doi:10.1016/j.celrep.2021.109201
info:cnr-pdr/source/autori:Claudio Derada Troletti 1, Gaby Enzmann 2, Valerio Chiurchiù 3, Alwin Kamermans 4, Silvia Martina Tietz 2, Paul C Norris 5, Neda Haghayegh Jahromi 2, Alessandro Leuti 6, Susanne M A van der Pol 4, Marijn Schouten 4, Charles N Serhan 5, Helga E de Vries 4, Britta Engelhardt 2, Gijs Kooij 7/titolo:Pro-resolving lipid mediator lipoxin A 4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome/doi:10.1016%2Fj.celrep.2021.109201/rivista:Cell reports/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Derada Troletti, C, Enzmann, G, Chiurchiù, V, Kamermans, A, Tietz, S M, Norris, P C, Jahromi, N H, Leuti, A, van der Pol, S M A, Schouten, M, Serhan, C N, de Vries, H E, Engelhardt, B & Kooij, G 2021, ' Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome ', Cell Reports, vol. 35, no. 9, 109201 . https://doi.org/10.1016/j.celrep.2021.109201
Derada Troletti, Claudio; Enzmann, Gaby; Chiurchiù, Valerio; Kamermans, Alwin; Tietz, Silvia Martina; Norris, Paul C; Haghayegh Jahromi, Neda; Leuti, Alessandro; van der Pol, Susanne M A; Schouten, Marijn; Serhan, Charles N; de Vries, Helga E; Engelhardt, Britta; Kooij, Gijs (2021). Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome. Cell reports, 35(9), p. 109201. Cell Press 10.1016/j.celrep.2021.109201
Cell Reports, 35(9):109201. Cell Press

The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0958f3128127b1bba5858f5cc0149cc0