Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Susanne M, Krug"'
Autor:
Jeremy Tsung-Chieh Chen, Xiawei Hu, Isabel U.C. Otto, Christina Schürger, Bruno Rogalla von Bieberstein, Kathrin Doppler, Susanne M. Krug, Mohammed K. Hankir, Rosel Blasig, Claudia Sommer, Alexander Brack, Ingolf E. Blasig, Heike L. Rittner
Publikováno v:
Neurobiology of Disease, Vol 185, Iss , Pp 106246- (2023)
Background: The blood-nerve and myelin barrier shield peripheral neurons and their axons. These barriers are sealed by tight junction proteins, which control the passage of potentially noxious molecules including proinflammatory cytokines via paracel
Externí odkaz:
https://doaj.org/article/555600b0ece440f998ec1507add56ceb
Autor:
Martina Schneemann, Lucas Heils, Verena Moos, Franziska Weiß, Susanne M. Krug, January Weiner, Dieter Beule, Ralf Gerhard, Jörg-Dieter Schulzke, Roland Bücker
Publikováno v:
Toxins, Vol 15, Iss 11, p 643 (2023)
Background: Clostridioides difficile toxins TcdA and TcdB are responsible for diarrhea and colitis. Lack of functional studies in organoid models of the gut prompted us to elucidate the toxin’s effects on epithelial barrier function and the molecul
Externí odkaz:
https://doaj.org/article/7f3885d1b10448c8ab6e17773d112dc2
Autor:
Susanne M. Krug, Carolin Grünhagen, Kristina Allers, Christian Bojarski, Joachim Seybold, Thomas Schneider, Jörg-Dieter Schulzke, Hans-Jörg Epple
Publikováno v:
Cells, Vol 12, Iss 14, p 1887 (2023)
Based on indirect evidence, increased mucosal translocation of gut-derived microbial macromolecules has been proposed as an important pathomechanism in HIV infection. Here, we quantified macromolecule translocation across intestinal mucosa from treat
Externí odkaz:
https://doaj.org/article/c5c79210e68047a584b8e58bbdbdbc28
Autor:
Jia-Chen E. Hu, Franziska Weiß, Christian Bojarski, Federica Branchi, Jörg-Dieter Schulzke, Michael Fromm, Susanne M. Krug
Publikováno v:
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Ulcerative colitis (UC) has a relapsing and remitting pattern, wherein the underlying mechanisms of the relapse might involve an enhanced uptake of luminal antigens which stimulate the immune response. The tricellular tight juncti
Externí odkaz:
https://doaj.org/article/34df0e68687349aea2f0d276e6d12885
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/ad780cdad8d240c1aec1644ca45f6724
Autor:
Alexis J. Haas, Ceniz Zihni, Susanne M. Krug, Riccardo Maraspini, Tetsuhisa Otani, Mikio Furuse, Alf Honigmann, Maria S. Balda, Karl Matter
Publikováno v:
Cells, Vol 11, Iss 23, p 3775 (2022)
Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell–cell junction assembly. Here, we combined methods to modulate ECM stiffness and to measure mechanical forces on adhesion complexes to investigate how t
Externí odkaz:
https://doaj.org/article/e7b3e7e929824f498510bfc8c4f6c124
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Inflammatory bowel disease describes chronic inflammatory disorders. The incidence of the disease is rising. A major step in disease development is the breakdown of the epithelial cell barrier. Numerous blood vessels are directly located underneath t
Externí odkaz:
https://doaj.org/article/1ce5b47548c44dc58b47fd8c924cf81a
Autor:
Deborah Delbue, Lydia Lebenheim, Danielle Cardoso-Silva, Violaine Dony, Susanne M. Krug, Jan F. Richter, Subhakankha Manna, Melba Muñoz, Kerstin Wolk, Claudia Heldt, Markus M. Heimesaat, Robert Sabat, Britta Siegmund, Michael Schumann
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Background: Interleukin-22 (IL-22) impacts the integrity of intestinal epithelia and has been associated with the development of colitis-associated cancer and inflammatory bowel diseases (IBD). Previous data suggest that IL-22 protects the mucosal ba
Externí odkaz:
https://doaj.org/article/113c05147356492e9a76707d9906f783
Autor:
Franziska Weiß, Carolina Czichos, Lukas Knobe, Lena Voges, Christian Bojarski, Geert Michel, Michael Fromm, Susanne M. Krug
Publikováno v:
Cells, Vol 11, Iss 9, p 1541 (2022)
In inflammatory bowel disease (IBD), the impaired intestinal barrier is mainly characterized by changes in tight junction protein expression. The functional role of the tight junction-associated MARVEL protein MARVELD3 (MD3) in IBD is yet unknown. (i
Externí odkaz:
https://doaj.org/article/03b91fb12b674c1abe50447e18dc4c27
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 1, Pp 33-46 (2017)
The intestinal epithelium can be easily disrupted during gut inflammation as seen in inflammatory bowel disease (IBD), such as ulcerative colitis or Crohnâs disease. For a long time, research into the pathophysiology of IBD has been focused on immun
Externí odkaz:
https://doaj.org/article/e0e529909ce2435eb385f15495d6dbea